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Cited by 399Thyroid Disorders and TreatmentsCardiovascular Health and Disease PreventionHormonal and reproductive studies

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Effect of Levothyroxine Replacement on Lipid Profile and Intima-Media Thickness in Subclinical Hypothyroidism: A Double-Blind, Placebo- Controlled Study

Monzani, F., Caraccio, N., Kozàkowà, M., Dardano, A., Vittone, F., Virdis, A., Taddei, S., Palombo, C., Ferrannini, E.·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-031669
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Abstract

Subclinical hypothyroidism (sHT) is associated with dyslipidemia and enhanced cardiovascular risk. We assessed carotid artery intima-media thickness (IMT, high-resolution ultrasonography) and lipoprotein profile in 45 sHT patients (aged 37 +/- 11 yr) at baseline and after 6 months of randomized, placebo-controlled L-T(4) replacement. In comparison with 32 age- and sex-matched controls, sHT patients had elevated total and low-density lipoprotein (LDL) cholesterol and ApoB levels (P = 0.002, P = 0.0007, and P = 0.01, respectively) and higher mean-IMT values (P < 0.0001). In stepwise regression analysis, mean-IMT was positively related (r(2) = 0.71, P < 0.0001) to age, TSH, and LDL cholesterol. L-T(4) replacement significantly reduced both total and LDL cholesterol (P < 0.0001 for both) and mean-IMT (by 11%, P < 0.0001). The decrement in IMT was directly related to the decrements of both total cholesterol and TSH (P = 0.02 and P = 0.0001, respectively). We conclude that early carotid artery wall alterations are present in sHT patients. Whether such IMT increase is related to an early atherosclerotic involvement of the arterial wall cannot be clearly decided on the basis of the present results. However, the fact that L-T(4) replacement therapy was able to improve both the atherogenic lipoprotein profile and intima-media thickening suggests that lipid infiltration of arterial wall may represent a major mechanism underlying IMT increase in subclinical hypothyroidism.

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Metadata

Authors
Monzani, F., Caraccio, N., Kozàkowà, M., Dardano, A., Vittone, F., Virdis, A., Taddei, S., Palombo, C., & Ferrannini, E.
Affiliations
University of Pisa (IT)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-05
Volume
89
Issue
5
Pages
2099-2106
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-031669
OpenAlex
W2068309857
Cited by
399
References
48
Citations by year
2026: 7 · 2025: 3 · 2024: 17 · 2023: 6 · 2022: 12 · 2021: 11 · 2020: 24 · 2019: 17 · 2018: 30 · 2017: 28 · 2016: 21 · 2015: 15 · 2014: 27 · 2013: 29 · 2012: 20
FWCI
13.23
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
subclinical hypothyroidism, levothyroxine replacement, lipid profile, LDL cholesterol, apolipoprotein B, intima-media thickness, carotid artery, dyslipidemia, atherosclerosis, thyroid-stimulating hormone, cardiovascular risk
MeSH terms
Adult, Cholesterol, Double-Blind Method, Female, Humans, Hypothyroidism, Lipids, Cholesterol, LDL, Male, Middle Aged, Placebos, Regression Analysis, Thyrotropin, Thyroxine, Ultrasonography, Tunica Intima, Tunica Media

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