The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
The Prospective Association of Serum Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-1 Levels with All Cause and Cardiovascular Disease Mortality in Older Adults: The Rancho Bernardo Study
Abstract
The IGF system has been implicated in cardiovascular disease (CVD) development. The prospective association of serum IGF-I and IGF-binding protein-1 (IGFBP-1) with all cause, ischemic heart disease (IHD), and non-IHD CVD mortality was examined in 633 men and 552 nonestrogen-using postmenopausal women, aged 51-98 yr (mean, 74 yr) in 1988-1992, who were followed through July 2001 (96% follow-up). During the 9- to 13-yr follow-up, there were 522 deaths; 224 were attributed to CVD, and 105 were caused by IHD. IGF-I and IGFBP-1 were independently and jointly related to risk of IHD mortality. In a proportional hazards model including both IGF-I and IGFBP-1 and adjusting for CVD risk factors, the relative risk of IHD mortality was 38% higher for every 40 ng/ml (1 SD) decrease in IGF-I (95% confidence interval, 1.09-1.76; P = 0.005) and 3.11 times greater for those in the lowest quintile of IGFBP-1 (95% confidence interval, 1.74-5.56; P < 0.001) compared with those with higher IGFBP-1 levels. IGF-I and IGFBP-1 (alone or in combination) were not related to risk of all cause or non-IHD CVD mortality. We conclude that low baseline levels of IGF-I and IGFBP-1 increase the risk of fatal IHD among elderly men and women independent of prevalent IHD and CVD risk factors.
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“a series of observational studies have reported inconsistent associations (37-41)”
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How good a marker is insulin level for insulin resistance?
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Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503
Bernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.005 · Cited by 920
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy
Yoshida, T., & Delafontaine, P. (2020) · Cells · doi:10.3390/cells9091970 · Cited by 772
Calorie restriction and cancer prevention: metabolic and molecular mechanisms
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“Nevertheless, even if GH and/or IGF-1 deficiencies may decrease cancer risk, it is well known that low levels of IGF-1 are associated with increased obesity and heart disease in people who are not restricting calorie intake (111).”
BackgroundAnabolic Deficiency in Men With Chronic Heart Failure
Jankowska, E. A., Biel, B., Majda, J., Szklarska, A., Łopuszańska-Dawid, M., Medraś, M., Anker, S. D., Banasiak, W., Poole-Wilson, P. A., & Ponikowski, P. P. (2006) · Circulation · doi:10.1161/circulationaha.106.649426 · Cited by 375
Metadata
- Authors
- Laughlin, G. A., Barrett-Connor, E., Criqui, M. H., & Kritz-Silverstein, D.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Barrett-Connor, Elizabeth
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-01
- Volume
- 89
- Issue
- 1
- Pages
- 114-120
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2115525455
- Cited by
- 374
- References
- 40
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 9 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 17 · 2018: 8 · 2017: 19 · 2016: 13 · 2015: 10 · 2014: 13 · 2013: 12 · 2012: 26
- FWCI
- 15.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG07181)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031801, DK-31801)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin-like growth factor I, IGF-binding protein-1, cardiovascular mortality, ischemic heart disease mortality, all-cause mortality, older adults, postmenopausal women, IGF system, cardiovascular risk markers
- MeSH terms
- Age Factors, Aged, Blood Pressure, Cardiovascular Diseases, Cholesterol, Female, Humans, Insulin-Like Growth Factor I, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Pregnancy Proteins, Prospective Studies, Risk Factors, Sex Factors, Triglycerides, Body Mass Index, Myocardial Ischemia, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 1
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