Shackleton, Cedric H. L.

Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors

Arlt, W., Biehl, M., Taylor, A. E., Hahner, S., Libé, R., Hughes, B. A., Schneider, P., Smith, D. J., Stiekema, H., Krone, N., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism

Adrenal and Paraganglionic TumorsMetabolomics and Mass Spectrometry Studies

Cited by 458

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology

Metabolomics and Mass Spectrometry StudiesAdrenal Hormones and Disorders

Cited by 450

Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)

Krone, N., Hughes, B. A., Lavery, G. G., Stewart, P. M., Arlt, W., & Shackleton, C. H. L. (2010) · The Journal of Steroid Biochemistry and Molecular Biology

Metabolism and Genetic DisordersMetabolomics and Mass Spectrometry Studies

Cited by 434

Cortisol Metabolism in Human Obesity: Impaired Cortisone→Cortisol Conversion in Subjects with Central Adiposity1

Stewart, P. M., Boulton, A., Kumar, S., Clark, P. M. S., & Shackleton, C. H. L. (1999) · The Journal of Clinical Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdrenal Hormones and Disorders

Cited by 398

Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study

Arlt, W., Walker, E. A., Draper, N., Ivison, H. E., Ride, J. P., Hammer, F., Chalder, S. M., Borucka-Mankiewicz, M., Hauffa, B. P., Malunowicz, E. M., et al. (2004) · The Lancet

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 345

A novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism

Geller, D. S., Zhang, J., Wisgerhof, M. V., Shackleton, C., Kashgarian, M., & Lifton, R. P. (2008) · The Journal of Clinical Endocrinology & Metabolism

Hormonal Regulation and HypertensionRenin-Angiotensin System Studies

Cited by 296

Profiling steroid hormones and urinary steroids

Shackleton, C. H. L. (1986) · Journal of Chromatography B Biomedical Sciences and Applications

Adrenal Hormones and DisordersAnalytical Chemistry and Chromatography

Cited by 291

Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

Draper, N., Walker, E. A., Bujalska, I. J., Tomlinson, J. W., Chalder, S. M., Arlt, W., Lavery, G. G., Bedendo, O., Ray, D. W., Laing, I., et al. (2003) · Nature Genetics

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 285

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism

Arlt, W., Lang, K., Sitch, A. J., Dietz, A. S., Rhayem, Y., Bancos, I., Feuchtinger, A., Chortis, V., Gilligan, L. C., Ludwig, P., et al. (2017) · JCI Insight

Hormonal Regulation and HypertensionAdrenal and Paraganglionic Tumors

Cited by 281

Urinary free cortisone and the assessment of 11β‐hydroxysteroid dehydrogenase activity in man

Palermo, M., Shackleton, C. H. L., Mantero, F., & Stewart, P. M. (1996) · Clinical Endocrinology

Hormonal Regulation and HypertensionAdrenal Hormones and Disorders

Cited by 276

Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research

Shackleton, C. H. L. (1993) · The Journal of Steroid Biochemistry and Molecular Biology

Mass Spectrometry Techniques and ApplicationsHormonal Regulation and Hypertension

Cited by 247

Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation

Lavery, G. G., Walker, E. A., Draper, N., Jeyasuria, P., Marcos, J., Shackleton, C. H. L., Parker, K. L., White, P. C., & Stewart, P. M. (2006) · Journal of Biological Chemistry

Hormonal Regulation and HypertensionAdrenal Hormones and Disorders

Cited by 207

5 α-reductase activity in polycystic ovary syndrome

Stewart, P. M., Edwards, C. R. W., Shackleton, C. H. L., & Beastall, G. H. (1990) · The Lancet

Ovarian function and disordersAdrenal Hormones and Disorders

Cited by 189

Genotype-Phenotype Analysis in Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency

Krone, N., Reisch, N., Idkowiak, J., Dhir, V., Ivison, H. E., Hughes, B. A., Rose, I. T., O'Neil, D. M., Vijzelaar, R., Smith, M. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 163

Identification of the Steroids in Neonatal Plasma that Interfere with 17 Alpha-Hydroxyprogesterone Radioimmunoassays

Wong, T., Shackleton, C. H., Covey, T. R., & Ellis, G. (1992) · Clinical Chemistry

Sexual Differentiation and DisordersClinical Laboratory Practices and Quality Control

Cited by 159

Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement

Chortis, V., Taylor, A. E., Schneider, P., Tomlinson, J. W., Hughes, B. A., O'Neil, D. M., Libé, R., Allolio, B., Bertagna, X., Bertherat, J., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism

Adrenal and Paraganglionic TumorsAdrenal Hormones and Disorders

Cited by 154

Male Pseudohermaphroditism Due to Multiple Defects in Steroid-Biosynthetic Microsomal Mixed-Function Oxidases: A New Variant of Congenital Adrenal Hyperplasia

Peterson, R. E., Imperato-McGinley, J., Gautier, T., & Shackleton, C. (1985) · New England Journal of Medicine

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 148

Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism

Storbeck, K.-H., Schiffer, L., Baranowski, E. S., Chortis, V., Prete, A., Barnard, L., Gilligan, L. C., Taylor, A. E., Idkowiak, J., Arlt, W., et al. (2019) · Endocrine Reviews

Adrenal Hormones and DisordersMetabolism and Genetic Disorders

Cited by 141

Pubertal Presentation of Congenital Δ5–-3β–Hydroxysteroid Dehydrogenase Deficiency*

ROSENFIELD, R. L., RICH, B. H., WOLFSDORF, J. I., CASSORLA, F., PARKS, J. S., BONGIOVANNI, A. M., WU, C. H., & SHACKLETON, C. H. L. (1980) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 135

The diagnosis of congenital adrenal hyperplasia in the newborn by gas chromatography/mass spectrometry analysis of random urine specimens

Caulfield, M. P., Lynn, T., Gottschalk, M. E., Jones, K. L., Taylor, N. F., Malunowicz, E. M., Shackleton, C. H. L., Reitz, R. E., & Fisher, D. A. (2002) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 120

Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype

Shackleton, C., Marcos, J., Arlt, W., & Hauffa, B. P. (2004) · American Journal of Medical Genetics Part A

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 104

A missense mutation in the human cytochrome b5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiency

Idkowiak, J., Randell, T., Dhir, V., Patel, P., Shackleton, C. H. L., Taylor, N. F., Krone, N., & Arlt, W. (2012) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 104

Prostate formation in a marsupial is mediated by the testicular androgen 5α-androstane-3α,17β-diol

Shaw, G., Renfree, M. B., Leihy, M. W., Shackleton, C. H. L., Roitman, E., & Wilson, J. D. (2000) · Proceedings of the National Academy of Sciences

Sexual Differentiation and DisordersSperm and Testicular Function

Cited by 101

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency

Lavery, G. G., Walker, E. A., Tiganescu, A., Ride, J. P., Shackleton, C. H. L., Tomlinson, J. W., Connell, J. M. C., Ray, D. W., Biason-Lauber, A., Malunowicz, E. M., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 95