Allosteric Modulators of Steroid Hormone Receptors: Structural Dynamics and Gene Regulation

Kumar, Raj, McEwan, Iain J.·2012·Endocrine Reviews

Cites (253)

Items 201–253 of 253

  1. A Conformational Switch in the Ligand-binding Domain Regulates the Dependence of the Glucocorticoid Receptor on Hsp90
    Derek Ricketson, Ute Hostick, L. Fang, Keith R. Yamamoto, Beatrice D. Darimont · 2007 · Journal of Molecular Biology
  2. Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure
    Katharina Fischer, Sharon M. Kelly, Kate Watt, Nicholas C. Price, Iain J. McEwan · 2010 · Molecular Endocrinology
  3. Role of Hydrophobic Amino Acid Clusters in the Transactivation Activity of the Human Glucocorticoid Receptor
    Tova Almlöf, Jan-Ακε Gustafsson, Anthony P. H. Wright · 1997 · Molecular and Cellular Biology
  4. A New Small Molecule Inhibitor of Estrogen Receptor α Binding to Estrogen Response Elements Blocks Estrogen-dependent Growth of Cancer Cells
    Chengjian Mao, Nicole M. Patterson, Milu T. Cherian, Irene O. Aninye, Chen Zhang, Jamie Bonéy Montoya, Jingwei Cheng, Karson S. Putt, Paul J. Hergenrother, Elizabeth M. Wilson et al. · 2008 · Journal of Biological Chemistry
  5. Structural and functional relationships of the steroid hormone receptors’ N-terminal transactivation domain
    Raj Kumar, Gerald Litwack · 2009 · Steroids
  6. Structural and Functional Characterization of the Interdomain Interaction in the Mineralocorticoid Receptor
    Jyotsna B. Pippal, Yizhou Yao, Fraser M. Rogerson, Peter J. Fuller · 2009 · Molecular Endocrinology
  7. Tissue-Specific Pathways for Estrogen Regulation of Ovarian Cancer Growth and Metastasis
    Monique A. Spillman, Nicole G. Manning, Wendy W. Dye · 2010 · Cancer Research
  8. Ligand-Controlled Interaction of Histone Acetyltransferase Binding to ORC-1 (HBO1) with the N-Terminal Transactivating Domain of Progesterone Receptor Induces Steroid Receptor Coactivator 1-Dependent Coactivation of Transcription
    Maria Georgiakaki, Nathalie Chabbert‐Buffet, Boris Dasen, Geri Méduri, Sandra Wenk, Leila Rajhi, Larbi Amazit, Anne Chauchereau, Curt W. Burger, Leen J. Blok et al. · 2006 · Molecular Endocrinology
  9. Intra-domain communication between the N-terminal and DNA-binding domains of the androgen receptor: modulation of androgen response element DNA binding
    Jacqueline Brodie, Iain J. McEwan · 2005 · Journal of Molecular Endocrinology
  10. Unfoldomics of Human Genetic Diseases: Illustrative Examples of Ordered and Intrinsically Disordered Members of the Human Diseasome
    Uros Midic, Christopher J. Oldfield, A. Keith Dunker, Zoran Obradovic A, Vladimir Nikolaevich Uversky · 2009 · Protein and Peptide Letters
  11. Overview of the structural basis for transcription regulation by nuclear hormone receptors
    Raj Kumar, Betty H. Johnson, E. Brad Thompson · 2004 · Essays in Biochemistry
  12. How Transcriptional Activators Bind Target Proteins
    Stefan Hermann, Kurt D. Berndt, Anthony P. H. Wright · 2001 · Journal of Biological Chemistry
  13. The Androgen Receptor Interacts with Multiple Regions of the Large Subunit of General Transcription Factor TFIIF
    James Reid, Ian Murray, Kate Watt, Russell Betney, Iain J. McEwan · 2002 · Journal of Biological Chemistry
  14. Global Characterization of Transcriptional Impact of the SRC-3 Coregulator
    Rainer B. Lanz, Yaroslava A. Bulynko, Anna Malovannaya, Paul Labhart, Liguo Wang, Wei Li, Jun Qin, Mary‐Ellen Harper, Bert W. O’Malley · 2010 · Molecular Endocrinology
  15. Intrinsic Disorder in Nuclear Hormone Receptors
    Matthew D. Krasowski, Erica J. Reschly, Sean Ekins · 2008 · Journal of Proteome Research
  16. Transcriptional activation by nuclear receptors
    Mari Luz Acevedo, W. Lee Kraus · 2004 · Essays in Biochemistry
  17. Dual Function of an Amino-terminal Amphipatic Helix in Androgen Receptor-mediated Transactivation through Specific and Nonspecific Response Elements
    Leen Callewaert, Guy Verrijdt, Valerie Christiaens, Annemie Haelens, Frank Claessens · 2003 · Journal of Biological Chemistry
  18. Minireview: Role of Kinases and Chromatin Remodeling in Progesterone Signaling to Chromatin
    Guillermo Pablo Vicent, Ana Silvina Nacht, Roser Zaurín, Cecilia Ballaré, Jaime Clausell, Miguel Beato · 2010 · Molecular Endocrinology
  19. Posttranslational Modifications and Subcellular Localization Signals: Indicators of Sequence Regions without Inherent 3D Structure?
    Birgit Eisenhaber, Frank Eisenhaber · 2007 · Current Protein and Peptide Science
  20. Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen
    Donald Patrick McDonnell · 2000 · Journal of the Society for Gynecologic Investigation
  21. Identification of Ligand-Selective Peptide Antagonists of the Mineralocorticoid Receptor Using Phage Display
    Jun Yang, Ching‐yi Chang, Rachid Safi, James Morgan, Donald Patrick McDonnell, Peter J. Fuller, Colin D. Clyne, Morag J. Young · 2010 · Molecular Endocrinology
  22. Functional Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: Binding Kinetics for Interactions with TFIIF and SRC-1a
    Derek N. Lavery, Iain J. McEwan · 2008 · Biochemistry
  23. A 629RKLKK633 motif in the hinge region controls the androgen receptor at multiple levels
    Tamzin Tanner, Sarah Denayer, Bart Geverts, Nora Van Tilborgh, Stefanie Kerkhofs, Christine Helsen, Lien Spans, Vanessa Dubois, Adriaan B. Houtsmuller, Frank Claessens et al. · 2010 · Cellular and Molecular Life Sciences
  24. Aldosterone: A cardiovascular risk factor?
    Funder, John W., Reincke, Martin · 2010 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  25. Regulation of the Amino-Terminal Transcription Activation Domain of Progesterone Receptor by a Cofactor-Induced Protein Folding Mechanism
    Suzanne E. Wardell, Stanley C. Kwok, Lori Sherman, Robert S. Hodges, Dean P. Edwards · 2005 · Molecular and Cellular Biology
  26. Structural Studies of Mutant Glucocorticoid Receptor Transactivation Domains Establish a Link between Transactivation Activity in Vivo and α-Helix-Forming Potential in Vitro
    Karin Dahlman‐Wright, Iain J. McEwan · 1996 · Biochemistry
  27. pS2Gene Expression in HepG2 cells: Complex Regulation through Crosstalk between the Estrogen Receptor α, an Estrogen-Responsive Element, and the Activator Protein 1 Response Element
    Tomas Barkhem, Lars‐Arne Haldosén, Jan-Åke Gustafsson, Stefan V. Nilsson · 2002 · Molecular Pharmacology
  28. Reconstitution of the N-terminal Transcription Activation Function of Human Mineralocorticoid Receptor in a Defective Human Glucocorticoid Receptor
    Manjapra V. Govindan, Nalini Warriar · 1998 · Journal of Biological Chemistry
  29. Direct Interdomain Interactions Can Mediate Allosterism in the Thyroid Receptor
    Balananda‐Dhurjati Kumar Putcha, Elias J. Fernandez · 2009 · Journal of Biological Chemistry
  30. Intrinsically unstructured N‐terminal domain of bZIP transcription factor HY5
    Mi‐Kyung Yoon, Jieun Shin, Giltsu Choi, Byong‐Seok Choi · 2006 · Proteins Structure Function and Bioinformatics
  31. Mutations at Positions 547–553 of Rat Glucocorticoid Receptors Reveal That hsp90 Binding Requires the Presence, but Not Defined Composition, of a Seven-amino Acid Sequence at the Amino Terminus of the Ligand Binding Domain
    Sunil C. Kaul, Patrick J.M. Murphy, Jun Chen, Lloyd Brown, William B. Pratt, S. Stoney Simons · 2002 · Journal of Biological Chemistry
  32. The molecular basis of eucaryotic transcription
    R. Kornberg · 2007 · Cell Death and Differentiation
  33. Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements
    Lonnele J. Ball, Nitzan Levy, Xiaoyue Zhao, Chandi A Griffin, Mary Ann Tagliaferri, Isaac V. Cohen, William A. Ricke, Terence Paul Speed, Gary L. Firestone, Dale C. Leitman · 2008 · Molecular and Cellular Endocrinology
  34. A Large Intrinsically Disordered Region in SKIP and Its Disorder-Order Transition Induced by PPIL1 Binding Revealed by NMR
    Xinsheng Wang, Shaojie Zhang, Jiahai Zhang · 2009 · Journal of Biological Chemistry
  35. GRIP1 mediates the interaction between the amino- and carboxyl-termini of the androgen receptor
    Howard C. Shen, Grant Buchanan, Lisa M. Butler · 2005 · Biological Chemistry
  36. TBP Binding-Induced Folding of the Glucocorticoid Receptor AF1 Domain Facilitates Its Interaction with Steroid Receptor Coactivator-1
    Shagufta H. Khan, Jun Ling, Praveen Kumar · 2011 · PLoS ONE
  37. Androgen receptor acetylation sites differentially regulate gene control
    Hortensia Faus, Bernard Haendler · 2007 · Journal of Cellular Biochemistry
  38. Development of peptide antagonists that target estrogen receptor-cofactor interactions.
    D. McDonnell, Ching-Yi Chang, J. Norris · 2000 · Journal of Steroid Biochemistry and Molecular Biology
  39. Role of conserved hydrophobic amino acids in androgen receptor AF-1 function
    Russell Betney, IJ McEwan · 2003 · Journal of Molecular Endocrinology
  40. Intramolecular interactions between the AF3 domain and the C-terminus of the human progesterone receptor are mediated through two LXXLL motifs
    Xuesen Dong, Challis, Stephen James Lye · 2004 · Journal of Molecular Endocrinology
  41. A Progesterone Receptor Co-activator (JDP2) Mediates Activity through Interaction with Residues in the Carboxyl-terminal Extension of the DNA Binding Domain
    Krista K. Hill, Sarah C. Roemer, David N. M. Jones, Mair E. A. Churchill, Dean P. Edwards · 2009 · Journal of Biological Chemistry
  42. Effects of different osmolytes on the induced folding of the N-terminal activation domain (AF1) of the glucocorticoid receptor
    Raj Kumar, Justin M. Serrette, S.H. Khan, A.L. Miller, E. Brad Thompson · 2007 · Archives of Biochemistry and Biophysics
  43. Isoform‐specific variation in the intrinsic disorder of the ecdysteroid receptor N‐terminal domain
    Małgorzata Nocula‐Ługowska, Grzegorz Rymarczyk, Marek Lisowski, Andrzej Ożyhar · 2008 · Proteins Structure Function and Bioinformatics
  44. Nuclear Receptor Superfamily
    Julia A. Lawrence, Kapil Dhingra · 2004 · Humana Press eBooks
  45. Naturally Occurring Osmolyte, Trehalose Induces Functional Conformation in an Intrinsically Disordered Activation Domain of Glucocorticoid Receptor
    Shagufta H. Khan, John A. Arnott, Raj Kumar · 2011 · PLoS ONE
  46. Partial Agonist Activity of the Progesterone Receptor Antagonist RU486 Mediated by an Amino-Terminal Domain Coactivator and Phosphorylation of Serine400
    Suzanne E. Wardell, Ramesh Narayanan, Nancy L. Weigel, Dean P. Edwards · 2009 · Molecular Endocrinology
  47. Selective Estrogen Receptor Modulators (SERMs): A First Step in the Development of Perfect Hormone Replacement Therapy Regimen
    Donald Patrick McDonnell · 2000 · Journal of the Society for Gynecologic Investigation
  48. Intrinsic disorder of Drosophila melanogaster hormone receptor 38 N‐terminal domain
    Agnieszka Dziedzic‐Letka, Grzegorz Rymarczyk, Tomasz M. Kapłon, Andrzej Górecki, Agnieszka Szamborska‐Gbur, Magdalena Wojtas, Piotr Dobryszycki, Andrzej Ożyhar · 2010 · Proteins Structure Function and Bioinformatics
  49. Influence of flanking sequences on signaling between the activation function AF1 and DNA-binding domain of the glucocorticoid receptor
    Raj Kumar, E. Brad Thompson · 2010 · Archives of Biochemistry and Biophysics
  50. Chimeric receptors used to probe the DNA-binding domain of the estrogen and glucocorticoid receptors.
    S. Green, Pierre Chambon · 1989 · PubMed
  51. Protein folding and the order/disorder paradox
    Prakash Kulkarni, Krithika Rajagopalan, David B. Yeater, Robert H. Getzenberg · 2011 · Journal of Cellular Biochemistry
  52. Nuclear Hormone Receptor Architecture - Form and Dynamics: The 2009 FASEB Summer Conference on Dynamic Structure of the Nuclear Hormone Receptors
    Iain J. McEwan, Ann M. Nardulli · 2009 · Nuclear Receptor Signaling
  53. Osmolyte-Induced Folding of an Intrinsically Disordered Activation Function Subdomain of Glucocorticoid Receptor
    Raj Kumar · 2008 · Journal of Receptors and Signal Transduction