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Cited by 132Thyroid Disorders and TreatmentsRegulation of Appetite and ObesityGrowth Hormone and Insulin-like Growth Factors

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

High Circulating Thyrotropin Levels in Obese Women Are Reduced after Body Weight Loss Induced by Caloric Restriction

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Kok, Petra, Roelfsema, Ferdinand, Langendonk, Janneke G., Frölich, Marijke, Burggraaf, Jacobus, Meinders, A. Edo, Pijl, Hanno·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-0920
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Abstract

CONTEXT: Previous clinical studies concerning the impact of body weight loss on single plasma TSH concentration measurements or the TSH response to TRH in obese humans have shown variable results. OBJECTIVE: The objective of this study was to investigate the effect of weight loss induced by caloric restriction on diurnal TSH concentrations and secretion in obese humans. DESIGN: This was a clinical, prospective, crossover study. SETTING: The study was conducted at the Clinical Research Center of Leiden University Medical Center. PARTICIPANTS: Eleven obese premenopausal women (body mass index, 33.3 +/- 0.7 kg/m2) were studied. INTERVENTION: The study intervention was weight loss (50% reduction overweight by caloric restriction). MAIN OUTCOME MEASURE(S): Twenty-four-hour plasma TSH concentrations (10-min intervals) and the 24-h TSH secretion rate, calculated by a waveform-independent deconvolution technique (Pulse), were determined. RESULTS: The 24-h TSH secretion rate was significantly higher in obese women than in normal weight controls, and weight loss was accompanied by diminished TSH release (before weight loss, 43.4 +/- 6.4 mU/liter.24 h; after weight loss, 34.4 +/- 5.9 mU/liter.24 h; P = 0.02). Circulating free T3 levels decreased after weight loss from 4.3 +/- 0.19 to 3.8 +/- 0.14 pmol/liter (P = 0.04). Differences in 24-h TSH release correlated positively with the decline of circulating leptin (r2 = 0.62; P < 0.01). CONCLUSIONS: Elevated TSH secretion in obese women is significantly reduced by diet-induced weight loss. Among various physiological cues, leptin may be involved in this phenomenon. The decreases in TSH and free T3 may blunt energy expenditure in response to long-term calorie restriction, thereby frustrating weight loss attempts of obese individuals.

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Metadata

Authors
Kok, P., Roelfsema, F., Langendonk, J. G., Frölich, M., Burggraaf, J., Meinders, A. E., & Pijl, H.
Affiliations
  • Leiden University Medical Center (NL)
  • Leiden University (NL)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-08
Volume
90
Issue
8
Pages
4659-4663
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-0920
OpenAlex
W2100378640
Cited by
132
References
20
Citations by year
2026: 1 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 11 · 2012: 7
FWCI
2.87
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
thyroid-stimulating hormone, TSH secretion, obesity, weight loss, caloric restriction, leptin, free T3, premenopausal women, energy expenditure, thyroid function
MeSH terms
Adult, Circadian Rhythm, Diet, Reducing, Female, Humans, Obesity, Prospective Studies, Thyrotropin, Weight Loss, Cross-Over Studies, Leptin, Caloric Restriction

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