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Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents

Yeckel, Catherine W., Weiss, Ram, Dziura, James, Taksali, Sara E., Dufour, Sylvie, Burgert, Tania S., Tamborlane, William V., Caprio, Sonia·2004·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2003-031503

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Abstract

Given the extreme increase in prediabetes, type 2 diabetes, and the potential for metabolic syndrome in obese youth, identifying simplified indexes for assessing stimulated insulin sensitivity is critical. The purpose of this study was validation of two surrogate indexes of insulin sensitivity determined from the oral glucose tolerance test (OGTT): the composite whole body insulin sensitivity index (WBISI) and the insulin sensitivity index (ISI). An obese population (aged 8-18 yr) of normal and impaired glucose tolerance individuals was studied. One group (n = 38) performed both the euglycemic-hyperinsulinemic clamp and OGTT for comparison of insulin sensitivity measurements as well as (1)H-magnetic resonance spectroscopy estimates of intramyocellular lipid content. Another larger (n = 368) cohort participated only in an OGTT. Both the WBISI and ISI represented good estimates (r = 0.78 and 0.74; P < 0.0005) for clamp-derived insulin sensitivity (glucose disposed, M-value), respectively. In the large cohort, the surrogate indexes demonstrated the shift toward poorer function and increased risk profile as a function of insulin resistance. Additionally, the WBISI and ISI correlated with intramyocellular lipid content (r = -0.74 and -0.71; P < 0.0001), a tissue marker for insulin resistance. Insulin sensitivity can be estimated using plasma glucose and insulin responses derived from the OGTT in obese youth with normal and impaired glucose tolerance.

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Authors: Yeckel, C. W., Weiss, R., Dziura, J., Taksali, S. E., Dufour, S., Burgert, T. S., Tamborlane, W. V., & Caprio, S.
Affiliations: Department of Pediatrics (C.W.Y., R.W., S.E.T., T.S.B., W.V.T., S.C.), New Haven, Connecticut 06520
Children’s and Adult General Clinical Research Centers (J.D.), New Haven, Connecticut 06520
Howard Hughes Medical Institute (US)
Corresponding author: Caprio, Sonia
ORCID: Weiss, Ram
Dufour, Sylvie
Burgert, Tania S.
Tamborlane, William V.
Caprio, Sonia
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2004-03-01
Volume: 89
Issue: 3
Pages: 1096-1101
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2003-031503
OpenAlex: W2014004380
Cited by: 352
References: 21
Citations by year: 2026: 3 · 2025: 7 · 2024: 7 · 2023: 14 · 2022: 20 · 2021: 14 · 2020: 15 · 2019: 10 · 2018: 15 · 2017: 14 · 2016: 12 · 2015: 10 · 2014: 17 · 2013: 22 · 2012: 18
FWCI: 12.01
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (M01RR000125, M01RR006022, MO-1 RR00125, MO1 RR 06022)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD028016, K24HD001464, R01HD040787)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: insulin sensitivity, insulin sensitivity index, oral glucose tolerance test, childhood obesity, adolescents, insulin resistance, impaired glucose tolerance, hyperinsulinemic-euglycemic clamp, intramyocellular lipid, type 2 diabetes risk, prediabetes, metabolic syndrome
MeSH terms: Adolescent, Child, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Male, Obesity, Risk Factors, Severity of Illness Index, Glucose Clamp Technique, Feedback, Physiological, Lipid Metabolism

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Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents

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