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Estrogen Receptor (ER)α and ERβ Are Both Expressed in Human Ejaculated Spermatozoa: Evidence of Their Direct Interaction with Phosphatidylinositol-3-OH Kinase/Akt Pathway
Abstract
Human and animal models have evidenced how estrogen insufficiency is associated with abnormal spermatogenesis and male infertility. We previously demonstrated that estradiol is able to influence both capacitation and acrosome reaction in human ejaculated spermatozoa. It remains to be elucidated whether the biochemical changes induced by estradiol, in a rapid nongenomic way, are mediated by a single estrogen receptor (ER) or by the two ER subtypes, ER alpha and ER beta. In the present study, we have first demonstrated the concomitant expression of ER beta and ER alpha in human ejaculated spermatozoa. By RT-PCR and Southern blot, transcripts of both ERs were detected. Western blot analysis showed ER alpha and ER beta proteins at the same size as the "classical" ERs. The localization of ER alpha and ER beta with the immunocytochemistry shows a differential distribution of the two ER subtypes, the former being prevalently located in the midpiece, but the latter being in the tail. Estradiol has been associated with sperm longevity; however, the mechanism through which estradiol acts in sperm survival was never investigated. Upon estradiol exposure, we observed an enhanced phosphorylation of the proteins involved in the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway like PDK1, Akt, GSK-3, Bcl-2, together with ERK1/2, which was also involved in cell survival signals. Moreover, such phosphorylations were reduced in the presence of ICI 182, 780, addressing the role of estradiol and ERs in sperm survival. For instance we have provided, for the first time, a different interaction of the two ERs with the PI3K/Akt pathway, because ER alpha interacts with the p55 regulatory subunit of PI3K, whereas ER beta interacts with Akt1. However, it still remains to be elucidated whether the functional role of each of the ER subtypes in sperm survival signaling is redundant or distinct.
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“Pregnenolone, the precursor of androgens, estrogens, progesterone, mineralocorticoids, and glucocorticoids [15], regulates gene expression via a nuclear receptor-mediated genomic pathway and via a transient receptor potential (TRP) cation channels-mediated nongenomic pathway [16].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [16]
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Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
The phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
ERβ: Identification and characterization of a novel human estrogen receptor
Mosselman, S., Polman, J., & Dijkema, R. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00782-x · Cited by 2,269
Lamb, D. J. (2000) · Journal of Andrology · doi:10.1002/j.1939-4640.2000.tb03272.x · Cited by 2,081
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Simoncini, T., Hafezi‐Moghadam, A., Brazil, D. P., Ley, K. F., Chin, W. W., & Liao, J. K. (2000) · Nature · doi:10.1038/35035131 · Cited by 1,436
Effect of testosterone and estradiol in a man with aromatase deficiency
Carani, C., Qin, K., Simoni, M., Faustini-Fustini, M., Serpente, S., Boyd, J., Korach, K. S., & Simpson, E. R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370204 · Cited by 1,151
A role for oestrogens in the male reproductive system
Hess, R. A., Bunick, D., Lee, K., Bahr, J. M., Taylor, J. A., Korach, K. S., & Lubahn, D. B. (1997) · Nature · doi:10.1038/37352 · Cited by 894
Eddy, E. M., Washburn, T. F., Bunch, D. O., Goulding, E. H., Gladen, B. C., Lubahn, D. B., & Korach, K. S. (1996) · Endocrinology · doi:10.1210/endo.137.11.8895349 · Cited by 869
Fisher, C. R., Graves, K. H., Parlow, A. F., & Simpson, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6965 · Cited by 867
O’Donnell, L., Robertson, K. M.-P., Jones, M. E. E., & Simpson, E. R. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.3.0431 · Cited by 854
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Aquila, S., Guido, C., Middea, E., Perrotta, I. D., Bruno, R., PELLEGRINO, M. A., & Andò, S. (2009) · Cited by 459
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Solakidi, S., Psarra, A. G., Nikolaropoulos, S., & Sekeris, C. E. (2005) · Human Reproduction · doi:10.1093/humrep/dei267 · Cited by 205
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Self-citationAquila, S., Guido, C., Middea, E., Perrotta, I. D., Bruno, R., PELLEGRINO, M. A., & Andò, S. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-140 · Cited by 119
Self-citationNovel insights into the genetic and epigenetic paternal contribution to the human embryo
Kumar, M., Kumar, K., Jain, S., Hassan, T., & Dada, R. (2013) · Clinics · doi:10.6061/clinics/2013(sup01)02 · Cited by 123
Aromatase, oestrogens and human male reproduction
Carreau, S., Wołczyński, S., & Galeraud-Denis, I. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0113 · Cited by 120
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Hess, R. A., & Carnes, K. I. (2004) · Cited by 113
Estrogen, a female hormone involved in spermatogenesis
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Moro, L., Reineri, S., Piranda, D., Pietrapiana, D., Lova, P., Bertoni, A., Graziani, A., Defilippi, P., Canobbio, I., Torti, M., et al. (2004) · Blood · doi:10.1182/blood-2003-11-3840 · Cited by 103
Agirregoitia, E., Valdivia, A., Carracedo, A., Casis, L., Gil, J., Subirán, N., Ochoa, C., & Irazusta, J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0599 · Cited by 101
Geoffroy-Siraudin, C., Loundou, A., Romain, F., Achard, V., Courbière, B., Perrard, M., Durand, P., & Guichaoua, M.-R. (2012) · Asian Journal of Andrology · doi:10.1038/aja.2011.173 · Cited by 107
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Aquila, S., Middea, E., Catalano, S., Marsico, S., Lanzino, M., Casaburi, I., Barone, I., Bruno, R., Zupo, S., & Andò, S. (2007) · Human Reproduction · doi:10.1093/humrep/dem243 · Cited by 97
Self-citationMitogen activated protein kinases (MAPKs) as regulators of spermatogenesis and spermatozoa functions
Almog, T., & Naor, Z. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.11.011 · Cited by 94
Aquila, S., Guido, C., Perrotta, I. D., Tripepi, S., Nastro, A., & Andò, S. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00975.x · Cited by 84
Self-citationThe CB2 cannabinoid receptor regulates human sperm cell motility
Agirregoitia, E., Carracedo, A., Subirán, N., Valdivia, A., Agirregoitia, N., Peralta, L., Velasco, G., & Irazusta, J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.153 · Cited by 85
Estrogens: a new player in spermatogenesis.
Carreau, S., Silandre, D., Bois, C., Bouraima, H., Galeraud-Denis, I., & Delalande, C. (2007) · PubMed · doi:10.5603/4544 · Cited by 83
Dworatzek, E., Mahmoodzadeh, S., Schubert, C., Westphal, C., Leber, J., Kusch, A., Kararigas, G., Fliegner, D., Moulin, M., Ventura-Clapier, R., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu065 · Cited by 79
Yeste, M., Estrada, E., del Alamo, M. M. R., Bonet, S., Rigau, T., & Rodríguez-Gil, J. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090887 · Cited by 79
Estrogens – new players in spermatogenesis
Carreau, S., Bouraïma-Lelong, H., & Delalande, C. (2011) · Reproductive Biology · doi:10.1016/s1642-431x(12)60065-5 · Cited by 80
Dostalova, P., Žatecká, E., & Komrsková, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050904 · Cited by 80
Aromatase in testis: Expression and role in male reproduction
Lambard, S., Silandre, D., Delalande, C., Galeraud-Denis, I., Bourguiba, S., & Carreau, S. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.04.020 · Cited by 80
Biology of Reproduction Highlights …
Schuel, H., & Burkman, L. J. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.043273 · Cited by 75
Estrogen signaling in testicular cells
Carreau, S., Bois, C., Zanatta, L. C. B., Silva, F. R. M. B., Bouraïma-Lelong, H., & Delalande, C. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.06.004 · Cited by 76
Aromatase and estrogens in man reproduction: a review and latest advances
Carreau, S., de Vienne, C. M., & Galeraud-Denis, I. (2008) · Advances in Medical Sciences · doi:10.2478/v10039-008-0022-z · Cited by 76
Guido, C., Panza, S., Santoro, M., Avena, P., Panno, M. L., Perrotta, I. D., Giordano, F., Casaburi, I., Catalano, S., Amicis, F. D., et al. (2012) · Cell Cycle · doi:10.4161/cc.21336 · Cited by 72
Self-citationAquila, S., Guido, C., Santoro, A., Perrotta, I. D., Laezza, C., Bifulco, M., & Andò, S. (2009) · The Anatomical Record · doi:10.1002/ar.21042 · Cited by 71
Self-citationAquila, S., Bonofiglio, D., Gentile, M., Middea, E., Gabriele, S., Belmonte, M., Catalano, S., PELLEGRINO, M. A., & Andò, S. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20807 · Cited by 71
Self-citationLea, R. G., Byers, A. S., Sumner, R. N., Rhind, S. M., Zhang, Z., Freeman, S. L., Moxon, R., Richardson, H. M., Green, M. J., Craigon, J., et al. (2016) · Scientific Reports · doi:10.1038/srep31281 · Cited by 70
Jungnickel, M. K., Sutton, K. A., Wang, Y., & Florman, H. M. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.023 · Cited by 69
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Xu, X., Sun, M., Ye, J., Luo, D., Su, X., Zheng, D., Feng, L., Gao, L., Yu, C., & Guan, Q. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-107835 · Cited by 68
Mutembei, H. M., Goericke‐Pesch, S., Schuler, G. C., & Hoffmann, B. (2005) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2005.00586.x · Cited by 68
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Estrogens and male reproduction: a new concept
Carreau, S., Silandre, D., Bourguiba, S., Hamden, K., Saïd, L., Lambard, S., Galeraud-Denis, I., & Delalande, C. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2007000600003 · Cited by 66
Guido, C., Perrotta, I. D., Panza, S., Middea, E., Avena, P., Santoro, M., Marsico, S., Imbrogno, P., Andò, S., & Aquila, S. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22703 · Cited by 66
Self-citationIn vitro effect of malathion and diazinon on oocytes fertilization and embryo development in porcine
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The in vitro biological activity of Lepidium meyenii extracts
Valentová, K., Buckiová, D., Vladimír Křen, A., Pěknicová, J., Jitka Ulrichová, A., & Šimánek, V. (2006) · Cell Biology and Toxicology · doi:10.1007/s10565-006-0033-0 · Cited by 63
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Effect of estrogens on boar sperm capacitation in vitro
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Cristofaro, P. A., Opal, S. M., Palardy, J. E., Parejo, N. A., Jhung, J. W., Keith, J. C., & Harris, H. A. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000227173.13497.56 · Cited by 61
Zhao, X.-F. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00620-y · Cited by 60
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Self-citationFietz, D., Ratzenböck, C., Hartmann, K., Raabe, O., Kliesch, S., Weidner, W., Klug, J., & Bergmann, M. (2014) · Histochemistry and Cell Biology · doi:10.1007/s00418-014-1216-z · Cited by 57
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Cappello, A. R., Guido, C., Santoro, A., Santoro, M., Capobianco, L., Montanaro, D., Madeo, M., Andò, S., Dolce, V., & Aquila, S. (2012) · Endocrinology · doi:10.1210/en.2011-1562 · Cited by 45
Self-citationRago, V., Rose, D. D., Santoro, M., Panza, S., Malivindi, R., Andò, S., D’Agata, R., & Aquila, S. (2020) · Endocrinology · doi:10.1210/endocr/bqaa031 · Cited by 48
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Potential Involvement of Several Signaling Pathways in Initiation of the Chicken Acrosome Reaction1
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Rago, V., Giordano, F., Brunelli, E., Zito, D., Aquila, S., & Carpino, A. (2014) · Journal of Anatomy · doi:10.1111/joa.12183 · Cited by 39
Self-citationPhysiological action of oestradiol on the acrosome reaction in human spermatozoa
Pilar Vigil, P., Toro, A., & Godoy, A. (2008) · Andrologia · doi:10.1111/j.1439-0272.2007.00814.x · Cited by 39
Shen, Y., Wen, L., Zhang, R., Wei, Z., Shi, N., Xiong, Q., Xia, Q., Xing, Z., Zeng, Z., Niu, H., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14169 · Cited by 39
Šebková, N., Cerna, M., Děd, L., Pěknicová, J., & Komrsková, K. (2011) · Reproduction · doi:10.1530/rep-11-0326 · Cited by 38
Estrogen Receptor α and β Polymorphisms Are Associated With Semen Quality
Lazaros, L. A., Xita, N. V., Kaponis, A. I., Zikopoulos, K. A., Plachouras, N., & Georgiou, I. A. (2010) · Journal of Andrology · doi:10.2164/jandrol.109.007542 · Cited by 38
Aparicio, I. M., Bragado, M. J., Gil, M. C., García‐Herreros, M., González‐Fernández, L., Tapia, J. A., & Garcı́a, L. J. (2006) · Molecular Reproduction and Development · doi:10.1002/mrd.20663 · Cited by 37
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Shaha, C. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09597-4_3 · Cited by 36
Rago, V., Siciliano, L., Aquila, S., & Carpino, A. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-36 · Cited by 36
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Strengthening the effectiveness of patient education: applying principles of adult education.
Padberg, R. M., & Padberg, L. F. (1990) · PubMed · Cited by 35
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Valdivia, A., Cortés, L., Beitia, M., Totorikaguena, L., Agirregoitia, N., Corcóstegui, B., Casis, L., Matorras, R., Irazusta, J., & Agirregoitia, E. (2019) · Reproduction · doi:10.1530/rep-19-0274 · Cited by 34
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Self-citationLee, I.-W., Kuo, P., Su, M., Kuan, L.-C., Hsu, C., & Kuo, P. (2011) · Human Reproduction · doi:10.1093/humrep/der062 · Cited by 32
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Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect
Su, M., Chen, C.-H., Kuo, P., Hsu, C., Lee, I.-W., Pan, H.-A., Chen, Y., & Kuo, P. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.030 · Cited by 29
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Metadata
- Authors
- Aquila, S., Sisci, D., Gentile, M., Middea, E., Catalano, S., Carpino, A., Rago, V., & Andò, S.
- Affiliations
- University of Calabria (IT)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-03
- Volume
- 89
- Issue
- 3
- Pages
- 1443-1451
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1979238526
- Cited by
- 184
- References
- 41
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 5 · 2012: 18
- FWCI
- 13.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università della Calabria
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- estrogen receptor alpha, estrogen receptor beta, estradiol, sperm survival, PI3K/Akt signaling, non-genomic estrogen signaling, sperm capacitation, acrosome reaction, fulvestrant, AKT1, PDK1, glycogen synthase kinase-3, ERK1/2, Bcl-2
- MeSH terms
- Cell Survival, Ejaculation, Estradiol, Humans, Male, Proto-Oncogene Proteins, Receptors, Estrogen, Spermatozoa, Blotting, Southern, Blotting, Western, Gene Expression, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-bcl-2, Phosphatidylinositol 3-Kinases, Mitogen-Activated Protein Kinase 1, Reverse Transcriptase Polymerase Chain Reaction, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Estrogen Receptor alpha, Estrogen Receptor beta, Mitogen-Activated Protein Kinase 3, Proto-Oncogene Proteins c-akt
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