The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Tissue Thyroid Hormone Levels in Critical Illness
Open accessAbstract
Context: Pronounced alterations in serum thyroid hormone levels occur during critical illness. T3 decreases and rT3 increases, the magnitudes of which are related to the severity of disease. It is unclear whether these changes are associated with decreased tissue T3 concentrations and, thus, reduced thyroid hormone bioactivity. Patients and Study Questions: We therefore investigated, in 79 patients who died after intensive care and who did or did not receive thyroid hormone treatment, whether total serum thyroid hormone levels correspond to tissue levels in liver and muscle. Furthermore, we investigated the relationship between tissue thyroid hormone levels, deiodinase activities, and monocarboxylate transporter 8 expression. Results: Tissue iodothyronine levels were positively correlated with serum levels, indicating that the decrease in serum T3 during illness is associated with decreased levels of tissue T3. Higher serum T3 levels in patients who received thyroid hormone treatment were accompanied by higher levels of liver and muscle T3, with evidence for tissue-specific regulation. Tissue rT3 and the T3/rT3 ratio were correlated with tissue deiodinase activities. Monocarboxylate transporter 8 expression was not related to the ratio of the serum over tissue concentration of the different iodothyronines. Conclusion: Our results suggest that, in addition to changes in the hypothalamus-pituitary-thyroid axis, tissue-specific mechanisms are involved in the reduced supply of bioactive thyroid hormone in critical illness.
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In the citing paper
“This was clearly shown in a study involving patients who were critically ill and received TH treatment [84].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [84]
Experimental — accuracy not yet measuredIn the citing paper
“While serum T3 levels may decline by 30%, which is significant, but still within the so-called “normal range”, tissue T3 may decline by 70–80%, resulting in profound cellular hypothyroidism with normal serum TSH, FT4, and FT3 levels”
From Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report (2017) · cites this paper as [29]
In the citing paper
“As a result, TSH may be a poor indicator of peripheral thyroid levels in the presence of such conditions.”
From Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report (2017) · cites this paper as [29]
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Cites
Intensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977
Self-citationBianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Alterations in thyroid function in patients with systemic illness: the euthyroid sick syndrome
WARTOFSKY, L., & BURMAN, K. D. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-2-164 · Cited by 916
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
Friesema, E. C. H., Ganguly, S., Abdalla, A., Fox, J. E. M., Halestrap, A. P., & Visser, T. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300909200 · Cited by 725
Self-citationFriesema, E. C., Grueters, A., Biebermann, H., Krude, H., von Moers, A., Reeser, M., Barrett, T. G., Mancilla, E. E., Svensson, J., Kester, M. H., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17226-7 · Cited by 709
Self-citationHow does blood glucose control with insulin save lives in intensive care?
den Berghe, G. V. (2004) · Journal of Clinical Investigation · doi:10.1172/jci23506 · Cited by 558
Dangerous dogmas in medicine: the nonthyroidal illness syndrome
De Groot, L. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5364 · Cited by 505
Peeters, R. P., Wouters, P. J., Kaptein, E., van Toor, H., Visser, T. J., & Van den Berghe, G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-022013 · Cited by 452
Self-citationHennemann, G., Docter, R., Friesema, E. C. H., de Jong, M., Krenning, E. P., & Visser, T. J. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0435 · Cited by 394
Self-citationBrent, G. A., & Hershman, J. M. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-1-1 · Cited by 362
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“6 lg T3/kg daily compared to 48 patients that had not been treated with THs, provided clear evidence for tissue specific regulation of tissue T4 and T3 concentrations in critical illness (645).”
Self-citationPathophysiologic Response to Severe Burn Injury
Jeschke, M. G., Chinkes, D. L., Finnerty, C. C., Kulp, G. A., Suman-Vejas, O. E., Norbury, W. B., Branski, L. K., Gauglitz, G. G., Mlcak, R. P., & Herndon, D. N. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e3181856241 · Cited by 719
Thyroid function in critically ill patients
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Type 1 iodothyronine deiodinase in human physiology and disease
Maia, A. L., Goemann, I. M., Meyer, E. L. D. S., & Wajner, S. M. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0481 · Cited by 229
The Nonthyroidal Illness Syndrome
Adler, S. M., & Wartofsky, L. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.04.007 · Cited by 218
Metadata
- Authors
- Peeters, R. P., van der Geyten, S., Wouters, P. J., Darras, V. M., van Toor, H., Kaptein, E., Visser, T. J., & Van den Berghe, G.
- Affiliations
- Erasmus MC (NL)
- Laboratory of Comparative Endocrinology, Zoological Institute (S.v.d.G., V.M.D.), B-3000 Leuven, Belgium
- KU Leuven (BE)
- Department of Internal Medicine (R.P.P., H.v.T., E.K., T.J.V.), Erasmus University Medical Center, Rotterdam, The Netherlands;
- Department of Intensive Care Medicine (P.J.W., G.V.d.B.), Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-12-01
- Volume
- 90
- Issue
- 12
- Pages
- 6498-6507
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2119065033
- Cited by
- 145
- References
- 41
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 10 · 2013: 6 · 2012: 7
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Lirias (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- critical illness, thyroid hormones, triiodothyronine, reverse T3, thyroid hormone deiodinases, MCT8, liver, skeletal muscle, thyroid hormone replacement, ICU mortality, iodothyronines
- MeSH terms
- Aged, Female, Humans, Insulin, Iodide Peroxidase, Liver, Male, Middle Aged, Triiodothyronine, Triiodothyronine, Reverse, Randomized Controlled Trials as Topic, Critical Illness, Muscle, Skeletal, Monocarboxylic Acid Transporters, Symporters
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