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A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism
Open accessAbstract
CONTEXT: Primary aldosteronism is a leading cause of secondary hypertension (HTN), but the mechanisms underlying the characteristic renin-independent secretion of aldosterone remain unknown in most patients. OBJECTIVES: We report a new familial form of aldosteronism in a father and two daughters. All were diagnosed with severe HTN refractory to medical treatment by age 7 yr. We performed a variety of clinical, biochemical, and genetic studies to attempt to clarify the underlying molecular defect. RESULTS: Biochemical studies revealed hyporeninemia, hyperaldosteronism, and very high levels of 18-oxocortisol and 18-hydroxycortisol, steroids that reflect oxidation by both steroid 17-alpha hydroxylase and aldosterone synthase. These enzymes are normally compartmentalized in the adrenal fasciculata and glomerulosa, respectively. Administration of dexamethasone failed to suppress either aldosterone or cortisol secretion; these findings distinguish this clinical syndrome from glucocorticoid-remediable aldosteronism, another autosomal dominant form of HTN, and suggest a global defect in the regulation of adrenal steroid production. Genetic studies excluded mutation at the aldosterone synthase locus, further distinguishing this disorder from glucocorticoid-remediable aldosteronism. Because of unrelenting HTN, all three subjects underwent bilateral adrenalectomy, which in each case corrected the HTN. Adrenal glands showed dramatic enlargement, with paired adrenal weights as high as 82 g. Histology revealed massive hyperplasia and cellular hypertrophy of a single cortical compartment that had features of adrenal fasciculata or a transitional zone, with an atrophic glomerulosa. CONCLUSION: These findings define a new inherited form of aldosteronism and suggest that identification of the underlying defect will provide insight into normal mechanisms regulating adrenal steroid biosynthesis.
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“These metabolites are often referred to as “hybrid steroids” as they require enzymatic machinery from both the glucocorticoid and mineralocorticoid pathways [[261], [262], [263]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [263]
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“As a consequence, urinary excretion of 18OHTHA and THAldo is low whereas corticosterone metabolites are high [Fig. 6 (50, 112–124)].”
From Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism (2019) · cites this paper as [113]
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“Serum and urinary 18-hydroxycortisol, 18-oxocortisol, and 18-oxo-THF excretion are highest in FHA type 1 (= GRA, see “Glucocorticoid-remediable aldosteronism” above) (124, 173) and FHA type 3 (germline KCNJ5 mutations) (113); they also tend to be higher in APA than in bilateral hyperaldosteronism, albeit with considerable overlap (115).”
From Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism (2019) · cites this paper as [113]
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Shimkets, R. A., Warnock, D. G., Bositis, C. M., Nelson-Williams, C. J., Hansson, J. H., Schambelan, M., Gill, J. R., Ulick, S., Milora, R. V., Findling, J. W., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90250-x · Cited by 1,256
Self-citationLifton, R. P., Dluhy, R. G., Powers, M., Rich, G. M., Cook, S., Ulick, S., & Lalouel, J.-M. (1992) · Nature · doi:10.1038/355262a0 · Cited by 1,158
Self-citationSteroidogenic Factor 1: an Essential Mediator of Endocrine Development
Parker, K. L. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.19 · Cited by 346
Lifton, R. P., Dluhy, R. G., Powers, M., Rich, G. M., Gutkin, M. C., Fallo, F., Gill, J. R., Feld, L. G., Ganguly, A., Laidlaw, J. C., et al. (1992) · Nature Genetics · doi:10.1038/ng0992-66 · Cited by 329
Self-citationStress hormone and male reproductive function
Hardy, M. P., Gao, H.-B., Dong, Q., Ge, R., Wang, Q., Chai, W. R., Feng, X., & Sottas, C. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-0006-2 · Cited by 298
PRIMARY ALDOSTERONISM, A NEW CLINICAL ENTITY
Conn, J. W., & LOUIS, L. H. (1956) · Annals of Internal Medicine · doi:10.7326/0003-4819-44-1-1 · Cited by 255
Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research
Shackleton, C. H. L. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90132-g · Cited by 247
Self-citationRich, G. M., Ulick, S., Cook, S., Wang, J. Z., Lifton, R. P., & Dluhy, R. G. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-10-813 · Cited by 183
Self-citationFAMILIAL HYPERALDOSTERONISM TYPE II: FIVE FAMILIES WITH A NEW VARIETY OF PRIMARY ALDOSTERONISM
Stowasser, M., Gordon, R. D., Tunny, T. J., Klemm, S. A., Finn, W. L., & Krek, A. L. (1992) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1992.tb00462.x · Cited by 154
Diagnosis of primary aldosteronism: from screening to subtype differentiation
Mulatero, P., Dluhy, R. G., Giacchetti, G., Boscaro, M., Veglio, F., & Stewart, P. M. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.02.007 · Cited by 143
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Metadata
- Authors
- Geller, D. S., Zhang, J., Wisgerhof, M. V., Shackleton, C., Kashgarian, M., & Lifton, R. P.
- Affiliations
- Howard Hughes Medical Institute (US)
- Henry Ford Hospital (US)
- Corresponding author
- Geller, David S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-08
- Volume
- 93
- Issue
- 8
- Pages
- 3117-3123
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC2515083
- OpenAlex
- W2154788287
- Cited by
- 296
- References
- 24
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 25 · 2022: 16 · 2021: 11 · 2020: 17 · 2019: 21 · 2018: 19 · 2017: 20 · 2016: 26 · 2015: 22 · 2014: 18 · 2013: 20 · 2012: 25
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Yale University
- National Institutes of Health
- Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- familial hypertension, primary aldosteronism, secondary hypertension, 18-oxocortisol, 18-hydroxycortisol, aldosterone synthase, adrenal hyperplasia, adrenal cortex, glucocorticoid-remediable aldosteronism, bilateral adrenalectomy, adrenal steroidogenesis, autosomal dominant inheritance
- MeSH terms
- Adolescent, Adrenal Glands, Child, Child, Preschool, Female, Glucocorticoids, Humans, Hydrocortisone, Hyperaldosteronism, Hypertension, Male, Pedigree, Renin, Steroid 11-beta-Hydroxylase, Cytochrome P-450 CYP11B2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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