The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Ghrelin and Adipose Tissue Regulatory Peptides: Effect of Gastric Bypass Surgery in Obese Humans
Abstract
Presently surgery is the most effective way to obtain a controlled weight reduction in morbidly obese patients. Roux-en-Y gastric bypass (RYGBP) surgery is effective and used worldwide, but the exact mechanism of action is unknown. The effect of RYGBP on ghrelin, insulin, adiponectin, and leptin levels was investigated in 66 obese subjects; mean weight 127 kg (range, 96-195 kg) and mean body mass index (BMI) 45 kg/m(2) (range, 33-64) before and after surgery. Ghrelin levels were also compared in 10 nonoperated and 10 operated obese, BMI-matched women. RYGBP resulted in 22% and 30% weight loss at 6 and 12 months, respectively. Ghrelin increased by 44% and 62% and adiponectin by 36% and 98%, but insulin declined by 57% and 62% and leptin by 60% and 64%. The changes were all related to the reduction in BMI. In addition, ghrelin and insulin were inversely correlated at all time points as were changes of the peptides at 12 months (F = 4.9, P = 0.031), independent of the change in BMI. No evidence for RYGBP surgery per se having an effect on ghrelin levels, independent of weight loss, was obtained. The profound changes in the regulatory peptides are likely to reflect the new state of energy balance achieved. A close inverse association between ghrelin and insulin was observed, supporting an important role for ghrelin in glucose homeostasis.
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Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.8.3815 · Cited by 1,181
Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro
Kolaczynski, J. W., Nyce, M. R., Considine, R. V., Boden, G., Nolan, J. J., Henry, R., Mudaliar, S. R., Olefsky, J., & Caro, J. F. (1996) · Diabetes · doi:10.2337/diab.45.5.699 · Cited by 700
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
Wierup, N., Svensson, H., Mulder, H., & Sundler, F. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00067-8 · Cited by 457
Cited by
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187
Sun, Y., Wang, P., Zheng, H., & Smith, R. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305930101 · Cited by 745
Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches
Schwartz, A. R., Patil, S. P., Laffan, A. M., Polotsky, V., Schneider, H., & Smith, P. L. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-137mg · Cited by 730
Ghrelin and the short- and long-term regulation of appetite and body weight
Cummings, D. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.022 · Cited by 620
Sleeve Gastrectomy and Gastric Banding: Effects on Plasma Ghrelin Levels
Langer, F. B., Reza Hoda, M. A., Bohdjalian, A., Felberbauer, F. X., Zacherl, J., Wenzl, E., Schindler, K., Luger, A., Ludvik, B., & Prager, G. (2005) · Obesity Surgery · doi:10.1381/0960892054621125 · Cited by 566
Metadata
- Authors
- Holdstock, C., Engström, B. E., Öhrvall, M., Lind, L., Sundbom, M., & Karlsson, F. A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-07-01
- Volume
- 88
- Issue
- 7
- Pages
- 3177-3183
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2106398559
- Cited by
- 316
- References
- 6
- FWCI
- 28.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Holdstock, C., Engström, B. E., Öhrvall, M., Lind, L., Sundbom, M., & Karlsson, F. A. (2003). Ghrelin and Adipose Tissue Regulatory Peptides: Effect of Gastric Bypass Surgery in Obese Humans. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2002-021734
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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