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Cited by 424Bariatric Surgery and OutcomesBone health and osteoporosis researchBone Metabolism and Diseases

The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.

Gastric Bypass Surgery for Morbid Obesity Leads to an Increase in Bone Turnover and a Decrease in Bone Mass

Coates, Penelope S., Fernstrom, John D., Fernstrom, Madelyn H., Schauer, Philip R., Greenspan, Susan L.·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-031756
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Abstract

Little is known about the effects on the skeleton of laparoscopic Roux-en-Y gastric bypass (LRGB) surgery for morbid obesity and subsequent weight loss. We compared 25 patients who had undergone LRGB 11 ± 3 months previously with 30 obese controls matched for age, gender, and menopausal status. Compared with obese controls, patients post LRGB had significantly lower weight (92 ± 16 vs. 133 ± 20 kg; P < 0.001) and body mass index (31 ± 5 vs. 48 ± 7 kg/m2; P < 0.001). Markers of bone turnover were significantly elevated in patients post LRGB compared with controls (urinary N-telopeptide cross-linked collagen type 1, 93 ± 38 vs. 24 ± 11 nmol bone collagen equivalents per mmol creatinine; and osteocalcin, 11.6 ± 3.4 vs. 7.6 ± 3.6 ng/ml; both P < 0.001). Fifteen patients were studied prospectively for an average of 9 months after LRGB. They lost 37 ± 9 kg and had a 29 ± 8% fall in body mass index (both P < 0.001). Urinary N-telopeptide cross-linked collagen type 1 increased by 174 ± 168% at 3 months (P < 0.01) and 319 ± 187% at 9 months (P < 0.01). Bone mineral density decreased significantly at the total hip (7.8 ± 4.8%; P < 0.001), trochanter (9.3 ± 5.7%; P < 0.001), and total body (1.6 ± 2.0%; P < 0.05), with significant decreases in bone mineral content at these sites. In summary, within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term.

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Crossref · 10.1210/jc.2003-031756

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Metadata

Authors
Coates, P. S., Fernstrom, J. D., Fernstrom, M. H., Schauer, P. R., & Greenspan, S. L.
Affiliations
University of Pittsburgh (US)
ORCID
Schauer, Philip R.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-03-01
Volume
89
Issue
3
Pages
1061-1065
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-031756
OpenAlex
W2116196260
Cited by
423
References
34
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 1 · 2022: 10 · 2021: 14 · 2020: 25 · 2019: 9 · 2018: 16 · 2017: 23 · 2016: 21 · 2015: 20 · 2014: 33 · 2013: 23 · 2012: 20
FWCI
29.06
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (M01RR000056, M01-RR00056-39)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
laparoscopic Roux-en-Y gastric bypass, morbid obesity, bone turnover, bone mineral density, bone mineral content, bone resorption, osteocalcin, N-telopeptide, weight loss, bariatric surgery
MeSH terms
Adult, Bone and Bones, Calcium, Dietary, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Vitamin D, Gastric Bypass, Weight Loss, Bone Density, Bone Remodeling

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