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Relationship of Adolescent Polycystic Ovary Syndrome to Parental Metabolic Syndrome
Abstract
CONTEXT: We determined the relationship of metabolic syndrome (MBS) to polycystic ovary syndrome (PCOS). OBJECTIVE: We tested the hypothesis that parental MBS is related to the PCOS phenotype in their offspring. DESIGN/SETTING: We phenotyped for MBS and PCOS in our General Clinical Research Center. PATIENTS: Girls with PCOS, 12-19 yr old (n = 36, including one pair of siblings), and their parents (35 mothers, 19 fathers) were recruited from the Pediatric Endocrinology Clinic. Healthy girls, 12-19 yr old (n = 21), were recruited as a reference population. INTERVENTIONS: We measured anthropometrics, blood pressure, fasting lipids and androgens, oral glucose tolerance, and ultrasonographically determined polycystic ovary status. MAIN OUTCOME MEASURES: MBS in parents, and PCOS features in mothers, were related to the presence of PCOS features in probands. RESULTS: Fathers had strikingly high prevalence of excess adiposity (94% were obese or overweight) and MBS (79%). Premenopausal mothers more commonly had MBS (36%) than features of PCOS (< or =22%). Polycystic ovaries in proband offspring of premenopausal mothers were associated with maternal polycystic ovaries only in a minority of cases. Proband polycystic ovary status was completely concordant to fathers' MBS status (P = 0.008), but not their own or their mothers' MBS status, in families whose premenopausal mothers lacked polycystic ovaries. Proband prevalence of MBS was 27.8%, 3-fold greater than expected for obesity status. CONCLUSION: Familial factors related to paternal MBS seem to be fundamental to the pathogenesis of PCOS.
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“Fasting insulin and 24-hour insulin concentrations as well as stimulated insulin responses to intravenous glucose are elevated in adolescent girls at risk for PCOS even after adjusting for BMI [113]”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [113]
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Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Practical Statistics for Medical Research
Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,317
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982
Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866
Practical Statistics for Medical Research.
Bartko, J. J., & Altman, D. G. (1992) · Journal of the American Statistical Association · doi:10.2307/2290246 · Cited by 4,834
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.
Hedley, A. A., Ogden, C., Johnson, C. L., Carroll, M., Curtin, L. R., & Flegal, K. (2004) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.291.23.2847 · Cited by 4,670
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715
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Items 101–118 of 118
Dere, K. A. L., Koffi, K. G., Niamke, A. G., Bita, D. V., Kahissié, M., & Tiahou, G. G. (2018) · International Journal of Medicine and Medical Sciences · doi:10.5897/ijmms2018.1348
Polyscystic Ovary Syndrome in Adolescents
Pabuçcu, R., Ergür, A. T., Durmus, A. B., & Pabuçcu, E. (2018) · Türk Üreme Tıbbı ve Cerrahisi Dergisi · doi:10.24074/tjrms.2018-59706
Zhi-ping, Z.-P., Hu, Ying, Y., Wang, Wenwei, Mao, M., Xiaowei, X., Zhang, Jie, J., Qiao, Q., et al. (2011) · 生殖与避孕：英文版
Jankowska, K. K., & Kaźmierczak-Dejewska, A. (2021) · Kwartalnik Naukowy Fides et Ratio · doi:10.34766/fetr.v47i3.922
What Is the Male Polycystic Ovary Syndrome Phenotype?
Welt, C. K. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab898
Clinical Evaluation of Patients with Suspected Reproductive Endocrine Disorders
Roberts, R. E., Franks, S., & Jayasena, C. N. (2022) · doi:10.1093/med/9780198870197.003.0153
(2006) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000242963.55738.b6
(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282c3a898
(2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f4f084
(2006) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2006.4.153
Bajpai, D., Shanmugham, D., Nagarajan, P., & Louis, L. R. P. (2023) · Donald School Journal of Ultrasound in Obstetrics & Gynecology · doi:10.5005/jp-journals-10009-1983
The Correlation Between Abnormal Uterine Bleeding in Early Menarche and PCOS Later in Adolescence
Deligeoroglou, E., & Karountzos, V. (2024) · ISGE series · doi:10.1007/978-3-031-55300-4_4
Wangange, S. M. P., Bosenge-Nguma, J.-D., O’yandjo, A. M., Lobo, A. M., & Mboloko, J. E. (2025) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2025.1512168
Gut microbiota and polycystic ovary syndrome: Pathogenesis and novel therapeutic approaches
Zhu, T., Sha, Y., Wang, Q., Yang, H., & Liu, T. (2026) · Microbiological Research · doi:10.1016/j.micres.2026.128643
Polycystic Ovary Syndrome in the Peripubertal Period
Witchel, S. F. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-499-5_13
Metadata
- Authors
- Leibel, N. I., Baumann, E. E., Kocherginsky, M., & Rosenfield, R. L.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Rosenfield, Robert L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-04
- Volume
- 91
- Issue
- 4
- Pages
- 1275-1283
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2129794022
- Cited by
- 118
- References
- 83
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 10 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 9 · 2013: 12 · 2012: 2
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- University of Chicago
- U.S. Public Health Service (U54-041859)
- Pfizer Pharmaceuticals
- National Center for Research Resources (RR-00055)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-39267, R01HD039267)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, metabolic syndrome, adolescent girls, parental influence, paternal obesity, family transmission, maternal metabolic syndrome, androgens, insulin resistance, hyperandrogenism
- MeSH terms
- Adolescent, Adult, Androgens, Anthropometry, Blood Pressure, Child, Fathers, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Parents, Phenotype, Polycystic Ovary Syndrome, Metabolic Syndrome, Dyslipidemias, Lipid Metabolism
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