The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Marked Decrease in Plasma Antioxidants in Aged Osteoporotic Women: Results of a Cross-Sectional Study
Abstract
Although recent epidemiological studies found a positive correlation between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants in osteoporotic subjects are scanty. The aim of this study was to evaluate whether antioxidant defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress. To answer these questions, plasma vitamins C, E, and A; uric acid; and the enzymatic activities of superoxide dismutase in plasma and erythrocytes and of glutathione peroxidase in plasma were measured in 75 subjects with osteoporosis and 75 controls. Dietary and endogenous antioxidants were consistently lower in osteoporotic than in control subjects. On the other hand, plasma levels of malondialdehyde, a byproduct of lipid peroxidation, did not differ between groups. Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation.
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Cites
Peterkofsky, B. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1135s · Cited by 383
Smoking, Antioxidant Vitamins, and the Risk of Hip Fracture
Melhus, H., Michaëlsson, K., Holmberg, L., Wolk, A., & Ljunghall, S. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.1.129 · Cited by 251
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Weitzmann, M. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28550 · Cited by 990
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OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism
Walsh, M. C., Kim, N., Kadono, Y., Rho, J., Lee, S. Y., Lorenzo, J., & Choi, Y. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090646 · Cited by 724
Reactive oxygen species mediate RANK signaling in osteoclasts
Ha, H., Bok Kwak, H., Woong Lee, S., Mi Jin, H., Kim, H.-M., Kim, H.-H., & Hee Lee, Z. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.07.035 · Cited by 347
Valdes, A. M., Richards, J. B., Gardner, J. P., Swaminathan, R., Kimura, M., Xiaobin, L., Aviv, A., & Spector, T. D. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0357-5 · Cited by 164
Role of T cells in ovariectomy induced bone loss—revisited
Pacifici, R. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1500 · Cited by 142
Self-citationEstrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss
Khosla, S., & Pacifici, R. (2013) · Osteoporosis · doi:10.1016/b978-0-12-415853-5.00046-7 · Cited by 31
Papillary thyroid carcinoma is a risk factor for severe osteoporosis
Notsu, M., Yamauchi, M., Morita, M., Nawata, K., & Sugimoto, T. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-019-01053-5 · Cited by 10
Metadata
- Authors
- Maggio, D., Barabani, M., Pierandrei, M., Polidori, M. C., Catani, M., Mecocci, P., Senin, U., Pacifici, R., & Cherubini, A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-04
- Volume
- 88
- Issue
- 4
- Pages
- 1523-1527
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2053516334
- Cited by
- 531
- References
- 2
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- closed
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