The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Plasma Resistin Concentrations Measured by Enzyme-Linked Immunosorbent Assay Using a Newly Developed Monoclonal Antibody Are Elevated in Individuals with Type 2 Diabetes Mellitus
Abstract
Resistin is an adipocyte-derived peptide that might play a role in obesity and insulin resistance. However, its role in humans is largely unclear. Although many studies have measured the expression of human resistin in tissues, the circulating concentrations of resistin and its relation to metabolic parameters in humans are unknown. We developed an ELISA for human resistin and measured plasma concentrations in aged individuals with or without type 2 diabetes mellitus. To validate the results of plasma resistin concentrations in our subjects, plasma adiponectin concentrations were also determined, which were higher in nondiabetic subjects than in type 2 diabetic patients and correlated with the homeostasis model assessment for insulin resistance (HOMA-IR). Log-transformed plasma resistin concentrations (log-resistin) were higher in diabetic patients compared with normal individuals (0.50 +/- 0.39 vs. 0.28 +/- 0.51 ng/ml; P < 0.001), and this difference was significant after controlling for gender and body mass index. Log-resistin did not show a significant correlation with HOMA-IR, waist circumference, body mass index, blood pressure, or total cholesterol. The plasma glucose concentration was an independent factor associated with log-resistin. In conclusion, plasma resistin concentrations are elevated in patients with type 2 diabetes, but are not associated with insulin resistance or obesity.
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Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176
Cited by
Resistin Is an Inflammatory Marker of Atherosclerosis in Humans
Reilly, M. P., Lehrke, M., Wolfe, M. L., Rohatgi, A., Lazar, M. A., & Rader, D. J. (2005) · Circulation · doi:10.1161/01.cir.0000155620.10387.43 · Cited by 911
Fuster, J. J., Ouchi, N., Gokce, N., & Walsh, K. (2016) · Circulation Research · doi:10.1161/circresaha.115.306885 · Cited by 664
Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relationships in Obesity
Vendrell, J., Broch, M., Vilarrasa, N., Molina, A., Gómez, J. M., Gutiérrez, C., Simón, I., Soler, J., & Richart, C. (2004) · Obesity Research · doi:10.1038/oby.2004.118 · Cited by 554
Silswal, N., Singh, A. K., Aruna, B., Mukhopadhyay, S., Ghosh, S., & Ehtesham, N. Z. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.202 · Cited by 540
Koerner, A., Kratzsch, J., & Kiess, W. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.008 · Cited by 471
Metadata
- Authors
- Youn, B.-S., Yu, K.-Y., Park, H. J., Lee, N. S., Min, S. S., Youn, M. Y., Cho, Y. M., Park, Y. J., Kim, S. Y., Lee, H. K., & Park, K. S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-01
- Volume
- 89
- Issue
- 1
- Pages
- 150-156
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2126241207
- Cited by
- 207
- References
- 5
- FWCI
- 16.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Youn, B.-S., Yu, K.-Y., Park, H. J., Lee, N. S., Min, S. S., Youn, M. Y., Cho, Y. M., Park, Y. J., Kim, S. Y., Lee, H. K., & Park, K. S. (2004). Plasma Resistin Concentrations Measured by Enzyme-Linked Immunosorbent Assay Using a Newly Developed Monoclonal Antibody Are Elevated in Individuals with Type 2 Diabetes Mellitus. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2003-031121
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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