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Acylated Ghrelin Inhibits Spontaneous Luteinizing Hormone Pulsatility and Responsiveness to Naloxone But Not That to Gonadotropin-Releasing Hormone in Young Men: Evidence for a Central Inhibitory Action of Ghrelin on the Gonadal Axis
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CONTEXT: Recent evidence suggests that ghrelin exerts a negative modulation on the gonadal axis. Ghrelin was reported to suppress LH secretion in both animal and human models. Moreover, acylated ghrelin (AG) also decreases the LH responsiveness to GnRH in vitro. OBJECTIVE: The objective of the study was to evaluate the effects of AG infusion on spontaneous and stimulated gonadotropin secretion. DESIGN, PARTICIPANTS, AND INTERVENTION: In seven young healthy male volunteers (age mean +/- sem 26.4 +/- 2.6 yr), we evaluated LH and FSH levels every 15 min during: 1) iv isotonic saline infusion; 2) iv saline followed by AG; LH and FSH response to GnRH (100 microg iv as a bolus), 3) alone and 4) during AG infusion; LH and FSH response to naloxone (0.1 mg/kg iv as a slow bolus), 5) alone and 6) during AG infusion. RESULTS: Significant LH but not FSH pulses were recorded in all subjects under saline infusion. AG infusion inhibited LH levels [area under the curve((240-480)): 415.8 +/- 69.7 mIU/ml.min during AG vs. 744.6 +/- 120.0 mIU/ml.min during saline, P < 0.02] and abolished LH pulsatility. No change in FSH secretion was recorded. The LH and FSH responses to GnRH during saline were not affected by AG administration. However, AG inhibited the LH response to naloxone [area under the curve ((120-210)): 229.9 +/- 39.3 mIU/ml.min during AG vs. 401.1 +/- 44.6 mIU/ml.min during saline, P < 0.01]. FSH levels were not modified by naloxone alone or in combination with AG. CONCLUSIONS: AG inhibits both spontaneous LH pulsatility and the LH response to naloxone. Because AG does not affect the LH response to GnRH, these findings indicate that the ghrelin system mediates central inhibition of the gonadal axis.
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“Ghrelin has direct actions on the brain and the pituitary, where it has an inhibitory effect on gonadotropin pulsatility and decreases LH responsiveness to GnRH, as well as a stimulatory effect on prolactin secretion, probably involving direct action on somatomammotroph cells.111”
From Pubertal development and regulation (2016) · cites this paper as [111]
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Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion
Wren, A. M., Small, C. J., Ward, H. L., Murphy, K. G., Dakin, C. L., Taheri, S., Kennedy, A. R., Roberts, G. H., Morgan, D. G. A., Ghatei, M. A., et al. (2000) · Endocrinology · doi:10.1210/endo.141.11.7873 · Cited by 1,593
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187
Self-citationGuan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185
Ghrelin Strongly Stimulates Growth Hormone Release in Humans
Takaya, K., Ariyasu, H., Kanamoto, N., Iwakura, H., Yoshimoto, A., Harada, M., Mori, K., Komatsu, Y., Usui, T., Shimatsu, A., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7167 · Cited by 864 · cited 1×
“showing that acute boluses of AG, even at high doses, did not modify gonadotropin secretion in either rodents or humans (1, 29, 30) are likely to reflect the very limited time of observation and the acute administration.”
BackgroundLoucks, A. B., & Thuma, J. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020369 · Cited by 760
Deletion of Ghrelin Impairs neither Growth nor Appetite
Sun, Y., Ahmed, S., & Smith, R. G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7973-7981.2003 · Cited by 651
Toshinai, K., Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Kojima, M., Kangawa, K., & Matsukura, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4518 · Cited by 633
Ghrelin?a hormone with multiple functions
Korbonits, M. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.03.002 · Cited by 607
Hemodynamic and hormonal effects of human ghrelin in healthy volunteers
Nagaya, N., Kojima, M., Uematsu, M., Yamagishi, M., Hosoda, H., Oya, H., Hayashi, Y., & Kangawa, K. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.5.r1483 · Cited by 586
Bruni, J. F., Vugt, D. V., Marshall, S., & Meites, J. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90528-8 · Cited by 578
Veldhuis, J. D., Carlson, M. L., & Johnson, M. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7686 · Cited by 556
Peptidomimetic Regulation of Growth Hormone Secretion
Smith, R. G., der Ploeg, L. H. T. V., Howard, A. D., Feighner, S. D., Cheng, K., Hickey, G. J., Wyvratt, M. J., Fisher, M. H., Nargund, R. P., & Patchett, A. A. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0316 · Cited by 544
Endocrine consequences of long-term intrathecal administration of opioids
Abs, R., Verhelst, J., Maeyaert, J., Van Buyten, J.-P., Opsomer, F., Adriaensen, H., Verlooy, J., Van Havenbergh, T., Smet, M., & Van Acker, K. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6615 · Cited by 491
Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity
Muccioli, G., Tschöp, M. H., Papotti, M., Deghenghi, R., Heiman, M. L., & Ghigo, E. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01432-2 · Cited by 388
Self-citationNovel Expression and Functional Role of Ghrelin in Rat Testis
Tena‐Sempere, M., Barreiro, M. L., Gonzalez, L., Gaytán, F., Zhang, F., Caminos, J. E., Pinilla, L., Casanueva, F. F., Diéguez, C., & Aguilar, E. (2002) · Endocrinology · doi:10.1210/endo.143.2.8646 · Cited by 342
Endocrine Effects of Naloxone-Induced Opiate Receptor Blockade *
Morley, J. E., Baranetsky, N. G., Wingert, T. D., Carlson, H. E., Hershman, J. M., Melmed, S. K., Levin, S. R., Jamison, K. R., Weitzman, R. E., Chang, R., et al. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-50-2-251 · Cited by 299
Increased plasma ghrelin level in lung cancer cachexia.
Shimizu, Y., Nagaya, N., Isobe, T., Imazu, M., Okumura, H., Hosoda, H., Kojima, M., Kangawa, K., & Kohno, N. (2003) · PubMed · Cited by 284
Tannenbaum, G. S., Epelbaum, J., & Bowers, C. Y. (2003) · Endocrinology · doi:10.1210/en.2002-220852 · Cited by 248
Furuta, M., Funabashi, T., & Kimura, F. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5854 · Cited by 237
Esler, W. P., Rudolph, J., Claus, T. H., Tang, W., Barucci, N., Brown, S.-E., Bullock, W., Daly, M., DeCarr, L. B., Li, Y., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0239 · Cited by 236
Fernández-Fernández, R., Tena‐Sempere, M., Navarro, V. M., Barreiro, M. L., Castellano, J. M., Aguilar, E., & Pinilla, L. (2005) · Neuroendocrinology · doi:10.1159/000092753 · Cited by 217
Biological, Physiological, and Pharmacological Aspects of Ghrelin
Hosoda, H., Kojima, M., & Kangawa, K. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj06002x · Cited by 203
Effects of Undernutrition on Reproductive Function in the Human*
Warren, M. P. (1983) · Endocrine Reviews · doi:10.1210/edrv-4-4-363 · Cited by 186
Ghrelin effects on gonadotropin secretion in male and female rats
Fernández-Fernández, R., Tena‐Sempere, M., Aguilar, E., & Pinilla, L. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.03.003 · Cited by 173
Vulliémoz, N. R., Xiao, E., Xia‐Zhang, L., Germond, M., Rivier, J., & Ferin, M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1244 · Cited by 166
Ghrelin and reproduction: a novel signal linking energy status and fertility?
Barreiro, M. L., & Tena‐Sempere, M. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.07.015 · Cited by 166
THE OPIOID CONTROL OF LH AND FSH RELEASE: EFFECTS OF A MET‐ENKEPHALIN ANALOGUE AND NALOXONE
Grossman, A. B., MOULT, P. J. A., Gaillard, R.-C., Delitala, G., Toff, W. D., REES, L. H., & BESSER, G. M. (1981) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1981.tb00363.x · Cited by 163
Ghrelin Inhibits the Development of Mouse Preimplantation Embryos in Vitro
Kawamura, K., Sato, N., Fukuda, J., Kodama, H., Kumagai, J., Tanikawa, H., Nakamura, A., Honda, Y., Sato, T., & Tanaka, T. (2003) · Endocrinology · doi:10.1210/en.2003-0033 · Cited by 160
Iqbal, J., Kurose, Y., Canny, B. J., & Clarke, I. J. (2005) · Endocrinology · doi:10.1210/en.2005-1048 · Cited by 155
Tamura, T., Irahara, M., Tezuka, M., Kiyokawa, M., & Aono, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1573 · Cited by 152
Effects of Chronic Hyperghrelinemia on Puberty Onset and Pregnancy Outcome in the Rat
Fernández-Fernández, R., Navarro, V. M., Barreiro, M. L., Vigo, E., Tovar, S. A., Sirotkin, A. V., Casanueva, F. F., Aguilar, E., Diéguez, C., Pinilla, L., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1622 · Cited by 148
Endocrine aspects of acute and prolonged critical illness
Vanhorebeek, I., Langouche, L., & Van den Berghe, G. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0071 · Cited by 141
Ghrelin Suppresses Secretion of Luteinizing Hormone in Humans
Kluge, M., SCHÜSSLER, P., Uhr, M., Yassouridis, A., & Steiger, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0593 · Cited by 139
Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency
Daniell, H. W., Lentz, R., & Mazer, N. A. (2006) · The Journal of Pain · doi:10.1016/j.jpain.2005.10.009 · Cited by 135
Broglio, F., Gianotti, L., Destefanis, S., Fassino, S., Daga, G. A., Mondelli, V., Lanfranco, F., Gottero, C., Gauna, C., Hofland, L. J., et al. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02011.x · Cited by 128
Self-citationKaynard, A. H., Pau, K. ‐. F., Hess, D. L., & Spies, H. G. (1990) · Endocrinology · doi:10.1210/endo-127-5-2437 · Cited by 123
I’Anson, H., Foster, D. L., Foxcroft, G. R., & Booth, P. J. (1991) · PubMed · Cited by 116
Heterogeneity of Ghrelin/Growth Hormone Secretagogue Receptors
Muccioli, G., Baragli, A., Granata, R., Papotti, M., & Ghigo, E. (2007) · Neuroendocrinology · doi:10.1159/000105141 · Cited by 104
Self-citationCentral and Peripheral Roles of Ghrelin on Glucose Homeostasis
Sun, Y., Asnicar, M., & Smith, R. G. (2007) · Neuroendocrinology · doi:10.1159/000109094 · Cited by 102
Opiate receptors and anterior pituitary hormone secretion in man. Effect of naloxone infusion
Delitala, G., Devilla, L., & Arata, L. (1981) · European Journal of Endocrinology · doi:10.1530/acta.0.0970150 · Cited by 92
Vulliémoz, N. R., Xiao, E., Xia‐Zhang, L., Wardlaw, S. L., & Ferin, M. (2004) · Endocrinology · doi:10.1210/en.2004-1093 · Cited by 80
Exploring the role of ghrelin as novel regulator of gonadal function
Tena‐Sempere, M. (2005) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2005.02.001 · Cited by 69
Vulliémoz, N. R., Xiao, E., Xia‐Zhang, L., Rivier, J., & Ferin, M. (2007) · Endocrinology · doi:10.1210/en.2007-1350 · Cited by 67
Two Subgroups of Gonadotropin Releasing Hormone Neurons Control Gonadotropin Secretion in Rats
Kimura, F., & Funabashi, T. (1998) · Physiology · doi:10.1152/physiologyonline.1998.13.5.225 · Cited by 52
Energy availability and infertility
Loucks, A. B. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f1cb6a · Cited by 46
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Metadata
- Authors
- Lanfranco, F., Bonelli, L., Baldi, M., Me, E., Broglio, F., & Ghigo, E.
- Affiliations
- University of Turin (IT)
- Corresponding author
- Ghigo, Ezio
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-09-01
- Volume
- 93
- Issue
- 9
- Pages
- 3633-3639
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2070539070
- Cited by
- 112
- References
- 48
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 12 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 9
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- acylated ghrelin, luteinizing hormone, LH pulsatility, gonadotropin-releasing hormone, naloxone, follicle-stimulating hormone, gonadal axis, young men
- MeSH terms
- Acylation, Adult, Algorithms, Follicle Stimulating Hormone, Gonads, Humans, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Naloxone, Pulsatile Flow, Time Factors, Ghrelin
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