Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome
Open accessAbstract
Context: Stress-mediated hypothalamic-pituitary-adrenal axis activation, regulated by arginine vasopressin (AVP), may have a role in the pathophysiology of metabolic syndrome (MetSyn). Objective: The objective of the study was to investigate whether plasma C-terminal provasopressin fragment (copeptin), a surrogate for circulating AVP, was associated with measures of insulin resistance and presence of MetSyn. Design, Setting, and Participants: This was a multicenter, community-based study, investigating novel biomarkers for vascular disease. Participants included 1293 African-Americans (AA) (64 ± 9 yr) and 1197 non-Hispanic whites (NHW) (59 ± 10 yr) belonging to hypertensive sibships. Main Outcome Measures: Plasma copeptin levels were measured by an immunoluminometric assay. MetSyn was defined per Adult Treatment Panel III criteria. Generalized estimating equations were used to assess whether plasma copeptin was associated with measures of insulin resistance and MetSyn. Results: The prevalence of MetSyn was 50% in AA and 49% in NHW. In each group, after adjustment for age and sex, plasma copeptin levels significantly correlated with body mass index, fasting plasma glucose and insulin, homeostasis model assessment of insulin resistance, triglycerides, and (inversely) high-density lipoprotein cholesterol (P < 0.05 for each variable). In multivariable logistic regression models that adjusted for age, sex, smoking, statin use, serum creatinine, education, physical activity, and diuretic use, plasma copeptin levels in the highest quartile were associated with an increased odds ratio of having MetSyn compared with bottom quartile: odds ratio (95% confidence interval) in AA, 2.07 (1.45–2.95); in NHW, 1.74 (1.21–2.5). Conclusions: Our findings indicate a novel cross-sectional association between plasma copeptin and measures of insulin resistance and MetSyn.
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Recent findings show a cross-sectional association between plasma vasopressin and insulin resistance.
“Interestingly, recent findings also indicate a cross-sectional association between plasma vasopressin and insulin resistance.3”
From Plasma Copeptin and the Risk of Diabetes Mellitus (2010) · cites this paper as [3]
In humans, high plasma copeptin is associated with insulin resistance, metabolic syndrome and obesity.
“Plasma copeptin, a stable surrogate marker for VP derived from the same preprohormone [16], has been shown to be associated with insulin resistance, metabolic syndrome and obesity [17].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [17]
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A comprehensive review on metabolic syndrome
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RetractedPlasma Copeptin and the Risk of Diabetes Mellitus
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Metabolic Syndrome: An Emerging Threat
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- Authors
- Saleem, U., Khaleghi, M., Morgenthaler, N. G., Bergmann, A., Struck, J., Mosley, T. H., & Kullo, I. J.
- Affiliations
- Mayo Clinic (US)
- Research Department of BRAHMS AG (N.G.M., A.B., J.S.), Biotechnology Centre, D-16761 Hennigsdorf/Berlin, Germany
- University of Mississippi Medical Center (US)
- Corresponding author
- Kullo, Iftikhar J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2009-07-01
- Volume
- 94
- Issue
- 7
- Pages
- 2558-2564
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC2708945
- OpenAlex
- W2149231688
- Semantic Scholar
- c330851b398d5b1ea932675c7bf6f421e0d65c32
- Cited by
- 161
- References
- 43
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 18 · 2019: 13 · 2018: 14 · 2017: 10 · 2016: 19 · 2015: 14 · 2014: 6 · 2013: 7 · 2012: 6
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 81331, U01HL081331)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- copeptin, vasopressin, insulin resistance, metabolic syndrome, hypothalamic-pituitary-adrenal axis, stress, African Americans, non-Hispanic whites, biomarkers, vascular disease, body mass index, lipid profile
- MeSH terms
- Aged, Black or African American, Cross-Sectional Studies, Female, Glycopeptides, Humans, Insulin Resistance, Male, Middle Aged, Models, Biological, Biomarkers, Metabolic Syndrome, White People
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