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Cited by 753Thyroid Disorders and TreatmentsRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Small Differences in Thyroid Function May Be Important for Body Mass Index and the Occurrence of Obesity in the Population

Knudsen, Nils, Laurberg, Peter, Rasmussen, Lone B., Bülow, Inge, Perrild, Hans, Ovesen, Lars, Jørgensen, Torben·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2004-2225
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Abstract

CONTEXT: Increasing prevalence of overweight in the population is a major concern globally; and in the United States, nearly one third of adults were classified as obese at the end of the 20th century. Few data have been presented regarding an association between variations in thyroid function seen in the general population and body weight. OBJECTIVE: The aim of this study was to investigate the association between thyroid function and body mass index (BMI) or obesity in a normal population. DESIGN: A cross-sectional population study (The DanThyr Study) was conducted. PARTICIPANTS: In all, 4649 participants were investigated, and 4082 were eligible for these analyses after exclusion of subjects with previous or present overt thyroid dysfunction. MAIN OUTCOME MEASURES: The study examined the association between category of serum TSH or serum thyroid hormones and BMI or obesity in multivariate models, adjusting for possible confounding. RESULTS: We found a positive association between BMI and category of serum TSH (P < 0.001) and a negative association between BMI and category of serum free T(4) (P < 0.001). No association was found between BMI and serum free T(3) levels. The difference in BMI between the groups with the highest and lowest serum TSH levels was 1.9 kg/m(2), corresponding to a difference in body weight of 5.5 kg among women. Similarly, the category of serum TSH correlated positively with weight gain during 5 yr (P = 0.04), but no statistically significant association was found with weight gain during 6 months (P = 0.17). There was an association between obesity (BMI > 30 kg/m(2)) and serum TSH levels (P = 0.001). CONCLUSIONS: Our results suggest that thyroid function (also within the normal range) could be one of several factors acting in concert to determine body weight in a population. Even slightly elevated serum TSH levels are associated with an increase in the occurrence of obesity.

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Crossref · 10.1210/jc.2004-2225

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Metadata

Authors
Knudsen, N., Laurberg, P., Rasmussen, L. B., Bülow, I., Perrild, H., Ovesen, L., & Jørgensen, T.
Affiliations
  • Bispebjerg Hospital (DK)
  • Aalborg University Hospital (DK)
Corresponding author
Knudsen, Nils
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-07
Volume
90
Issue
7
Pages
4019-4024
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2004-2225
OpenAlex
W2133682334
Semantic Scholar
20e3a19b8599c2b8587d25dfab6ed083b7ff3e0f
Cited by
753
References
39
Citations by year
2026: 15 · 2025: 28 · 2024: 35 · 2023: 33 · 2022: 41 · 2021: 38 · 2020: 50 · 2019: 49 · 2018: 38 · 2017: 43 · 2016: 46 · 2015: 47 · 2014: 56 · 2013: 47 · 2012: 41
FWCI
10.82
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
thyroid function, body mass index, obesity, serum TSH, free thyroxine, free triiodothyronine, weight gain, subclinical thyroid dysfunction, healthy population
MeSH terms
Adolescent, Adult, Aged, Cross-Sectional Studies, Humans, Middle Aged, Obesity, Thyroid Hormones, Thyrotropin, Body Mass Index

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