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Effects of Exogenous Leptin on Satiety and Satiation in Patients with Lipodystrophy and Leptin Insufficiency
Open accessAbstract
To examine leptin’s role in human appetite regulation, we studied recombinant methionyl human leptin’s effects on satiation and satiety in a model of leptin insufficiency, lipodystrophy. Eight females with hypoleptinemia and lipodystrophy were given sc injections of A-100 (maximal dose, 200% of that predicted to normalize serum leptin) for 4 months. Satiation and satiety were determined before and again during leptin treatment. Satiation was measured as the time to voluntary cessation of eating from a standardized food array after a 12-h fast. Satiety was determined as the time to hunger sufficient to consume a full meal after consumption of a standardized preload. During leptin treatment, satiation time decreased (41.2 ± 18.2 to 19.5 ± 10.6 min; P = 0.01), satiety time increased (62.9 ± 64.8 to 137.8 ± 91.6 min; P = 0.04), energy consumed to produce satiation decreased (2034 ± 405 to 1135 ± 432 kcal or 8.5 ± 1.7 to 4.7 ± 1.8 MJ; P < 0.01), and the amount of food desired in the postabsorptive state decreased (P < 0.02). Ghrelin concentrations also decreased during leptin administration (284.3 ± 127.9 to 140.6 ± 104.5 pmol/liter; P < 0.002). We conclude that increased leptin in patients with lipodystrophy results in less caloric, shorter, more satiating meals and longer-lived satiety. These data support the hypothesis that leptin plays an important, permissive role in human appetite regulation.
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“When patients with lipodystrophy and reduced leptin were placed on r-metHuLeptin, they reported improved satiety and satiation, resulting in ϳ40% reduction of caloric intake (22).”
From Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy (2005) · cites this paper as [22]
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Self-citationLeptin-Replacement Therapy for Lipodystrophy
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“This hypothesis is supported by the decreases in resting energy expenditure observed with leptin administration in patients with lipodystrophies (15).”
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Self-citationLeptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
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Metadata
- Authors
- McDuffie, J. R., Riggs, P. A., Calis, K. A., Freedman, R. J., Oral, E. A., DePaoli, A. M., & Yanovski, J. A.
- Affiliations
- National Institutes of Health (US)
- Nutrition Department (P.A.R.), Maryland 20892
- Drug Information Service, Pharmacy Department (K.A.C.), Warren Grant Magnuson Clinical Center
- Unit on Growth and Obesity, National Institute of Child Health and Human Development (J.R.M., R.J.F., J.A.Y.), Maryland 20892
- Amgen (United States) (US)
- Corresponding author
- Yanovski, Jack A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-09-01
- Volume
- 89
- Issue
- 9
- Pages
- 4258-4263
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC2266890
- OpenAlex
- W2150678858
- Cited by
- 129
- References
- 31
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 10 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- Amgen
- National Institutes of Health (Z99HD999999)
- U.S. Public Health Service
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-54387, R01DK054387)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZO1 HD00641, Z01HD000641)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, lipodystrophy, hypoleptinemia, satiety, satiation, appetite regulation, ghrelin, recombinant human leptin, meal duration, energy intake
- MeSH terms
- Adolescent, Adult, Energy Metabolism, Female, Humans, Lipodystrophy, Satiation, Leptin
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