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Cited by 712Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersCardiac tumors and thrombi

Prevalence of adrenal incidentaloma in a contemporary computerized tomography series

Bovio, S., Cataldi, A., Reimondo, G., Sperone, P., Novello, S., Berruti, A., Borasio, P., Fava, C. +4 more·2006·Journal of Endocrinological Investigation
DOI 10.1007/bf03344099
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Abstract

Adrenal incidentalomas, defined as masses discovered incidentally during imaging investigation of non-adrenal disorders, have become a rather common finding in clinical practice. The prevalence is not well characterized and varies among studies. The aim of the present study was to perform a prospective evaluation of the prevalence of adrenal incidentalomas among subjects undergoing computerized tomography (CT) scan of the chest in a screening program of lung cancer (Tic TAC study) in Piedmont, a region of Northwestern Italy. This evaluation included 520 subjects (382 males and 138 females, aged between 55-82 yr), referred to our hospital from April to December 2001. Twenty-three patients with adrenal masses were identified: 21 adrenal adenomas, 1 myelolipoma, and 1 metastasis of lung cancer. Therefore, the overall prevalence of adrenal lesions was 4.4%, and that of benign adrenal masses was 4.2%. This prevalence is higher than those found in previous CT scan series reported in the literature, probably because of the use of high-resolution CT scanning technology. Another factor that influenced our results is that subject age is skewed towards the decades characterized by a greater occurrence of adrenal masses. The outcome of this study confirms that we are presently able to identify incidentally discovered adrenal masses more often than in early years and that the prevalence of adrenal incidentalomas on CT images is approaching that of autopsy series. The present study provides a reliable estimate of the prevalence of adrenal incidentaloma with currently used CT scanners. Notwithstanding that our subjects were at increased risk of lung cancer, the rate of adrenal metastases was low. We think that the present results can be generalized even if we may disclose the lack of histological diagnosis.

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  • Over the last 2 decades, there has been a dramatic increase in the detection of AIs; series with contemporary high-resolution CT techniques report a prevalence close to that observed at autopsy.

    “Over the last 2 decades, there has been a dramatic increase in the detection of AIs; series with contemporary high-resolution CT techniques report a prevalence close to that observed at autopsy (Table 2 (36-44)).”

    From Adrenal incidentaloma (2020) · cites this paper as [41]

  • In 2006, Bovio et al. reported a frequency of AIs of 4.4% in a prospective study of 520 patients, significantly higher than previous imaging series.

    “In 2006, Bovio et al. (41) reported a frequency of AIs of 4.4% in a prospective study of 520 patients. This was significantly higher than the previous imaging series.”

    From Adrenal incidentaloma (2020) · cites this paper as [41]

  • Adrenal incidentalomas are thought to occur in up to 4-7% of adults.

    “Because AI are thought to be present in up to 4 -7% of adults (6 -11)”

    From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [8]

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Authors
Bovio, S., Cataldi, A., Reimondo, G., Sperone, P., Novello, S., Berruti, A., Borasio, P., Fava, C., Dogliotti, L., Scagliotti, G. V., Angeli, A., & Terzolo, M.
Affiliations
University of Turin (IT)
Corresponding author
Terzolo, M.
ORCID
Venue
Journal of Endocrinological Investigation
Publisher
Springer Science and Business Media LLC
Published
2006-04
Volume
29
Issue
4
Pages
298-302
ISSN
  • 0391-4097 (ISSN-L)
  • 1720-8386
DOI
10.1007/bf03344099
OpenAlex
W2117360867
Cited by
712
References
55
Citations by year
2026: 17 · 2025: 34 · 2024: 30 · 2023: 41 · 2022: 42 · 2021: 54 · 2020: 49 · 2019: 37 · 2018: 44 · 2017: 39 · 2016: 38 · 2015: 45 · 2014: 38 · 2013: 38 · 2012: 27
FWCI
18.64
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Endocrinological Investigation (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
Keywords
adrenal incidentaloma, prevalence, adrenal adenoma, adrenal myelolipoma, adrenal metastasis, lung cancer screening, high-resolution computed tomography, age-related incidence
MeSH terms
Adrenal Gland Neoplasms, Aged, Female, Humans, Lung Neoplasms, Male, Mass Screening, Middle Aged, Prospective Studies, Tomography, X-Ray Computed, Prevalence, Incidental Findings

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