ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling

Introduction to NF-κB: players, pathways, perspectives

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A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

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Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

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Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

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Nuclear factor-?B: its role in health and disease

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A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

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Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

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Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

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Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway

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Transcriptional regulation via the NF-κB signaling module

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Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation

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Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions

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An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

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Tie receptors: new modulators of angiogenic and lymphangiogenic responses

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Angiopoietin-1 Reduces VEGF-Stimulated Leukocyte Adhesion to Endothelial Cells by Reducing ICAM-1, VCAM-1, and E-Selectin Expression

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A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis

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The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

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Optineurin Negatively Regulates TNFα- Induced NF-κB Activation by Competing with NEMO for Ubiquitinated RIP

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Nuclear Factor κB–dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a Activity

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ABIN-1 Binds to NEMO/IKKγ and Co-operates with A20 in Inhibiting NF-κB

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Identification of Direct Genomic Targets Downstream of the Nuclear Factor-κB Transcription Factor Mediating Tumor Necrosis Factor Signaling

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Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins

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Hepatic Tumor Necrosis Factor Signaling and Nuclear Factor-κB: Effects on Liver Homeostasis and Beyond

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NF-κB1/p105 Regulates Lipopolysaccharide-Stimulated MAP Kinase Signaling by Governing the Stability and Function of the Tpl2 Kinase

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Live and Let Die

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Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes

Wullaert, A., Heyninck, K., & Beyaert, R. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.003 · Cited by 200 · see citing works

Identification of NF-κB-regulated genes induced by TNFα utilizing expression profiling and RNA interference

Zhou, A., Scoggin, S. O., Gaynor, R. B., & Williams, N. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206262 · Cited by 177 · see citing works

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

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The Antiinflammatory Endothelial Tyrosine Kinase Tie2 Interacts With a Novel Nuclear Factor-κB Inhibitor ABIN-2

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P-selectin primes leukocyte integrin activation during inflammation

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Inflammatory cardiac valvulitis in TAX1BP1‐deficient mice through selective NF‐κB activation

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The IκB Kinase Complex and NF-κB Actas Master Regulators of Lipopolysaccharide-Induced Gene Expressionand Control Subordinate Activation ofAP-1

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Divergent gene regulation and growth effects by NF-κB in epithelial and mesenchymal cells of human skin

Hinata, K., Gervin, A. M., Zhang, J. Y., & Khavari, P. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206198 · Cited by 130 · see citing works

Transcriptional profiling of IKK2/NF-κB— and p38 MAP kinasedependent gene expression in TNF-α—stimulated primary human endothelial cells

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NF-κB1 p105 Negatively Regulates TPL-2 MEK Kinase Activity

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Structure–function analysis of the A20‐binding inhibitor of NF‐κB activation, ABIN‐1

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Identification of a Novel A20-binding Inhibitor of Nuclear Factor-κB Activation Termed ABIN-2

Huffel, S. V., Delaei, F., Heyninck, K., VALCK, D. D., & Beyaert, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100048200 · Cited by 98 · see citing works

ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability

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Angiopoietin-1 Inhibits Irradiation- and Mannitol-Induced Apoptosis in Endothelial Cells

Kwak, H. J., Lee, S. J., Lee, Y.-H., Ryu, C. H., Koh, K. N., Choi, H. Y., & Koh, G. Y. (2000) · Circulation · doi:10.1161/01.cir.101.19.2317 · Cited by 89 · see citing works

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

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Regulation of the NF-κB Activation Pathway by Isolated Domains of FIP3/IKKγ, a Component of the IκB-α Kinase Complex

Ye, J., Xie, X., Tarassishin, L., & Horwitz, M. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9882 · Cited by 85 · see citing works

LIND/ABIN-3 Is a Novel Lipopolysaccharide-inducible Inhibitor of NF-κB Activation

Wullaert, A., Verstrepen, L., Huffel, S. V., Adib‐Conquy, M., Cornelis, S., Kreike, M., Haegman, M., Bakkouri, K. E., Sanders, M., Verhelst, K., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607481200 · Cited by 81 · see citing works

ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1

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cDNA Microarray Analysis Reveals a Nuclear Factor-κB-Independent Regulation of Macrophage Function by Adenosine

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Tumor Necrosis Factor α Prevents Tumor Necrosis Factor Receptor—Mediated Mouse Hepatocyte Apoptosis, But Not Fas–Mediated Apoptosis: Role of Nuclear Factor–κB

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Two novel genes FIND and LIND differentially expressed in deactivated and Listeria -infected human macrophages

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A Human Nuclear Shuttling Protein That Interacts with Human Immunodeficiency Virus Type 1 Matrix Is Packaged into Virions

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Putting the Brake on Inflammatory Responses: the Role of Glucocorticoids

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Use of a Combined Ex Vivo/In Vivo Population Approach for Screening of Human Genes Involved in the Human Immunodeficiency Virus Type 1 Life Cycle for Variants Influencing Disease Progression

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Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease

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Identification of a novel mechanism of NF-κB inactivation by progesterone through progesterone receptors in Hec50co poorly differentiated endometrial cancer cells: induction of A20 and ABIN-2

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Adenoviral Gene Transfer of the NF-κB Inhibitory Protein ABIN-1 Decreases Allergic Airway Inflammation in a Murine Asthma Model

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Identification and cloning of a novel cellular protein Naf1, Nef‐associated factor 1, that increases cell surface CD4 expression1

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ABIN-3: a Molecular Basis for Species Divergence in Interleukin-10-Induced Anti-Inflammatory Actions

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Gene expression patterns of epithelial cells modulated by pathogenicity factors ofYersinia enterocolitica

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Identification of Naf1/ABIN‐1 among TNF‐α‐induced expressed genes in human synoviocytes using oligonucleotide microarrays

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Adenoviral gene transfer of ABIN‐1 protects mice from TNF/galactosamine‐induced acute liver failure and lethality†

Wullaert, A., Wielockx, B., Huffel, S. V., Bogaert, V., Geest, B. D., Papeleu, P., Schotte, P., Bakkouri, K. E., Heyninck, K., Libert, C., et al. (2005) · Hepatology · doi:10.1002/hep.20785 · Cited by 49 · see citing works

Molecular tools to reestablish progestin control of endometrial cancer cell proliferation

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A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling

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Expression of the NF‐κB inhibitor ABIN‐3 in response to TNF and toll‐like receptor 4 stimulation is itself regulated by NF‐κB

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The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis

Liu, W.-K., Yen, P., Chien, C.-Y., Fann, M., Su, J.-Y., & Chou, C. (2004) · Biochemical Journal · doi:10.1042/bj20031736 · Cited by 33 · see citing works

Gene Expression Profiling in Conjunction with Physiological Rescues of IKKα-null Cells with Wild Type or Mutant IKKα Reveals Distinct Classes of IKKα/NF-κB-dependent Genes

Massa, P. E., Li, X., Hanidu, A., Siamas, J., Pariali, M., Pareja, J., Savitt, A. G., Catron, K. M., Li, J., & Marcu, K. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414401200 · Cited by 28 · see citing works

ABINs inhibit EGF receptor-mediated NF-κB activation and growth of EGF receptor-overexpressing tumour cells

Huang, L., Verstrepen, L., Heyninck, K., Wullaert, A., Revets, H., BAETSELIER, P. D., & Beyaert, R. (2008) · Oncogene · doi:10.1038/onc.2008.208 · Cited by 27 · see citing works

Stability of A+U-Rich Element Binding Factor 1 (AUF1)-Binding Messenger Ribonucleic Acid Correlates with the Subcellular Relocalization of AUF1 in the Rat Uterus upon Estrogen Treatment

Arao, Y., Kikuchi, A., Kishida, M., Yonekura, M., Inoue, A., Yasuda, S., Wada, S., Ikeda, K., & Kayama, F. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0103 · Cited by 21 · see citing works

High Frequency of Alternative Splicing of Human Genes Participating in the HIV-1 Life Cycle

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Multiple splicing variants of Naf1/ABIN-1 transcripts and their alterations in hematopoietic tumors

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An LKB1-Interacting Protein Negatively Regulates TNFα-Induced NF-κB Activation

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The A20‐binding protein ABIN‐2 exerts unexpected function in mediating transcriptional coactivation

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Overexpression of ABIN-2, a negative regulator of NF-κB, delays liver regeneration in the ABIN-2 transgenic mice

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Naf1α is phosphorylated in mitotic phase and required to protect cells against apoptosis

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Making more of academic assets

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New insights into the genetic etiology of Alzheimer’s disease and related dementias

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Crosstalk in NF-κB Signaling Pathways

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Neuroinflammation in Alzheimer disease

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Deubiquitinases in cancer: new functions and therapeutic options

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NF-κB in inflammation and renal diseases

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Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

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Regulation of nuclear factor-κB in autoimmunity

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