Androgens stimulate early stages of follicular growth in the primate ovary

Vendola, K A; Zhou, J; Adesanya, O O; Weil, S J; Bondy, C A

doi:10.1172/jci2081

Cited by 712Ovarian function and disordersReproductive Biology and FertilityReproductive Physiology in Livestock

Androgens stimulate early stages of follicular growth in the primate ovary

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Vendola, K A, Zhou, J, Adesanya, O O, Weil, S J, Bondy, C A·1998·Journal of Clinical Investigation

DOI 10.1172/jci2081PMC PMC508852

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Abstract

The concept that androgens are atretogenic, derived from murine ovary studies, is difficult to reconcile with the fact that hyperandrogenic women have more developing follicles than normal-cycling women. To evaluate androgen's effects on primate follicular growth and survival, normal-cycling rhesus monkeys were treated with placebo-, testosterone-(T), or dihydrotestosterone-sustained release implants, and ovaries were taken for histological analysis after 3-10 d of treatment. Growing preantral and small antral follicles up to 1 mm in diameter were significantly and progressively increased in number and thecal layer thickness in T-treated monkeys from 3-10 d. Granulosa and thecal cell proliferation, as determined by immunodetection of the Ki67 antigen, were significantly increased in these follicles. Preovulatory follicles (> 1 mm), however, were not increased in number in androgen-treated animals. Follicular atresia was not increased and there were actually significantly fewer apoptotic granulosa cells in the T-treated groups. Dihydrotestosterone treatment had identical effects, indicating that these growth-promoting actions are mediated by the androgen receptor. These findings show that, over the short term at least, androgens are not atretogenic and actually enhance follicular growth and survival in the primate. These new data provide a plausible explanation for the pathogenesis of "polycystic" ovaries in hyperandrogenism.

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Direct actions of androgen, estrogen and anti-Müllerian hormone on primate secondary follicle development in the absence of FSH in vitro
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Authors: Vendola, K. A., Zhou, J., Adesanya, O. O., Weil, S. J., & Bondy, C. A.
Affiliations: National Institutes of Health (US)
ORCID: Zhou, J
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1998-06-15
Volume: 101
Issue: 12
Pages: 2622-2629
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci2081
PMC: PMC508852
OpenAlex: W2114124243
Cited by: 712
References: 33
Citations by year: 2026: 12 · 2025: 10 · 2024: 19 · 2023: 17 · 2022: 22 · 2021: 44 · 2020: 24 · 2019: 33 · 2018: 31 · 2017: 61 · 2016: 26 · 2015: 51 · 2014: 38 · 2013: 40 · 2012: 40
FWCI: 7.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
Keywords: androgens, folliculogenesis, follicular atresia, rhesus monkeys, testosterone, dihydrotestosterone, androgen receptor, granulosa cell proliferation, Ki-67, apoptosis, preantral follicles, polycystic ovary syndrome, hyperandrogenism, ovary
MeSH terms: Androgens, Animals, Cell Count, Cell Division, Female, Ovarian Follicle, Macaca mulatta, Organ Size, Ovary, Cell Death

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Androgens stimulate early stages of follicular growth in the primate ovary

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