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Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway

Silswal, Nirupama, Singh, Anil K., Aruna, Battu, Mukhopadhyay, Sangita, Ghosh, Sudip, Ehtesham, Nasreen Z.·2005·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2005.06.202
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Abstract

Resistin, a recently discovered 92 amino acid protein involved in the development of insulin resistance, has been associated with obesity and type 2 diabetes. The elevated serum resistin in human diabetes is often associated with a pro-inflammatory milieu. However, the role of resistin in the development of inflammation is not well understood. Addition of recombinant human resistin protein (hResistin) to macrophages (both murine and human) resulted in enhanced secretion of pro-inflammatory cytokines, TNF-alpha and IL-12, similar to that obtained using 5 microg/ml lipopolysaccharide. Both oligomeric and dimeric forms of hResistin were able to activate these cytokines suggesting that the inflammatory action of resistin is independent of its conformation. Heat denatured hResistin abrogated cytokine induction while treatment of recombinant resistin with polymyxin B agarose beads had no effect thereby ruling out the role of endotoxin in the recombinant hResistin mediated cytokine induction. The pro-inflammatory nature of hResistin was further evident from the ability of this protein to induce the nuclear translocation of NF-kappaB transcription factor as seen from electrophoretic mobility shift assays. Induction of TNF-alpha in U937 cells by hResistin was markedly reduced in the presence of either dominant negative IkappaBalpha plasmid or PDTC, a pharmacological inhibitor of NF-kappaB. A protein involved in conferring insulin resistance is also a pro-inflammatory molecule that has…

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Research works printed but not linked: 24

  1. Steppan, 2001, The hormone resistin links obesity to diabetes, Nature, 409, 307, 10.1038/35053000 · DOI · Paper page
  2. Youn, 2004, Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with Type 2 Diabetes Mellitus, J. Clin. Endocrinol. Metab., 89, 150, 10.1210/jc.2003-031121 · DOI
  3. Hotamisligil, 1993, Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance, Science, 259, 87, 10.1126/science.7678183 · DOI · Paper page
  4. Lehrke, 2004, Inflamed about obesity, Nat. Med., 10, 126, 10.1038/nm0204-126 · DOI
  5. Bokarewa, 2005, Resistin, an adipokine with potent proinflammatory properties, J. Immunol., 174, 5789, 10.4049/jimmunol.174.9.5789 · DOI
  6. Lappas, 2005, Leptin and adiponectin stimulate the release of pro-inflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via NF-{kappa} B, PPAR-{gamma} and ERK 1/2, Endocrinology, 10.1210/en.2005-0406 · DOI
  7. Moller, 2003, Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation, Int. J. Obes. Relat. Metab. Disord., 3, 17, 10.1038/sj.ijo.0802494 · DOI
  8. Song, 2003, Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules, Biochem. Biophys. Res. Commun., 299, 291, 10.1016/S0006-291X(02)02551-2 · DOI
  9. Ghosh, 2003, The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications, Gene, 305, 27, 10.1016/S0378-1119(02)01213-1 · DOI
  10. Stejskal, 2003, Resistin concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease, Biomed. Pap. Med. Fac. Univ. Palacky Olomouc. Czech Repub., 147, 63, 10.5507/bp.2003.009 · DOI
  11. Frankenberger, 1994, Constitutive nuclear NF-kappa B in cells of the monocyte lineage, Biochem. J., 304, 87, 10.1042/bj3040087 · DOI
  12. Collart, 1990, Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B, Mol. Cell. Biol., 10, 1498, 10.1128/MCB.10.4.1498 · DOI
  13. Aruna, 2003, Human recombinant resistin protein displays a tendency to aggregate by forming intermolecular disulfide linkages, Biochemistry, 42, 10554, 10.1021/bi034782v · DOI
  14. Raghu, 2004, Dimerization of human recombinant resistin involves covalent and noncovalent interactions, Biochem. Biophys. Res. Commun., 313, 642, 10.1016/j.bbrc.2003.11.156 · DOI
  15. Mukhopadhyay, 2002, Macrophage effector functions controlled by Bruton’s tyrosine kinase are more crucial for microfilarial clearance than the cytokine balance of T cell responses, J. Immunol., 168, 2914, 10.4049/jimmunol.168.6.2914 · DOI
  16. Dignam, 1983, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nucleic Acids Res., 11, 1475, 10.1093/nar/11.5.1475 · DOI
  17. Darnay, 1999, Activation of NF-B by RANK requires Tumor Necrosis Factor Receptor-associated factor (TRAF) 6 and NF-B inducing kinase. Identification of a novel TRAF6 interacting motif, J. Biol. Chem., 274, 7724, 10.1074/jbc.274.12.7724 · DOI
  18. Sarkar, 2003, Alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages, FEBS Lett., 23, 286, 10.1016/S0014-5793(03)01029-9 · DOI
  19. Kaser, 2003, Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro, Biochem. Biophys. Res. Commun., 309, 286, 10.1016/j.bbrc.2003.07.003 · DOI
  20. Perez, 1990, A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to cell contact, Cell, 63, 251, 10.1016/0092-8674(90)90158-B · DOI
  21. Hoffmann, 1994, Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance, Endocrinology, 134, 264, 10.1210/endo.134.1.8275942 · DOI
  22. Yang, 2004, Autoimmune diabetes is blocked in Stat4-deficient mice, J. Autoimmun., 22, 191, 10.1016/j.jaut.2003.08.006 · DOI
  23. Hotamisligil, 1994, Tumor necrosis factor-α: a key component of the obesity-diabetes link, Diabetes, 43, 1271, 10.2337/diab.43.11.1271 · DOI
  24. Lehrke, 2004, An inflammatory cascade leading to hyperresistinemia in humans, PloS Med., 1, e45, 10.1371/journal.pmed.0010045 · DOI

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Metadata

Authors
Silswal, N., Singh, A. K., Aruna, B., Mukhopadhyay, S., Ghosh, S., & Ehtesham, N. Z.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2005-09
Volume
334
Issue
4
Pages
1092-1101
ISSN
0006-291X
DOI
10.1016/j.bbrc.2005.06.202
Cited by
540
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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