The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Abstract
Given the extreme increase in prediabetes, type 2 diabetes, and the potential for metabolic syndrome in obese youth, identifying simplified indexes for assessing stimulated insulin sensitivity is critical. The purpose of this study was validation of two surrogate indexes of insulin sensitivity determined from the oral glucose tolerance test (OGTT): the composite whole body insulin sensitivity index (WBISI) and the insulin sensitivity index (ISI). An obese population (aged 8-18 yr) of normal and impaired glucose tolerance individuals was studied. One group (n = 38) performed both the euglycemic-hyperinsulinemic clamp and OGTT for comparison of insulin sensitivity measurements as well as (1)H-magnetic resonance spectroscopy estimates of intramyocellular lipid content. Another larger (n = 368) cohort participated only in an OGTT. Both the WBISI and ISI represented good estimates (r = 0.78 and 0.74; P < 0.0005) for clamp-derived insulin sensitivity (glucose disposed, M-value), respectively. In the large cohort, the surrogate indexes demonstrated the shift toward poorer function and increased risk profile as a function of insulin resistance. Additionally, the WBISI and ISI correlated with intramyocellular lipid content (r = -0.74 and -0.71; P < 0.0001), a tissue marker for insulin resistance. Insulin sensitivity can be estimated using plasma glucose and insulin responses derived from the OGTT in obese youth with normal and impaired glucose tolerance.
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“Whole-body insulin sensitivity index (WBISI) is an insulin sensitivity measure that has been validated in obese children and adolescents (15)”
From Sleep architecture and glucose and insulin homeostasis in obese adolescents (2011) · cites this paper as [15]
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“Homeostasis model assessment of IR (HOMA-IR) is a validated measure of insulin sensitivity (15)”
From Sleep architecture and glucose and insulin homeostasis in obese adolescents (2011) · cites this paper as [15]
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Cites
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Comparing correlated correlation coefficients
Meng, X.-L., Rosenthal, R., & Rubin, D. B. (1992) · Psychological Bulletin · doi:10.1037/0033-2909.111.1.172 · Cited by 2,472
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
Prevalence of impaired glucose tolerance among children and adolescents with marked obesity
Sinha, R., Fisch, G., Teague, B., Tamborlane, W. V., Banyas, B., Allen, K., Savoye, M., Rieger, V., Taksali, S., Barbetta, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012578 · Cited by 1,709
Self-citationYu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179
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Keskin, M., Kurtoğlu, S., Kendırcı, M., Atabek, M. E., & Yazıcı, C. (2005) · PEDIATRICS · doi:10.1542/peds.2004-1921 · Cited by 1,089
August, G. P., Caprio, S., Fennoy, I., Freemark, M., KAUFMAN, F. R., Lustig, R. H., Silverstein, J. H., Speiser, P., Styne, D. M., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2458 · Cited by 518
Nassis, G. P., Papantakou, K., Skenderi, K., Triandafillopoulou, M., Kavouras, S. A., Yannakoulia, M., Chrousos, G. P., & Sidossis, L. S. (2005) · Metabolism · doi:10.1016/j.metabol.2005.05.013 · Cited by 470
Obesity in Children and Adolescents
Cali, A. M. G., & Caprio, S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1363 · Cited by 453
Prevalence and Determinants of Insulin Resistance Among U.S. Adolescents
Lee, J. M., Okumura, M. J., Davis, M. M., Herman, W. H., & Gurney, J. G. (2006) · Diabetes Care · doi:10.2337/dc06-0709 · Cited by 437
Metadata
- Authors
- Yeckel, C. W., Weiss, R., Dziura, J., Taksali, S. E., Dufour, S., Burgert, T. S., Tamborlane, W. V., & Caprio, S.
- Affiliations
- Department of Pediatrics (C.W.Y., R.W., S.E.T., T.S.B., W.V.T., S.C.), New Haven, Connecticut 06520
- Children’s and Adult General Clinical Research Centers (J.D.), New Haven, Connecticut 06520
- Howard Hughes Medical Institute (US)
- Corresponding author
- Caprio, Sonia
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-03-01
- Volume
- 89
- Issue
- 3
- Pages
- 1096-1101
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2014004380
- Cited by
- 352
- References
- 21
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 14 · 2022: 20 · 2021: 14 · 2020: 15 · 2019: 10 · 2018: 15 · 2017: 14 · 2016: 12 · 2015: 10 · 2014: 17 · 2013: 22 · 2012: 18
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR000125, M01RR006022, MO-1 RR00125, MO1 RR 06022)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD028016, K24HD001464, R01HD040787)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- insulin sensitivity, insulin sensitivity index, oral glucose tolerance test, childhood obesity, adolescents, insulin resistance, impaired glucose tolerance, hyperinsulinemic-euglycemic clamp, intramyocellular lipid, type 2 diabetes risk, prediabetes, metabolic syndrome
- MeSH terms
- Adolescent, Child, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Male, Obesity, Risk Factors, Severity of Illness Index, Glucose Clamp Technique, Feedback, Physiological, Lipid Metabolism
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