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Cited by 215Adrenal and Paraganglionic TumorsMedical Imaging Techniques and ApplicationsNeuroendocrine Tumor Research Advances

The DOI matches its Crossref record; 47 of the 53 references it cites were found in a registry or an index.

18F-Fluorodeoxyglucose Positron Emission Tomography for the Diagnosis of Adrenocortical Tumors: A Prospective Study in 77 Operated Patients

Groussin, Lionel, Bonardel, Gérald, Silvéra, Stéphane, Tissier, Frédérique, Coste, Joël, Abiven, Gwenaelle, Libé, Rossella, Bienvenu, Marie, Alberini, Jean-Louis, Salenave, Sylvie, Bouchard, Philippe, Bertherat, Jérôme, Dousset, Bertrand, Legmann, Paul, Richard, Bruno, Foehrenbach, Hervé, Bertagna, Xavier, Tenenbaum, Florence·2009·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2008-2302
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Abstract

CONTEXT: Most adrenal incidentalomas are nonfunctioning adrenocortical adenomas (ACAs). Adrenocortical carcinomas (ACCs) are rare but should be recognized at an early stage. OBJECTIVE: The objective of the study was to evaluate the usefulness of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) to predict malignancy in patients without a previous history of cancer. DESIGN: This was a prospective, multicenter study from 2001 to 2006. SETTING: The study was conducted at a network of seven university hospitals in Paris. PATIENTS: Seventy-seven patients were included. All underwent surgery because of hypersecretory and/or growing benign lesions (n = 18), obvious ACCs (n = 21), or radiologically indeterminate lesions (n = 38). MAIN OUTCOME MEASURE: The degree of (18)F-FDG PET uptake [maximum standardized uptake value (maxSUV)] was related to the pathological findings serving as a reference, and its diagnostic value was compared with that of computerized tomography (CT) scan. RESULTS: Pathology eventually diagnosed 43 ACAs, 22 ACCs, and 12 nonadrenocortical lesions. Using a cutoff value above 1.45 for adrenal to liver maxSUV ratio, the sensitivity and specificity to distinguish ACAs from ACCs were, respectively, 1.00 (95% confidence interval 0.85-1.00) and 0.88 (95% confidence interval 0.75-0.96). Among the 38 indeterminate lesions at CT scan, we could analyze a subgroup of 16 adrenocortical tumors with high unenhanced density (>10 HU) and an inappropriate washout: (18)F-FDG PET correctly predicted the benignity in 13 of 15 ACAs. CONCLUSIONS: In a multidisciplinary team approach, (18)F-FDG PET helps to manage suspicious CT scan lesions. An adrenal to liver maxSUV ratio less than 1.45 is highly predictive of a benign lesion.

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Metadata

Authors
Groussin, L., Bonardel, G., Silvéra, S., Tissier, F., Coste, J., Abiven, G., Libé, R., Bienvenu, M., Alberini, J.-L., Salenave, S., Bouchard, P., Bertherat, J., Dousset, B., Legmann, P., Richard, B., Foehrenbach, H., Bertagna, X., & Tenenbaum, F.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • HIA du Val-de-Grâce à Paris (FR)
  • Université Paris Descartes (L.G., S.Si., F.Ti., J.C., M.B., J.B., B.D., P.L., B.R., X.B.), 75006 Paris, France
  • Institut National de la Santé et de la Recherche Médicale Unité 567, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Institut Cochin, Department of Endocrinology, Metabolism and Cancer (L.G., F.Ti., R.L., J.B., X.B.), 75014 Paris, France
  • Hôpital Cochin (FR)
  • Université Paris Descartes (FR)
  • Université de Versailles Saint-Quentin-en-Yvelines (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Nuclear Medicine (B.R., F.Te.), 75014 Paris, France
Corresponding author
Groussin, Lionel
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2009-05-01
Volume
94
Issue
5
Pages
1713-1722
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2008-2302
OpenAlex
W2044368873
Cited by
215
References
53
Citations by year
2026: 6 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 13 · 2021: 13 · 2020: 6 · 2019: 5 · 2018: 14 · 2017: 15 · 2016: 11 · 2015: 13 · 2014: 18 · 2013: 14 · 2012: 14
FWCI
22.25
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
Keywords
18F-FDG PET, adrenocortical tumors, adrenocortical carcinoma, adrenal adenoma, adrenal incidentaloma, malignancy prediction, standardized uptake value, preoperative diagnosis
MeSH terms
Adrenal Cortex Neoplasms, Adult, Aged, Blood Glucose, Female, Hormones, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Paris, Preoperative Care, Prospective Studies, Tomography, X-Ray Computed, Fluorodeoxyglucose F18, Diabetes Complications, Positron-Emission Tomography

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