Cited by 174Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryGrowth Hormone and Insulin-like Growth Factors

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Thyrotropin Suppression by Metformin

Vigersky, Robert A., Filmore-Nassar, Amy, Glass, Allan R.·2006·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2005-1210

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Abstract

Context: Drug-drug interactions are common but often are discovered only long after initial drug release. Metformin has been available in the United States for 9 yr and elsewhere for many years, but as of yet there are no reports that the drug modifies thyroid hormone economy. Objective: The objective of the study was to describe the clinical and biochemical findings of four patients with chronic hypothyroidism, previously euthyroid on fixed doses of l-T4 for several years, in whom the metformin was initiated. Design: This was a retrospective review. Setting: The study was conducted at a tertiary care military hospital providing care to active-duty soldiers, sailors, and marines, retirees of the armed forces, and their eligible dependents. Participants: Four patients with chronic hypothyroidism who were placed on metformin participated in the study. Intervention, Main Outcome Measure: Serum TSH, free T4, and free T3 levels were measured during metformin treatment. Results: Initiation of treatment with metformin (three for diabetes mellitus and one for nonalcoholic steatohepatitis) caused suppression of TSH to subnormal levels without clinical symptoms of hyperthyroidism in any patients. There was no change in free T4 or free T3 in patient 1. Conclusions: No other potential causes of TSH suppression, including medication changes or interference in the TSH assay, could be identified. The mechanism of the fall in serum TSH in these four patients is unclear at this time. Should these findings be confirmed in larger prospective studies, metformin’s ability to suppress TSH without causing clinical or chemical hyperthyroidism might render this drug a useful adjunct to the treatment of patients with thyroid cancer.

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Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157
Bioavailability of Albumin-Bound Testosterone†
Manni, A., Pardridge, W. M., Cefalu, W. T., NISULA, B. C., Bardin, C. W., Santner, S. J., & Santen, R. J. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-4-705 · Cited by 267
Effects of short‐term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo‐controlled trial
Wulffelé, M. G., Kooy, A., Lehert, P., Bets, D., Ogterop, J. C., van der Burg, B. B., Donker, A. J. M., & Stehouwer, C. D. A. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01213.x · Cited by 249
The Evolution of Gene Expression, Structure and Function of Transthyretin
Schreiber, G., & Richardson, S. J. (1997) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(96)00212-x · Cited by 188
Three-month treatment with metformin or dexfenfluramine does not modify the effects of diet on anthropometric and endocrine-metabolic parameters in abdominal obesity
Oleandri, S. E., Maccario, M., Rossetto, R., Massimo, P., Grottoli, S., Avogadri, E., Gauna, C., Ganzaroli, C., & Ghigo, E. (1999) · Journal of Endocrinological Investigation · doi:10.1007/bf03350893 · Cited by 30
The movement of thyroid hormones in the central nervous system.
Robbins, J., & Lakshmanan, M. C. (1992) · PubMed · Cited by 30
Lactic Acidosis With Therapeutic Metformin Blood Level in a Low-Risk Diabetic Patient
Al-Jebawi, A. F., LASSMAN, M. N., & Abourizk, N. N. (1998) · Diabetes Care · doi:10.2337/diacare.21.8.1364 · Cited by 29

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Authors: Vigersky, R. A., Filmore-Nassar, A., & Glass, A. R.
Affiliations: Walter Reed National Military Medical Center (US)
Corresponding author: Vigersky, Robert A.
ORCID: Vigersky, Robert A.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2006-01-01
Volume: 91
Issue: 1
Pages: 225-227
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2005-1210
OpenAlex: W1979756450
Cited by: 174
References: 12
Citations by year: 2026: 1 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 13 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 16 · 2016: 7 · 2015: 12 · 2014: 14 · 2013: 15 · 2012: 10
FWCI: 4.98
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Defense
U.S. Army
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: metformin, TSH suppression, thyroid-stimulating hormone, drug-drug interactions, thyroid hormone levels, free thyroxine, free T3, nonalcoholic steatohepatitis, diabetes mellitus
MeSH terms: Aged, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Drug Interactions, Female, Goiter, Graves Disease, Humans, Hypoglycemic Agents, Hypothyroidism, Liver Function Tests, Male, Metformin, Middle Aged, Retrospective Studies, Thyroid Function Tests, Thyroidectomy, Thyrotropin, Triiodothyronine, Hashimoto Disease

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Thyrotropin Suppression by Metformin

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