Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Abstract
C57BL/6J mice with a mutation in the obese ( ob )gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of glucose and insulin. In addition, metabolic rate, body temperature, and activity levels were increased by this treatment. None of these parameters was altered beyond the level observed in lean controls, suggesting that the OB protein normalized the metabolic status of the ob / ob mice. Lean animals injected with OB protein maintained a smaller weight loss throughout the 28-day study and showed no changes in any of the metabolic parameters. These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite.
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Leptin is an adipocyte-derived hormone whose absence in mice and humans causes abnormal energy homeostasis and profound obesity that is ameliorated by leptin treatment.
“Leptin is an adipocyte-derived hormone whose absence in mice (1) and humans (2-4) causes abnormal energy homeostasis and profound obesity that is ameliorated by leptin treatment (5, 6).”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [5]
Leptin administration to leptin-deficient mice or humans ameliorates hyperglycemia and hyperinsulinemia even when differences in food intake are controlled by pair-feeding.
“leptin administration to leptin-deficient mice or humans ameliorates hyperglycemia and hyperinsulinemia (60, 141) even when differences of food intake are controlled by pair-feeding (80, 158).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [141]
Leptin-deficient Lepob/ob mice exhibit profound diabetes that can be fully prevented by low doses of leptin that do not affect body weight and food intake.
“For example, leptin-deficient Lepob/ob mice exhibit profound diabetes that can be fully prevented by low doses of leptin that do not affect body weight and food intake (Pelleymounter et al., 1995).”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Pelleymounter et al., 1995
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- Authors
- Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F.
- Affiliations
- Amgen (United States) (US)
- Venue
- Science
- Published
- 1995-07-28
- Volume
- 269
- Issue
- 5223
- Pages
- 540-543
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060682066
- Cited by
- 4,017
- References
- 6
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 34 · 2023: 38 · 2022: 49 · 2021: 63 · 2020: 54 · 2019: 76 · 2018: 65 · 2017: 79 · 2016: 103 · 2015: 95 · 2014: 132 · 2013: 113 · 2012: 128
- FWCI
- 107.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- obese gene, leptin, ob/ob mice, body weight regulation, obesity, dietary intake, fat mass, glucose, insulin, metabolic rate, body temperature, physical activity, appetite, fat deposition
- MeSH terms
- Adipose Tissue, Analysis of Variance, Animals, Blood Glucose, Body Composition, Body Temperature, Dose-Response Relationship, Drug, Drinking, Eating, Energy Metabolism, Female, Insulin, Mice, Inbred C57BL, Mice, Obese, Motor Activity, Obesity, Oxygen Consumption, Proteins, Recombinant Proteins, Weight Loss, Leptin, Mice
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