The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Gastric Bypass Surgery for Morbid Obesity Leads to an Increase in Bone Turnover and a Decrease in Bone Mass
Abstract
Little is known about the effects on the skeleton of laparoscopic Roux-en-Y gastric bypass (LRGB) surgery for morbid obesity and subsequent weight loss. We compared 25 patients who had undergone LRGB 11 ± 3 months previously with 30 obese controls matched for age, gender, and menopausal status. Compared with obese controls, patients post LRGB had significantly lower weight (92 ± 16 vs. 133 ± 20 kg; P < 0.001) and body mass index (31 ± 5 vs. 48 ± 7 kg/m2; P < 0.001). Markers of bone turnover were significantly elevated in patients post LRGB compared with controls (urinary N-telopeptide cross-linked collagen type 1, 93 ± 38 vs. 24 ± 11 nmol bone collagen equivalents per mmol creatinine; and osteocalcin, 11.6 ± 3.4 vs. 7.6 ± 3.6 ng/ml; both P < 0.001). Fifteen patients were studied prospectively for an average of 9 months after LRGB. They lost 37 ± 9 kg and had a 29 ± 8% fall in body mass index (both P < 0.001). Urinary N-telopeptide cross-linked collagen type 1 increased by 174 ± 168% at 3 months (P < 0.01) and 319 ± 187% at 9 months (P < 0.01). Bone mineral density decreased significantly at the total hip (7.8 ± 4.8%; P < 0.001), trochanter (9.3 ± 5.7%; P < 0.001), and total body (1.6 ± 2.0%; P < 0.05), with significant decreases in bone mineral content at these sites. In summary, within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term.
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“Vitamin D deficiency is widespread9, 10”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [10]
Citations
Cites
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Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382
KANALEY, J. A., COLBERG, S. R., CORCORAN, M. H., MALIN, S. K., RODRIGUEZ, N. R., CRESPO, C. J., KIRWAN, J. P., & ZIERATH, J. R. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002800 · Cited by 931
Interdisciplinary European Guidelines on Metabolic and Bariatric Surgery
Fried, M., Yumuk, V., Oppert, J., Scopinaro, N., Torres, A., Weiner, R. A., Yashkov, Y. I., & Frühbeck, G. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1079-8 · Cited by 768
“In case of excessive bloating, flatulence and/or foul-smelling stools, the recommended treatments are oral neomycin or metronidazole or pancreatic enzymes (EL A, B, C and D) [18, 83, 195–220].”
BackgroundASMBS Allied Health Nutritional Guidelines for the Surgical Weight Loss Patient
Aills, L., Blankenship, J. D., Buffington, C. K., Furtado, M. M., & Parrott, J. M. (2008) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.03.002 · Cited by 600
“Supplementation with calcium and vitamin D during all weight loss modalities is critical to preventing bone resorption [121].”
BackgroundNutritional Deficiencies following Bariatric Surgery: What Have We Learned?
Bloomberg, R. D., Fleishman, A., Nalle, J. E., Herron, D. M., & Kini, S. U. (2005) · Obesity Surgery · doi:10.1381/0960892053268264 · Cited by 514
Metadata
- Authors
- Coates, P. S., Fernstrom, J. D., Fernstrom, M. H., Schauer, P. R., & Greenspan, S. L.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Schauer, Philip R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-03-01
- Volume
- 89
- Issue
- 3
- Pages
- 1061-1065
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2116196260
- Cited by
- 423
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 1 · 2022: 10 · 2021: 14 · 2020: 25 · 2019: 9 · 2018: 16 · 2017: 23 · 2016: 21 · 2015: 20 · 2014: 33 · 2013: 23 · 2012: 20
- FWCI
- 29.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR000056, M01-RR00056-39)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- laparoscopic Roux-en-Y gastric bypass, morbid obesity, bone turnover, bone mineral density, bone mineral content, bone resorption, osteocalcin, N-telopeptide, weight loss, bariatric surgery
- MeSH terms
- Adult, Bone and Bones, Calcium, Dietary, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Vitamin D, Gastric Bypass, Weight Loss, Bone Density, Bone Remodeling
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