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The DOI matches its Crossref record; 311 of the 311 references it cites were found in a registry or an index.

Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures

Open access
Potter, Gregory D. M., Skene, Debra J., Arendt, Josephine, Cade, Janet E., Grant, Peter J., Hardie, Laura J.·2016·Endocrine Reviews

Abstract

Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large proportion of the world's population is at increased risk of environmentally driven circadian rhythm and sleep disruption, and a minority of individuals are also genetically predisposed to circadian misalignment and sleep disorders. The consequences of disruption to the circadian system and sleep are profound and include myriad metabolic ramifications, some of which may be compounded by adverse effects on dietary choices. If not addressed, the deleterious effects of such disruption will continue to cause widespread health problems; therefore, implementation of the numerous behavioral and pharmaceutical interventions that can help restore circadian system alignment and enhance sleep will be important.

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Metadata

Authors
Potter, G. D. M., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J.
Venue
Endocrine Reviews
Published
2016-10-20
Volume
37
Issue
6
Pages
584-608
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
OpenAlex
W2536709198
Cited by
709
References
311
FWCI
14.16
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures. https://app.cochat.ai/papers/10.1210/er.2016-1083
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Potter, G. D. M., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016). Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures. Endocrine Reviews. https://doi.org/10.1210/er.2016-1083

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