The DOI matches its Crossref record; 376 of the 379 references it cites were found in a registry or an index.
Motivations and Methods for Analyzing Pulsatile Hormone Secretion
Open accessAbstract
Endocrine glands communicate with remote target cells via a mixture of continuous and intermittent signal exchange. Continuous signaling allows slowly varying control, whereas intermittency permits large rapid adjustments. The control systems that mediate such homeostatic corrections operate in a species-, gender-, age-, and context-selective fashion. Significant progress has been made in understanding mechanisms of adaptive interglandular signaling in vivo. Principal goals are to understand the physiological origins, significance, and mechanisms of pulsatile hormone secretion. Key analytical issues are: 1) to quantify the number, size, shape, and uniformity of pulses, nonpulsatile (basal) secretion, and elimination kinetics; 2) to evaluate regulation of the axis as a whole; and 3) to reconstruct dose-response interactions without disrupting hormone connections. This review will focus on the motivations driving and the methodologies used for such analyses.
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“To our knowledge, pulsatile ACTH secretion after caloric ingestion has never been quantified adequately by current standards (16).”
From Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men. (2011) · cites this paper as [16]
Citations
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Cited by
Sorted by citations
Diabetes: Models, Signals, and Control
Cobelli, C., Dalla Man, C., Sparacino, G., Magni, L., De Nicolao, G., & Kovatchev, B. P. (2009) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2009.2036073 · Cited by 511
“It has been established that the ability of glucose to entrain ultradian insulin secretion patterns is disturbed in diabetic and prediabetic individuals [157]–[159], but the exact role of oscillations in the glucose regulation systems is still under investigation [160].”
Dynamic regulation of transcriptional states by chromatin and transcription factors
Voss, T. C., & Hager, G. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3623 · Cited by 504
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Ranke, M. B., & Wit, J. M. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.22 · Cited by 362
Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes
Satin, L. S., Butler, P. C., Ha, J., & Sherman, A. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.01.003 · Cited by 243
Beckman, B. R. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.08.009 · Cited by 233
Metadata
- Authors
- Veldhuis, J. D., Keenan, D. M., & Pincus, S. M.
- Affiliations
- Mayo Clinic (US)
- University of Virginia (US)
- Independent Statistician (S.M.P.), Guilford, Connecticut 06437
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2008-12-01
- Volume
- 29
- Issue
- 7
- Pages
- 823-864
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- PMC
- PMC2647703
- OpenAlex
- W2098329444
- Cited by
- 223
- References
- 379
- Citations by year
- 2026: 11 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 12 · 2018: 15 · 2017: 16 · 2016: 14 · 2015: 14 · 2014: 16 · 2013: 14 · 2012: 16
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R21AG023777, AG-23133, R21 AG 29215, AG-29362, R01AG029362, R01AG023133, R01 NIA AG019695, AG23777, R01AG019695, R21AG029215, R37AG019695)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK73148, R01DK073148)
- National Center for Research Resources (M01-RR00 585, M01RR000585)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- pulsatile hormone secretion, pulse analysis, basal secretion, elimination kinetics, dose-response interaction, homeostatic regulation
- MeSH terms
- Animals, Endocrine Glands, Hormones, Humans, Pulsatile Flow, Secretory Rate
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