Cited by 112Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityGrowth Hormone and Insulin-like Growth Factors

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Acylated Ghrelin Inhibits Spontaneous Luteinizing Hormone Pulsatility and Responsiveness to Naloxone But Not That to Gonadotropin-Releasing Hormone in Young Men: Evidence for a Central Inhibitory Action of Ghrelin on the Gonadal Axis

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Lanfranco, Fabio, Bonelli, Lorenza, Baldi, Matteo, Me, Elisa, Broglio, Fabio, Ghigo, Ezio·2008·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2008-0049

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Abstract

CONTEXT: Recent evidence suggests that ghrelin exerts a negative modulation on the gonadal axis. Ghrelin was reported to suppress LH secretion in both animal and human models. Moreover, acylated ghrelin (AG) also decreases the LH responsiveness to GnRH in vitro. OBJECTIVE: The objective of the study was to evaluate the effects of AG infusion on spontaneous and stimulated gonadotropin secretion. DESIGN, PARTICIPANTS, AND INTERVENTION: In seven young healthy male volunteers (age mean +/- sem 26.4 +/- 2.6 yr), we evaluated LH and FSH levels every 15 min during: 1) iv isotonic saline infusion; 2) iv saline followed by AG; LH and FSH response to GnRH (100 microg iv as a bolus), 3) alone and 4) during AG infusion; LH and FSH response to naloxone (0.1 mg/kg iv as a slow bolus), 5) alone and 6) during AG infusion. RESULTS: Significant LH but not FSH pulses were recorded in all subjects under saline infusion. AG infusion inhibited LH levels [area under the curve((240-480)): 415.8 +/- 69.7 mIU/ml.min during AG vs. 744.6 +/- 120.0 mIU/ml.min during saline, P < 0.02] and abolished LH pulsatility. No change in FSH secretion was recorded. The LH and FSH responses to GnRH during saline were not affected by AG administration. However, AG inhibited the LH response to naloxone [area under the curve ((120-210)): 229.9 +/- 39.3 mIU/ml.min during AG vs. 401.1 +/- 44.6 mIU/ml.min during saline, P < 0.01]. FSH levels were not modified by naloxone alone or in combination with AG. CONCLUSIONS: AG inhibits both spontaneous LH pulsatility and the LH response to naloxone. Because AG does not affect the LH response to GnRH, these findings indicate that the ghrelin system mediates central inhibition of the gonadal axis.

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Authors: Lanfranco, F., Bonelli, L., Baldi, M., Me, E., Broglio, F., & Ghigo, E.
Affiliations: University of Turin (IT)
Corresponding author: Ghigo, Ezio
ORCID: Lanfranco, Fabio
Bonelli, Lorenza
Baldi, Matteo
Broglio, Fabio
Ghigo, Ezio
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2008-09-01
Volume: 93
Issue: 9
Pages: 3633-3639
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2008-0049
OpenAlex: W2070539070
Cited by: 112
References: 48
Citations by year: 2025: 1 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 12 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 9
FWCI: 10.84
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Zenodo (CERN European Organization for Nuclear Research)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: acylated ghrelin, luteinizing hormone, LH pulsatility, gonadotropin-releasing hormone, naloxone, follicle-stimulating hormone, gonadal axis, young men
MeSH terms: Acylation, Adult, Algorithms, Follicle Stimulating Hormone, Gonads, Humans, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Naloxone, Pulsatile Flow, Time Factors, Ghrelin

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Acylated Ghrelin Inhibits Spontaneous Luteinizing Hormone Pulsatility and Responsiveness to Naloxone But Not That to Gonadotropin-Releasing Hormone in Young Men: Evidence for a Central Inhibitory Action of Ghrelin on the Gonadal Axis

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