Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies
Open accessAbstract
Human mesenchymal stem cells (hMSC) represent a promising cell-based therapy for a number of degenerative conditions. Understanding the effect of aging on hMSCs is crucial for autologous therapy development in older subject whom degenerative diseases typically afflict. Previous investigations into the effects of aging on hMSC have proved contradictory due to the relative narrow age ranges of subjects assessed and the exclusive reliance of in vitro assays. This study seeks to address this controversy by using a wider range of donor ages and by measuring indices of cellular aging as well as hMSC numbers ex vivo and proliferation rates. CFU-f analysis and flow cytometry analysis using a CD45(low)/D7fib(+ve)/LNGF(+ve) gating strategy were employed. In addition a variety of markers of cellular aging, oxidative damage and senescence measured. A reduction in CFU-f and CD45(low)/D7fib(+ve)/LNGF(+ve) cell numbers were noted in adulthood relative to childhood. Indices of aging including oxidative damage, ROS levels and p21 and p53 all increased suggesting a loss of MSC fitness with age. These data suggest that hMSC numbers obtained by marrow aspiration decline with age. Furthermore, there is an age-related decline in overall BM MSC "fitness" which might lead to problems when using autologous aged MSC for cell-based therapies.
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Aged human mesenchymal stem cells have elevated ROS.
“studies of aged human mesenchymal stem cells have found elevated ROS9”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [9]
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- Authors
- Stolzing, A., Jones, E., McGonagle, D., & Scutt, A.
- Affiliations
- University of Sheffield (GB)
- University of Leeds (GB)
- Corresponding author
- Stolzing, A.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 129
- Issue
- 3
- Pages
- 163-173
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2089878334
- Semantic Scholar
- d41fe0496922c16fa7eb22af90fbd0d64435e9c6
- Cited by
- 1,195
- References
- 57
- Citations by year
- 2026: 29 · 2025: 33 · 2024: 54 · 2023: 50 · 2022: 65 · 2021: 89 · 2020: 90 · 2019: 92 · 2018: 69 · 2017: 71 · 2016: 86 · 2015: 88 · 2014: 92 · 2013: 79 · 2012: 72
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.lboro.ac.uk
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Loughborough University Institutional Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- Loughborough University Research Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, bone marrow, aging, cellular senescence, oxidative stress, reactive oxygen species, p21, p53, CFU-F, autologous cell therapy, degenerative diseases, donor age
- MeSH terms
- Adolescent, Adult, Aging, Bone Marrow Cells, Cell Count, Cell Differentiation, Cells, Cultured, Child, Child, Preschool, Humans, Middle Aged, Osteogenesis, Phenotype, Biomarkers, Cellular Senescence, Apoptosis, Reactive Oxygen Species, Mesenchymal Stem Cell Transplantation, Cell Proliferation, Mesenchymal Stem Cells
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