The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Metabolic Syndrome Is Associated with Reduced Central Serotonergic Responsivity in Healthy Community Volunteers
Abstract
CONTEXT: The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism. OBJECTIVE: The objective of this study was to test the hypothesis that low central serotonergic activity is associated with the metabolic syndrome. DESIGN, SETTING, PARTICIPANTS: This was a cross-sectional study of 345 healthy community volunteers, aged 30-55 yr, not taking medications for hypertension, lipid disorders, or diabetes. OUTCOME MEASURES: Central serotonergic responsivity was assessed with the iv citalopram challenge test. The serum prolactin area under the curve (AUC) over 150 min was calculated, and all analyses were adjusted for age, sex, plasma citalopram concentration, and baseline prolactin. The metabolic syndrome was defined according to the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) criteria. Insulin resistance was estimated by homeostasis model assessment. RESULTS: Compared with other individuals, persons meeting either NCEP or IDF criteria for the metabolic syndrome had lower mean prolactin responses (P < 0.05 for both). Using logistic regression, a decrease in prolactin AUC of 1 sd (-13.6 ng/ml.h) more than doubled the odds of having the metabolic syndrome (NCEP criteria: odds ratio, 2.38; 95% confidence interval, 1.14-4.97; P = 0.02; IDF criteria: odds ratio, 2.80; 95% confidence interval, 1.48-5.30; P = 0.002). Finally, the prolactin AUC was negatively associated with insulin resistance (beta = -0.03, P = 0.02). CONCLUSIONS: Corroborating previous evidence, the metabolic syndrome was associated with diminished brain serotonergic activity as reflected in a comparative blunting of the prolactin response to a selective serotonergic challenge. This association may have implications for the etiology, prevention, and treatment of the metabolic syndrome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A biologically plausible shared antecedent is diminished central serotonergic function. Reduced serotonin availability has been linked to increased appetite and weight gain, central adiposity, impaired glucose tolerance, and insulin resistance, alongside depressed mood (88).”
From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [88]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Glucose Metabolism in Patients With Schizophrenia Treated With Atypical Antipsychotic Agents
Henderson, D. C., Cagliero, E., Copeland, P. M., Borba, C. P. C., Evins, A. E., Hayden, D. L., Weber, M., Anderson, E. J., Allison, D. B., Daley, T. B., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.1.19 · Cited by 320
Quattrone, A., Tedeschi, G., Aguglia, U., Scopacasa, F., Renzo, G. F. D., & Annunziato, L. (1983) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1983.tb02202.x · Cited by 165
Neuroendocrine probes of serotonergic function: A critical review
Yatham, L. N., & Steiner, M. S. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90696-z · Cited by 164
Goodnick, P. J. (2001) · Annals of Clinical Psychiatry · doi:10.1023/a:1009012815127 · Cited by 146
Kreier, F., Yılmaz, A., Kalsbeek, A., Romijn, J. A., Sauerwein, H. P., Fliers, E., & Buijs, R. M. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2652 · Cited by 129
Goodnick, P. J. (2001) · Annals of Clinical Psychiatry · doi:10.3109/10401230109147127 · Cited by 124
Muldoon, M. F., Mackey, R. H., Williams, K. V., Korytkowski, M. T., Flory, J. D., & Manuck, S. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031295 · Cited by 123
Breum, L., Christensen, U. B., Bak, J. F., Jacobsen, S., & Astrup, A. V. (1995) · Metabolism · doi:10.1016/0026-0495(95)90077-2 · Cited by 86
White-Coat Hypertension and Carotid Artery Atherosclerosis
Muldoon, M. F., Nazzaro, P., Sutton‐Tyrrell, K., & Manuck, S. B. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.10.1507 · Cited by 81
Renzo, G. D., Amoroso, S., Taglialatela, M., Canzoniero, L. M. T., Basile, V., Fatatis, A., & Annunziato, L. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90302-6 · Cited by 78
The relationship between central serotonergic activity and insulin sensitivity in healthy volunteers
Horáček, J., Kuzmiaková, M., Höschl, C., Anděl, M., & Bahbonh, R. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00026-8 · Cited by 56
Padayatti, P. S., & Paulose, C. S. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00261-1 · Cited by 34
Lotrich, F. E., Bies, R. R., Muldoon, M. F., Manuck, S. B., Smith, G. S., & Pollock, B. G. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2006-4 · Cited by 32
Clinical studies with d-fenfluramine
Guy-grand, B. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.1.173s · Cited by 26
Knockout Corner: Neurobehavioural consequences of a serotonin 5-HT2C receptor gene mutation
Heisler, L. K., & Tecott, L. H. (1999) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145799001327 · Cited by 25
Kreier, F., Kalsbeek, A., Ruiter, M., Yılmaz, A., Romijn, J. A., Sauerwein, H. P., Fliers, E., & Buijs, R. M. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.092 · Cited by 23
A comparison of d,l-fenfluramine and citalopram challenges in healthy adults
Flory, J. D., Manuck, S. B., Perel, J. M., & Muldoon, M. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1763-9 · Cited by 20
Flagged first, then by citations
Research works printed but not linked: 1
- Sanders-Bush, 2001, 5-Hydroxytryptamine (serotonin) receptor agonists and antagonists, In: Hardman JG, Limbird LE, eds. Goodman, Gilman’s the pharmacological basis of therapeutics. New York: McGraw-Hill;, 269
Cited by
Sorted by citations
Self-reported sleep quality is associated with the metabolic syndrome
Jennings, J. R., Muldoon, M. F., Hall, M., Buysse, D. J., & Manuck, S. B. (2007) · Sleep · doi:10.1093/sleep/30.2.219 · Cited by 344
Depressive Symptoms and Stressful Life Events Predict Metabolic Syndrome Among Middle-Aged Women
Räikkönen, K., Matthews, K. A., & Kuller, L. H. (2007) · Diabetes Care · doi:10.2337/dc06-1857 · Cited by 279
Endocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221
Goldbacher, E. M., & Matthews, K. A. (2007) · Annals of Behavioral Medicine · doi:10.1007/bf02874549 · Cited by 196
The hormonal control of ejaculation
Corona, G., Jannini, E. A., Vignozzi, L., Rastrelli, G., & Maggi, M. (2012) · Nature Reviews Urology · doi:10.1038/nrurol.2012.147 · Cited by 189
Metadata
- Authors
- Muldoon, M. F., Mackey, R. H., Korytkowski, M. T., Flory, J. D., Pollock, B. G., & Manuck, S. B.
- Affiliations
- University of Pittsburgh (US)
- Departments of Medicine and Epidemiology (R.H.M.), Pittsburgh, Pennsylvania 15260
- Endocrinology (M.T.K.), Pittsburgh, Pennsylvania 15260
- Icahn School of Medicine at Mount Sinai (US)
- University of Toronto (CA)
- Corresponding author
- Muldoon, Matthew F.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-02-01
- Volume
- 91
- Issue
- 2
- Pages
- 718-721
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2003538836
- Cited by
- 102
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 10 · 2012: 12
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- National Institutes of Health
- National Heart, Lung, and Blood Institute (P01HL040962)
- National Institute of Mental Health (K24MH065416)
- National Center for Research Resources (M01RR000056)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- metabolic syndrome, prolactin, insulin resistance, hypothalamic-pituitary regulation, healthy adults
- MeSH terms
- Adult, Brain, Cross-Sectional Studies, Female, Humans, Insulin Resistance, Male, Middle Aged, Prolactin, Serotonin, Citalopram, Logistic Models, Selective Serotonin Reuptake Inhibitors, Area Under Curve, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
