CoChat
Sign Up
Cited by 298Hormonal and reproductive studiesNutrition and Health in AgingMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Testosterone Therapy Prevents Gain in Visceral Adipose Tissue and Loss of Skeletal Muscle in Nonobese Aging Men

Allan, C. A., Strauss, B. J. G., Burger, H. G., Forbes, E. A., McLachlan, R. I.·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-1291
Open this paper in CoChat — free account

Abstract

BACKGROUND: Trials of testosterone therapy in aging men have demonstrated increases in fat-free mass (FFM) and skeletal muscle and decreases in fat mass (FM) but have not reported the impact of baseline body composition. OBJECTIVE: The objective of the study was to determine the effect, in nonobese aging men with symptoms of androgen deficiency and low-normal serum testosterone levels, of testosterone therapy on total and regional body composition and hormonal and metabolic indices. METHODS: Sixty healthy but symptomatic, nonobese men aged 55 yr or older with total testosterone (TT) levels less than 15 nm were randomized to transdermal testosterone patches or placebo for 52 wk. Body composition, by dual-energy x-ray absorptiometry (FM, FFM, skeletal muscle) and magnetic resonance imaging (abdominal sc and visceral adipose tissue, thigh skeletal muscle, and intermuscular fat) and hormonal and metabolic parameters were measured at wk 0 and 52. RESULTS: Serum TT increased by 30% (P = 0.01), and LH decreased by 50% (P < 0.001). Relative to placebo, total body FFM (P = 0.03) and skeletal muscle (P = 0.008) were increased and thigh skeletal muscle loss was prevented (P = 0.045) with testosterone therapy and visceral fat accumulation decreased (P = 0.001) without change in total body or abdominal sc FM; change in visceral fat was correlated with change in TT levels (r2 = 0.36; P = 0.014). There was a trend to increasing total and low-density lipoprotein cholesterol with placebo. CONCLUSION: Testosterone therapy, relative to placebo, selectively lessened visceral fat accumulation without change in total body FM and increased total body FFM and total body and thigh skeletal muscle mass. Further studies are needed to determine the impact of these body compositional changes on markers of metabolic and cardiovascular risk.

Overview

Integrity signals

Registry

Crossref · 10.1210/jc.2007-1291

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 54 references

Cited by

Sorted by citations

See all 298

Related

Metadata

Authors
Allan, C. A., Strauss, B. J. G., Burger, H. G., Forbes, E. A., & McLachlan, R. I.
Affiliations
  • Monash University (AU)
  • Monash Medical Centre (AU)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-01
Volume
93
Issue
1
Pages
139-146
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-1291
OpenAlex
W2142786049
Cited by
298
References
54
Citations by year
2026: 9 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 16 · 2017: 10 · 2016: 12 · 2015: 10 · 2014: 19 · 2013: 22 · 2012: 18
FWCI
24.17
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
testosterone replacement therapy, androgen deficiency, older men, visceral adipose tissue, skeletal muscle mass, body composition, fat-free mass, LDL cholesterol, luteinizing hormone
MeSH terms
Administration, Cutaneous, Blood Glucose, Body Composition, Cholesterol, Double-Blind Method, Estradiol, Humans, Insulin, Insulin Resistance, Luteinizing Hormone, Magnetic Resonance Imaging, Male, Middle Aged, Testosterone, Triglycerides, Absorptiometry, Photon, Muscle, Skeletal, Hormone Replacement Therapy, Intra-Abdominal Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review