CoChat
Sign Up
Cited by 709Ovarian function and disordersReproductive Biology and FertilitySexual Differentiation and Disorders

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Elevated Serum Level of Anti-Mullerian Hormone in Patients with Polycystic Ovary Syndrome: Relationship to the Ovarian Follicle Excess and to the Follicular Arrest

Pigny, Pascal, Merlen, Emilie, Robert, Yann, Cortet-Rudelli, Christine, Decanter, Christine, Jonard, Sophie, Dewailly, Didier·2003·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-030727
Open this paper in CoChat — free account

Abstract

The serum level of anti-Mullerian hormone (AMH), a product from granulosa cells involved in follicle growth, has been shown to correlate tightly with the small antral follicle number (FN) at ultrasonography (U/S) in women who do not have polycystic ovary syndrome (PCOS). Because PCOS is associated with a 2- to 3-fold increase in growing FN, we investigated whether an increased AMH serum level correlates to other hormonal and/or U/S features of PCOS. Serum AMH has been assayed in 104 women (59 symptomatic PCOS, 45 controls) between d 2 and 7 after the last either spontaneous or progestin-induced (in PCOS) menstrual period. Mean serum AMH level was markedly increased in the PCOS group (47.1 +/- 22.9 vs. 20.8 +/- 11.6 pmol/liter in controls; P < 0.0001), an increase in the same order of magnitude as the one of the FN in the 2- to 5-mm range at U/S (12.8 +/- 8.3 vs. 4.8 +/- 1.9; P < 0.0001, respectively). The ratio AMH/FN was similar between the two groups (4.8 +/- 3.4 vs. 4.8 +/- 2.9; P = 0.55). By simple regression, both in PCOS and controls, the AMH level was positively related to the 2- to 5-mm FN at U/S (P < 0.0001 and P < 0.03, respectively), but not to the 6- to 9-mm FN, and was negatively correlated to the serum FSH level (P < 0.02 and P < 0.04, respectively). AMH was also positively related to the serum testosterone and androstenedione levels, in PCOS exclusively (P < 0.0005 and <0.002, respectively). No relationship was found between AMH and age, serum estradiol, inhibin B, and LH levels in both groups. After multiple regression only the 2- to 5-mm FN remained significantly related to AMH in PCOS whereas testosterone, androstenedione, and FSH were no longer. In conclusion, the assay of the serum AMH may represent an important breakthrough in the diagnosis and in the understanding of PCOS. Our data suggest that the increase of AMH serum level in PCOS is the consequence of the androgen-induced excess in small antral FN and that each follicle produces a normal amount of AMH. We hypothesize that an increased AMH tone within the cohort could be involved in the follicular arrest of PCOS, by interacting negatively with FSH at the time of selection.

Overview

Integrity signals

Registry

Crossref · 10.1210/jc.2003-030727

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 28 references

Cited by

Sorted by citations

Items 401–500 of 709

Related

See all

Metadata

Authors
Pigny, P., Merlen, E., Robert, Y., Cortet-Rudelli, C., Decanter, C., Jonard, S., & Dewailly, D.
Affiliations
  • Laboratory of Endocrinology (P.P.), 59037 Lille, France;
  • Clinique Marc Linquette; Departments of Endocrine Gynaecology and Reproductive Medicine (E.M., C.D., S.J., D.D.), 59037 Lille, France;
  • Hôpital Jeanne de Flandre (FR)
  • Department of Diabetology and Endocrinology (C.C.-R.), Centre Hospitalier Régional Universitaire de Lille, 59037 Lille, France
Corresponding author
Dewailly, Didier
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2003-12-01
Volume
88
Issue
12
Pages
5957-5962
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-030727
OpenAlex
W2153731002
Cited by
709
References
28
Citations by year
2026: 18 · 2025: 20 · 2024: 34 · 2023: 25 · 2022: 45 · 2021: 45 · 2020: 30 · 2019: 41 · 2018: 38 · 2017: 37 · 2016: 47 · 2015: 33 · 2014: 37 · 2013: 43 · 2012: 38
FWCI
10.40
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
anti-Müllerian hormone, polycystic ovary syndrome, antral follicle count, follicle-stimulating hormone, testosterone, androstenedione, granulosa cells, ovarian reserve, folliculogenesis, ovarian ultrasonography, inhibin B, estradiol, luteinizing hormone, progestins
MeSH terms
Adult, Female, Glycoproteins, Ovarian Follicle, Hormones, Humans, Immunoassay, Obesity, Polycystic Ovary Syndrome, Testicular Hormones, Ultrasonography, Case-Control Studies, Anti-Mullerian Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review