Adipocytokines: leptin—the classical, resistin—the controversical, adiponectin—the promising, and more to come
Abstract
With the growing prevalence of obesity, scientific interest in the biology of adipose tissue has been extended to the secretory products of adipocytes, since they are increasingly shown to affect several aspects in the pathogenesis of obesity-related diseases. The cloning of the ob gene is consistent with this concept and suggests that body fat content in adult rodents is regulated by a negative feedback loop centred in the hypothalamus. In recent years, a number of additional signalling molecules secreted by adipose tissue have been discovered, commonly referred to as 'adipocytokines'. Among these, adiponectin is perhaps the most interesting and promising compound for the clinician since it has profound protective actions in the pathogenesis of diabetes and cardiovascular disease. Adiponectin is low in obese subjects and, in particular, insulin-resistant patients. In contrast, resistin seems to be of greater relevance in relation to the immune stress response than in the regulation of glucose homeostasis. However, inflammatory processes have recently been connected with the development of atherosclerosis. Finally, little is known regarding the clinical relevance of visfatin. Recent research has revealed many functions of adipocytokines extending far beyond metabolism, such as immunity, cancer and bone formation. This report aims to review some of the recent topics of adipocytokine research that may be of particular importance.
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Inflammatory molecules are likely candidates linking adipose tissue to metabolic, cardiovascular, hepatic and thrombotic complications and certain cancers in obesity.
“Inflammatory molecules are likely candidates exerting a molecular link between the adipose tissue and the metabolic, cardiovascular, hepatic and thrombotic complications, and certain cancer types occurring in conjunction with or as a consequence of human obesity.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [98]
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- Authors
- Koerner, A., Kratzsch, J., & Kiess, W.
- Affiliations
- Leipzig University (DE)
- University Hospital Leipzig (DE)
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 19
- Issue
- 4
- Pages
- 525-546
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W1973692442
- Cited by
- 471
- References
- 179
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 19 · 2020: 4 · 2019: 11 · 2018: 21 · 2017: 15 · 2016: 22 · 2015: 27 · 2014: 33 · 2013: 33 · 2012: 37
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipokines, leptin, resistin, adiponectin, visfatin, obesity, adipose tissue, insulin resistance, diabetes mellitus, cardiovascular disease, atherosclerosis, inflammation, immune response, cancer, bone formation
- MeSH terms
- Adipose Tissue, Animals, Cardiovascular Diseases, Diabetes Mellitus, Humans, Insulin Resistance, Cytokines, Leptin, Mice, Adiponectin, Resistin, Nicotinamide Phosphoribosyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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