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Cited by 98Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and ResearchMetabolism, Diabetes, and Cancer

Direct Measurements of the Permeability Surface Area for Insulin and Glucose in Human Skeletal Muscle

Gudbjörnsdóttir, Soffia, Sjöstrand, Mikaela, Strindberg, Lena, Wahren, John, Lönnroth, Peter·2003·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-030434
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Abstract

To elucidate mechanisms regulating capillary transport of insulin and glucose, we directly calculated the permeability surface (PS) area product for glucose and insulin in muscle. Intramuscular microdialysis in combination with the forearm model and blood flow measurements was performed in healthy males, studied during an oral glucose tolerance test or during a one-step or two-step euglycemic hyperinsulinemic clamp. PS for glucose increased significantly from 0.29 ± 0.1 to 0.64 ± 0.2 ml/min·100 g after oral glucose tolerance test, and glucose uptake increased from 1.2 ± 0.4 to 2.6 ± 0.6 μmol/min·100 g (P < 0.05). During one-step hyperinsulinemic clamp (plasma insulin, 1.962 pmol/liter), PS for glucose increased from 0.2 ± 0.1 to 2.3 ± 0.9 ml/min·100 g (P < 0.05), and glucose uptake increased from 0.6 ± 0.2 to 5.0 ± 1.4 μmol/min·100 g (P < 0.05). During the two-step clamp (plasma insulin, 1380 ± 408 and 3846 ± 348 pmol/liter), the arterial-interstitial difference and PS for insulin were constant. The PS for glucose tended to increase (P = not significant), whereas skeletal muscle blood flow increased from 4.4 ± 0.7 to 6.2 ± 0.8 ml/min·100 ml (P < 0.05). The present data show that PS for glucose is markedly increased by oral glucose, whereas a further vasodilation exerted by high insulin concentrations may not be physiologically relevant for capillary delivery of either glucose or insulin in resting muscle.

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  • In extracranial segments, transcapillary delivery of insulin from the blood compartment to its adjacent mass compartment is mediated through passive diffusion.

    “In the extracranial segments, the transcapillary delivery of insulin from the blood compartment to its adjacent mass compartment is mediated through passive diffusion [28].”

    From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [28]

    The passage labeled Abstract (page not provided) states that transcapillary delivery of insulin is mediated through passive diffusion, in the context of interstitial fluid around muscle cells. The paper addresses human skeletal muscle, not extracranial segments generally, so it does not establish the claim across that broader setting. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • The estimated permeability coefficients are confirmed by a few available clinical parameters; for example, the permeability coefficient in muscle is 1.7-6.0 ml/min/100 g for glucose and 0.5 ml/min/100 g for insulin.

    “The estimated values are confirmed by a few available clinical parameters. For example, the permeability coefficient in muscle is 1.7-6.0 ml/min/100 g for glucose and 0.5 ml/min/100 g for insulin [28].”

    From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [28]

    The Discussion (page unavailable) estimates insulin’s permeability–surface area product at approximately 0.5 ml/min/100 g, but only for vasodilated muscle under unphysiologically high insulin levels; it says the data cannot establish permeability under more physiological conditions. The study results report glucose values that vary by test condition, including 2.2 ± 0.8 and 4.5 ± 1.6 ml/min/100 g during the two-step clamp, but do not state the claimed 1.7–6.0 range. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • The transcapillary delivery of glucose is under the influence of blood insulin.

    “However, the transcapillary delivery of glucose is under the influence of blood insulin [28].”

    From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [28]

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Authors
Gudbjörnsdóttir, S., Sjöstrand, M., Strindberg, L., Wahren, J., & Lönnroth, P.
Affiliations
  • Lundberg Laboratory for Diabetes Research (S.G., M.S., L.S., P.L.), Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden
  • Sahlgrenska University Hospital (SE)
  • Karolinska University Hospital (SE)
ORCID
Strindberg, Lena
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2003-10-01
Volume
88
Issue
10
Pages
4559-4564
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-030434
OpenAlex
W2000831233
Cited by
98
References
38
Citations by year
2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 7 · 2013: 23 · 2012: 7
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
skeletal muscle, capillary transport, insulin delivery, glucose uptake, oral glucose tolerance test, hyperinsulinemic-euglycemic clamp, muscle blood flow, vasodilation, microdialysis
MeSH terms
Adult, Body Surface Area, Capillaries, Forearm, Glucose, Glucose Tolerance Test, Humans, Hyperinsulinism, Insulin, Male, Regional Blood Flow, Vasodilation, Glucose Clamp Technique, Microdialysis, Muscle, Skeletal

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