Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research

New developments in biochemical mass spectrometry: electrospray ionization.

Smith, R. D., Loo, J., Edmonds, C. G., Barinaga, C., & Udseth, H. (1990) · Analytical Chemistry · doi:10.1021/ac00208a002 · Cited by 975 · see citing works

MINERALOCORTICOID ACTIVITY OF LIQUORICE: 11-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY COMES OF AGE

Stewart, P., Valentino, R., Wallace, A. M., Burt, D., Shackleton, C., & Edwards, C. R. W. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91014-2 · Cited by 798 · see citing works

A Syndrome of Apparent Mineralocorticoid Excess Associated with Defects in the Peripheral Metabolism of Cortisol*

Ulick, S., Kodama, T., GUNCZIER, P., Zanconato, G., Ramirez, L. C., Rauh, W., Rösler, A., Bradlow, H. L., & New, M. I. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-5-757 · Cited by 494 · see citing works

Licorice-Induced Hypermineralocorticoidism

Farese, R. V., Biglieri, E. G., Shackleton, C. H. L., Irony, I., & Gomez-Fontes, R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110243251706 · Cited by 293 · see citing works

A LIQUORICE EXTRACT WITH DEOXYCORTONE-LIKE ACTION

Molhuysen, J. A., Gerbrandy, J., Vries, L. A. D., et al. (1950) · The Lancet · doi:10.1016/s0140-6736(50)91341-9 · Cited by 179 · see citing works

Correctable Subsets of Primary Aldosteronism Primary Adrenal Hyperplasia and Renin Responsive Adenoma

Irony, I., Kater, C. E., Biglieri, E. G., & Shackleton, C. H. L. (1990) · American Journal of Hypertension · doi:10.1093/ajh/3.7.576 · Cited by 161 · see citing works

Identification of the Steroids in Neonatal Plasma that Interfere with 17 Alpha-Hydroxyprogesterone Radioimmunoassays

Wong, T., Shackleton, C. H., Covey, T. R., & Ellis, G. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.9.1830 · Cited by 159 · see citing works

Isolation and identification of 18-hydroxycortisol from the urine of patients with primary aldosteronism.

Chu, M. D., & Ulick, S. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34909-3 · Cited by 121 · see citing works

The Influence of Glycyrrhetinic Acid on Plasma Cortisol and Cortisone in Healthy Young Volunteers

MacKenzie, M. A., Hoefnagels, W. H. L., Jansen, R. W. M. M., Benraad, T. J., & KLOPPENBORG, P. W. C. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-6-1637 · Cited by 121 · see citing works

COCAINE AND MORPHINE WITHDRAWAL

Clarke, M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90554-0 · Cited by 107 · see citing works

Determination of boldenone sulfoconjugate and related steroid sulfates in equine urine by high-performance liquid chromatography/tandem mass spectrometry

Weidolf, L. O. G., Lee, E. D., & Henion, J. D. (1988) · Journal of Mass Spectrometry · doi:10.1002/bms.1200150508 · Cited by 100 · see citing works

Mass spectrometry of biological materials

Sellier, N. M. (1990) · Biochimie · doi:10.1016/0300-9084(90)90102-m · Cited by 92 · see citing works

Identifiction of 3β, 17β-dihydroxyandrost-5-ene, 3β,20α-dihydroxypregn-5-ene and epiandrosterone in human peripheral blood

Sjövall, J., & Vihko, R. (1966) · Steroids · doi:10.1016/0039-128x(66)90072-9 · Cited by 87 · see citing works

Dexamethasone-Suppressible Hyperaldosteronism

New, M. I., Siegal, E. J., & Peterson, R. E. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-1-93 · Cited by 84 · see citing works

Pathogenesis of the Type 2 Variant of the Syndrome of Apparent Mineralocorticoid Excess*

Ulick, S., Tedde, R., & Mantero, F. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-1-200 · Cited by 82 · see citing works

Gas Phase Chromatography of Steroids.

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A new defect in the peripheral conversion of cortisone to cortisol

Phillipou, G., & Higgins, B. (1985) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(85)90451-0 · Cited by 79 · see citing works

Steroid profile for urine: reference values.

Weykamp, C. W., Penders, T. J., Schmidt, N., Borburgh, A. J., van de Calseyde, J. F., & Wolthers, B. J. (1989) · Clinical Chemistry · doi:10.1093/clinchem/35.12.2281 · Cited by 70 · see citing works

Mass Spectrometry: Application to Steroid and Peptide Research*

Shackleton, C. H. L., & Chai, W. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-3-441 · Cited by 66 · see citing works

Hypertension in a Four-Year-Old Child: Gas Chromatographic and Mass Spectrometric Evidence for Deficient Hepatic Metabolism of Steroids*

Shackleton, C. H. L., Honour, J. W., Dillon, M. J., CHANTLER, C., & Jones, R. W. A. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-50-4-786 · Cited by 66 · see citing works

Endocrine Hypertension*

MELBY, J. C. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-4-697 · Cited by 66 · see citing works

Dehydroepiandrosterone sulfate quantification in serum using high-performance liquid chromatography/ mass spectrometry and a deuterated internal standard: a technique suitable for routine use or as a reference method

Shackleton, C. H. L., Kletke, C., Wudy, S. A., & Pratt, J. H. (1990) · Steroids · doi:10.1016/0039-128x(90)90016-5 · Cited by 54 · see citing works

Thermospray HPLC/MS: A new mass spectrometric technique for the profiling of steroids

Liberato, D. J., Yergey, A. L., Esteban, N. V., Gómez-Sánchez, C. E., & Shackleton, C. H. L. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90295-0 · Cited by 49 · see citing works

Pathophysiology of Deoxycorticosterone-Secreting Adrenal Tumors*

Irony, I., Biglieri, E. G., Perloff, D. L., & Rubinoff, H. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-5-836 · Cited by 44 · see citing works

Gas Phase Analytical Methods for the Study of Steroid Hormones and their Metabolites

Horning, E. C. (1968) · Monographs on endocrinology · doi:10.1007/978-3-662-35229-8_1 · Cited by 41 · see citing works

Stable isotope dilution method using thermospray liquid chromatography/mass spectrometry for quantification of daily cortisol production in humans

Esteban, N. V., Yergey, A. L., Liberato, D. J., LOUGHLIN, T., & Loriaux, D. L. (1988) · Journal of Mass Spectrometry · doi:10.1002/bms.1200151105 · Cited by 39 · see citing works

Extraction and fractionation of bile acids and their conjugates using pre-packed microparticulate silica cartridges (sep-pak sil® and bond-elut® C18)

Street, J. M., Trafford, D. J. H., & Makin, H. L. J. (1985) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)84596-x · Cited by 36 · see citing works

Inborn errors of steroid biosynthesis: detection by a new mass-spectrometric method.

Shackleton, C. H. L. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.2.246 · Cited by 36 · see citing works

Corticosteroids and peptide hormones in hypertension

Mantero, F., & Vecsei, P. (1987) · Raven Press eBooks · Cited by 33 · see citing works

Analysis of intact steroid conjugates by secondary ion mass spectrometry (including FABMS) and by gas chromatography.

Shackleton, C. H. L., Mattox, V. R., & Honour, J. W. (1983) · PubMed · Cited by 29 · see citing works

Severe hypoaldosteronism due to corticosterone methyl oxidase type II deficiency in two boys: metabolic and gas chromatography-mass spectrometry studies

Hauffa, B. P., Sólyom, J., Gláz, E., Shackleton, C. H. L., Wambach, G. K., Vecsei, P., Stolecke, H., & Homoki, J. (1991) · European Journal of Pediatrics · doi:10.1007/bf01963554 · Cited by 28 · see citing works

Diagnosis of recessive X-linked ichthyosis: quantitative HPLC/mass spectrometric analysis of plasma for cholesterol sulfate.

Shackleton, C. H. L., & Reid, S. J. (1989) · Clinical Chemistry · doi:10.1093/clinchem/35.9.1906 · Cited by 28 · see citing works

Analysis of intact steroid conjugates by secondary ion mass spectrometry (including FABMS) and by gas chromatography

Shackleton, C. H. L., Mattox, V. R., & Honour, J. W. (1983) · Journal of Steroid Biochemistry · doi:10.1016/s0022-4731(83)80027-2 · Cited by 28 · see citing works

Measurement of 4 urinary C-18 oxygenated corticosteroids by stable isotope dilution mass fragmentography

Ulick, S., Chan, C. K., & Wang, J. Z. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90401-p · Cited by 23 · see citing works

Late-onset 21-hydroxylase deficiency: Reliable diagnosis by steroid analysis of random urine collections

Shackleton, C. H. L., IRIAS, J. J., McDonald, C., & Imperato‐McGinley, J. (1986) · Steroids · doi:10.1016/0039-128x(86)90007-3 · Cited by 10 · see citing works

11β-Hydroxysteroid dehydrogenase type 1: a tissue specific regulator of glucocorticoid response

Tomlinson, J. W., Walker, E. A., Bujalska, I. J., Draper, N., Lavery, G. G., Cooper, M. S., Hewison, M., & Stewart, P. M. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0031 · Cited by 969 · see citing works

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works

Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study

Arlt, W., Walker, E. A., Draper, N., Ivison, H. E., Ride, J. P., Hammer, F., Chalder, S. M., Borucka-Mankiewicz, M., Hauffa, B. P., Malunowicz, E. M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16503-3 · Cited by 345 · see citing works

A novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism

Geller, D. S., Zhang, J., Wisgerhof, M. V., Shackleton, C., Kashgarian, M., & Lifton, R. P. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0594 · Cited by 296 · see citing works

The art of measuring steroids

Wudy, S. A., Schuler, G., Sánchez-Guijo, A., & Hartmann, M. F. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.09.003 · Cited by 236 · see citing works

Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation

Lavery, G. G., Walker, E. A., Draper, N., Jeyasuria, P., Marcos, J., Shackleton, C. H. L., Parker, K. L., White, P. C., & Stewart, P. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512635200 · Cited by 207 · see citing works

Urinary markers of adrenarche: reference values in healthy subjects, aged 3–18 years

Remer, T., Boye, K. R., Hartmann, M. F., & Wudy, S. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1571 · Cited by 193 · see citing works

Increased activation of the alternative “backdoor” pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis

Kamrath, C., Hochberg, Z., Hartmann, M. F., Remer, T., & Wudy, S. A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1997 · Cited by 191 · see citing works

Automated, fast and sensitive quantification of 17α-hydroxy-progesterone, androstenedione and testosterone by tandem mass spectrometry with on-line extraction

Rauh, M., Gröschl, M., Rascher, W., & Dörr, H. G. (2006) · Steroids · doi:10.1016/j.steroids.2006.01.015 · Cited by 170 · see citing works

Beyond Adrenal and Ovarian Androgen Generation: Increased Peripheral 5α-Reductase Activity in Women with Polycystic Ovary Syndrome

Fassnacht, M., Schlenz, N., Schneider, S. B., Wudy, S. A., Allolio, B., & Arlt, W. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021875 · Cited by 158 · see citing works

Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism

Storbeck, K.-H., Schiffer, L., Baranowski, E. S., Chortis, V., Prete, A., Barnard, L., Gilligan, L. C., Taylor, A. E., Idkowiak, J., Arlt, W., et al. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00262 · Cited by 141 · see citing works

A Switch in Hepatic Cortisol Metabolism across the Spectrum of Non Alcoholic Fatty Liver Disease

Ahmed, A., Rabbitt, E., Brady, T., Brown, C., Guest, P., Bujalska, I. J., Doig, C., Newsome, P. N., Hubscher, S., Elias, E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029531 · Cited by 115 · see citing works

The diagnosis of congenital adrenal hyperplasia in the newborn by gas chromatography/mass spectrometry analysis of random urine specimens

Caulfield, M. P., Lynn, T., Gottschalk, M. E., Jones, K. L., Taylor, N. F., Malunowicz, E. M., Shackleton, C. H. L., Reitz, R. E., & Fisher, D. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.8.8712 · Cited by 120 · see citing works

Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype

Shackleton, C., Marcos, J., Arlt, W., & Hauffa, B. P. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30171 · Cited by 104 · see citing works

Sexual dimorphism in cortisol secretion starts after age 10 in healthy children: urinary cortisol metabolite excretion rates during growth

Wudy, S. A., Hartmann, M. F., & Remer, T. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00495.2006 · Cited by 101 · see citing works

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency

Lavery, G. G., Walker, E. A., Tiganescu, A., Ride, J. P., Shackleton, C. H. L., Tomlinson, J. W., Connell, J. M. C., Ray, D. W., Biason-Lauber, A., Malunowicz, E. M., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0743 · Cited by 95 · see citing works

Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents

Missaghian, E., Kempná, P., Dick, B., Hirsch, A., Alikhani-Koupaei, R., Jégou, B., Mullis, P. E., Frey, B. M., & Flück, C. E. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0353 · Cited by 91 · see citing works

Differential Inhibition of CYP17A1 and CYP21A2 Activities by the P450 Oxidoreductase Mutant A287P

Dhir, V., Ivison, H. E., Krone, N., Shackleton, C. H. L., Doherty, A. J., Stewart, P. M., & Arlt, W. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0066 · Cited by 78 · see citing works

Investigation of endogenous corticosteroids profiles in human urine based on liquid chromatography tandem mass spectrometry

Marcos, J., Renau, N., Casals, G., Segura, J., Ventura, R., & Pozo, O. J. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.12.030 · Cited by 76 · see citing works

GC/MS in recent years has defined the Normal and clinically disordered steroidome: will It Soon Be surpassed by LC/Tandem MS in this role?

Shackleton, C., Pozo, O. J., & Marcos, J. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00135 · Cited by 75 · see citing works

Quantitation of cortisol and related 3-oxo-4-ene steroids in urine using gas chromatography/mass spectrometry with stable isotope-labeled internal standards

Palermo, M., Gomez-Sanchez, C., Roitman, E., & Shackleton, C. H. L. (1996) · Steroids · doi:10.1016/s0039-128x(96)00118-9 · Cited by 70 · see citing works

Cortisone-reductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1

Lawson, A. J., Walker, E. A., Lavery, G. G., Bujalska, I. J., Hughes, B., Arlt, W., Stewart, P. M., & Ride, J. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014934108 · Cited by 61 · see citing works

Human Δ4-3-oxosteroid 5β-reductase (AKR1D1) deficiency and steroid metabolism

Palermo, M., Marazzi, M. G., Hughes, B. A., Stewart, P. M., Clayton, P. T., & Shackleton, C. H. L. (2008) · Steroids · doi:10.1016/j.steroids.2007.12.001 · Cited by 55 · see citing works

Neonatal urinary steroids in Smith-Lemli-Opitz syndrome associated with 7-dehydrocholesterol reductase deficiency

Shackleton, C. (1999) · Steroids · doi:10.1016/s0039-128x(99)00022-7 · Cited by 48 · see citing works

Genotypes at 11β-Hydroxysteroid Dehydrogenase Type 11B1 and Hexose-6-Phosphate Dehydrogenase Loci Are Not Risk Factors for Apparent Cortisone Reductase Deficiency in a Large Population-Based Sample

White, P. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0942 · Cited by 47 · see citing works

17-Hydroxylase/C17, 20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites

Shackleton, C. H. L., Neres, M. S., Hughes, B. A., Stewart, P. M., & Kater, C. E. (2008) · Steroids · doi:10.1016/j.steroids.2008.02.001 · Cited by 39 · see citing works

Reduced 11β-hydroxysteroid dehydrogenase type 1 activity in obese boys

Wiegand, S., Richardt, A., Remer, T., Wudy, S. A., Tomlinson, J. W., Hughes, B., Grüters, A., Stewart, P. M., Strasburger, C. J., & Quinkler, M. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0193 · Cited by 37 · see citing works

The Urinary Steroidome of Treated Children With Classic 21-Hydroxylase Deficiency

Kamrath, C., Wettstaedt, L., Boettcher, C., Hartmann, M. F., & Wudy, S. A. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.08.006 · Cited by 30 · see citing works

Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype

Crowley, R. K., Hughes, B., Gray, J., McCarthy, T., Hughes, S., Shackleton, C. H. L., Crabtree, N., Nightingale, P., Stewart, P. M., & Tomlinson, J. W. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0256 · Cited by 26 · see citing works

Corticosteroids in human blood: IX. Evidence for adrenal secretion of sulfate-conjugated cortisol, 11β,17α-dihydroxy-4-pregnene-3,20-dione-21-yl-sulfate

Kornel, L., Patel, S. K., Ezzeraimi, E., & Shackleton, C. H. L. (1995) · Steroids · doi:10.1016/0039-128x(95)00141-c · Cited by 3 · see citing works

Electrospray mass spectrometry of the self-assembly of a capped polymetallic complex

Leize, E., Dorsselaer, A. V., Krämer, R., et al. (1993) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39930000990 · Cited by 89 · see citing works

Determination of additives, contaminants and byproducts in insulating liquids with desorption electrospray mass spectrometry

Kapila, S. (2015) · Journal of Chromatography & Separation Techniques

Studies on the process of electrospray and applications of electrospray mass spectrometry.

Ke, F. (1998) · doi:10.22215/etd/1998-04052

FACILE DETECTION OF ORGANOMETALLIC DERIVATIVES OF PEPTIDES USING ELECTROSPRAY MASS SPECTROMETRY

Bennett, K. L., Carver, J. A., David, D. M., et al. (1995) · Journal of Coordination Chemistry · doi:10.1080/00958979508024323 · Cited by 5 · see citing works

A severe peak tailing of phosphate compounds caused by interaction with stainless steel used for liquid chromatography and electrospray mass spectrometry

Wakamatsu, A., Morimoto, K., Shimizu, M., et al. (2005) · Journal of Separation Science · doi:10.1002/jssc.200400027 · Cited by 88 · see citing works