Mutations of β-Catenin in Adrenocortical Tumors: Activation of the Wnt Signaling Pathway Is a Frequent Event in both Benign and Malignant Adrenocortical Tumors
Abstract
Adrenocortical cancer is a rare cancer with a very poor prognosis. The genetic alterations identified to date in adrenocortical tumors are limited. Activating mutations of the Wnt signaling pathway have been observed in more frequent cancers, particularly digestive tract tumors. We investigated whether Wnt pathway activation is involved in adrenocortical tumorigenesis. In a series of 39 adrenocortical tumors, immunohistochemistry revealed abnormal cytoplasmic and/or nuclear accumulation of beta-catenin in 10 of 26 adrenocortical adenomas and in 11 of 13 adrenocortical carcinomas. An activating somatic mutation of the beta-catenin gene was shown in 7 of 26 adrenocortical adenomas and in 4 of 13 adrenocortical carcinomas; these mutations were observed only in adrenocortical tumors with abnormal beta-catenin accumulation and most were point mutations altering the Ser45 of exon 3 (in the consensus GSK3-beta/CK1 phosphorylation site). Functional studies showed that the activating Ser45 beta-catenin mutation found in the adrenocortical cancer H295R cell line leads to constitutive activation of T-cell factor-dependent transcription. This is the first molecular defect to be reported with the same prevalence in both benign (27%) and malignant (31%) adrenocortical tumors. beta-Catenin mutations are also the most frequent genetic defect currently known in adrenocortical adenomas. In adrenocortical adenomas, beta-catenin alterations are more frequent in nonfunctioning tumors, suggesting that beta-catenin pathway activation might be mostly involved in the development of nonsecreting adrenocortical adenomas and adrenocortical carcinomas. The very frequent and substantial accumulation of beta-catenin in adrenocortical carcinomas suggests that other alterations might also be involved. This finding may contribute to new therapeutic approaches targeting the Wnt pathway in malignant adrenocortical tumors, for which limited medical therapy is available.
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Activating point mutations in CTNNB1 are identified in over 25% of both ACAs and ACCs in children and adults.
“mutational analysis of the effector of the canonical Wnt pathway, the β-catenin gene, CTNNB1, has identified activating point mutations in over 25% of both ACAs and ACCs in children and adults (149, 206–208).”
From Adrenocortical carcinoma (2014) · cites this paper as [149]
Immunohistochemical analysis of 39 adrenal tumors revealed accumulation of β-catenin in 10 of 26 ACAs and in 11 of 13 ACCs.
“Immunohistochemical analysis of 39 adrenal tumors revealed accumulation of β-catenin in 10 of 26 ACAs and in 11 of 13 ACCs, consistent with stabilized and hence activated β-catenin (149).”
From Adrenocortical carcinoma (2014) · cites this paper as [149]
Mutational analysis of CTNNB1 identified activating point mutations in both ACAs and ACCs.
“Furthermore, mutational analysis of the β-catenin gene CTNNB1 identified activating point mutations in both ACAs and ACCs (149, 206–208).”
From Adrenocortical carcinoma (2014) · cites this paper as [149]
An activating Ser45 β-catenin mutation and activated β-catenin signaling were identified in the NCI-H295 ACC cell line.
“An activating Ser45 β-catenin mutation as well as activated β-catenin signaling was also identified in the NCI-H295 ACC cell line (149).”
From Adrenocortical carcinoma (2014) · cites this paper as [149]
Cites
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Morin, P. J., Sparks, A. B., Kořínek, V., Barker, N., Clevers, H. C., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.275.5307.1787 · Cited by 3,983 · see citing works
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183 · see citing works
Activating Mutations of the Stimulatory G Protein in the McCune–Albright Syndrome
Weinstein, L. S., Shenker, A., Gejman, P. V., Merino, M. J., Friedman, E., & Spiegel, A. M. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112123252403 · Cited by 1,680 · see citing works
Caught up in a Wnt storm: Wnt signaling in cancer
Giles, R. H., van Es, J. H., & Clevers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00005-2 · Cited by 1,482 · see citing works
Kirschner, L. S., Carney, J. A., Pack, S. D., Taymans, S. E., Giatzakis, C., Cho, Y. S., Cho-Chung, Y. S., & Stratakis, C. A. (2000) · Nature Genetics · doi:10.1038/79238 · Cited by 1,153 · see citing works
Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas
Coste, A. D. L., Romagnolo, B., Billuart, P., Renard, C.-A., Buendia, M., Soubrane, O., Fabrè, M., Chelly, J., Beldjord, C., Kahn, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8847 · Cited by 1,121 · see citing works
Self-citationSatoh, S., Daigo, Y., Furukawa, Y., Kato, T., Miwa, N., Nishiwaki, T., Kawasoe, T., Ishiguro, H., Fujita, M., Tokino, T., et al. (2000) · Nature Genetics · doi:10.1038/73448 · Cited by 960 · see citing works
Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors
Weiss, L. M. (1984) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198403000-00001 · Cited by 920 · cited 1× · see citing works
“The sections were examined to assess their Weiss score (0 to 9) on the basis of the presence or absence of the following nine histologic features: high mitotic rate, atypical mitoses, high nuclear grade, low percentage of clear cells, necrosis, diffuse tumor architecture, capsular invasion, sinusoidal invasion, and ve…”
BackgroundLuton, J.-P., Cerdas, S., Billaud, L., Thomas, G., Guilhaume, B., Bertagna, X., Laudat, M.-H., Louvel, A., Chapuis, Y., Blondeau, P., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004263221705 · Cited by 717 · see citing works
Self-citationMultiple Primary Cancers in Families With Li-Fraumeni Syndrome
Hisada, M., Garber, J. E., Li, F. P., Fung, C. Y., & Fraumeni, J. F. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.8.606 · Cited by 553 · see citing works
Icard, P., Goudet, P., Charpenay, C., Andreassian, B., Carnaille, B., Chapuis, Y., Cougard, P., Henry, J., & Proye, C. (2001) · World Journal of Surgery · doi:10.1007/s00268-001-0047-y · Cited by 543 · see citing works
New targets of β-catenin signaling in the liver are involved in the glutamine metabolism
Cadoret, A., Ovejero, C., Terris, B., Souil, E., Lévy, L., Lamers, W. H., Kitajewski, J., Kahn, A., & Perret, C. (2002) · Oncogene · doi:10.1038/sj.onc.1206118 · Cited by 412 · see citing works
Self-citationDistinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
Giordano, T. J., Thomas, D. G., Kuick, R., Lizyness, M., Misek, D. E., Smith, A. L., Sanders, D., Aljundi, R. T., Gauger, P. G., Thompson, N. W., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63846-1 · Cited by 383 · see citing works
Beta-catenin mutation in carcinoma of the uterine endometrium.
Fukuchi, T., Sakamoto, M., Tsuda, H., Maruyama, K., Nozawa, S., & Hirohashi, S. (1998) · PubMed · Cited by 361 · see citing works
beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer.
Clements, W. M., Wang, J., Sarnaik, A. A., Kim, O. J., MacDonald, J., Fenoglio‐Preiser, C. M., Groden, J. L., & Lowy, A. M. (2002) · PubMed · Cited by 357 · see citing works
Gicquel, C., BERTAGNA, X. Y., Gaston, V., Coste, J., Louvel, A., Baudin, É., Bertherat, J. Y., Chapuis, Y., Duclos, J. M., Schlumberger, M. J., et al. (2001) · PubMed · Cited by 285 · see citing works
Self-citationMacfarlane, D. A. (1958) · PubMed · Cited by 266 · see citing works
Mirabelli-Primdahl, L., Gryfe, R., Kim, H., Millar, A. H., Luceri, C., Dale, D., Holowaty, E. J., Bapat, B. V., Gallinger, S., & Redston, M. S. (1999) · PubMed · Cited by 262 · see citing works
de Fraipont, F., El Atifi, M., Cherradi, N., Le Moigne, G., Defaye, G., Houlgatte, R., Bertherat, J., Bertagna, X., Plouin, P.-F., Baudin, E., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1075 · Cited by 261 · see citing works
Self-citationTumor formation by genetic mutations in the components of the Wnt signaling pathway
Kikuchi, A. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01424.x · Cited by 258 · see citing works
Bertherat, J. Y., Groussin, L., Sandrini, F., Matyakhina, L., Bei, T. A., Stergiopoulos, S. G., Papageorgiou, T., Bourdeau, I., Kirschner, L. S., Vincent-Dejean, C., et al. (2003) · PubMed · Cited by 250 · see citing works
Self-citationManagement of adrenocortical carcinoma
Allolio, B., Hahner, S., Weismann, D., & Fassnacht, M. (2004) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01881.x · Cited by 214 · see citing works
Groussin, L., Kirschner, L. S., Vincent-Dejean, C., Perlemoine, K., Jullian, E. H., Delemer, B., Zacharieva, S., Pignatelli, D., Carney, J. A., LUTON, J. P., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/344579 · Cited by 192 · see citing works
Self-citationGroussin, L., Perlemoine, K., Contesse, V., Lefèbvre, H., Tabarin, A., Thiéblot, P., Schlienger, J. L., LUTON, J. P., BERTAGNA, X. Y., & Bertherat, J. Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8458 · Cited by 82 · see citing works
Self-citationYanagisawa, N., Mikami, T., Saegusa, M., et al. (2001) · PubMed · Cited by 78 · see citing works
Recent advances in the pathogenesis of adrenocortical tumours
Gicquel, C., BERTAGNA, X. Y., & Bouc, Y. L. (1995) · European Journal of Endocrinology · doi:10.1530/eje.0.1330133 · Cited by 65 · see citing works
Self-citationGroussin, L., Massias, J. F., BERTAGNA, X. Y., & Bertherat, J. Y. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6307 · Cited by 64 · see citing works
Self-citationBläker, H., Sutter, C., Kadmon, M., Otto, H. F., Doeberitz, M. V. K., Gebert, J. F., & Helmke, B. M. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20071 · Cited by 60 · see citing works
Mutations in Adrenocortical Tumors
Reincke, M. (1998) · Hormone and Metabolic Research · doi:10.1055/s-2007-978913 · Cited by 57 · see citing works
Semba, S., Kusumi, R., Moriya, T., et al. (2000) · Endocrine Pathology · doi:10.1385/ep:11:3:243 · Cited by 53 · see citing works
Genetics of adrenocortical tumors: gatekeepers, landscapers and conductors in symphony
Stratakis, C. A. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.08.005 · Cited by 50 · see citing works
Koppert, L. B., van der Velden, A. W., van de Wetering, M., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601589 · Cited by 30 · see citing works
Rosenberg, D., Groussin, L., Jullian, E. H., Perlemoine, K., Medjane, S., Louvel, A., BERTAGNA, X. Y., & Bertherat, J. Y. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030070 · Cited by 28 · see citing works
Self-citationInherited colon cancer as an example of a multistep process model
Luft, F. C. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00204973 · Cited by 2 · see citing works
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Program, T. M. V., Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0205-x · Cited by 1,381 · see citing works
Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
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Assié, G., Letouzé, E., Fassnacht, M., Jouinot, A., Luscap, W., Barreau, O., Omeiri, H., Rodriguez, S., Perlemoine, K., René-Corail, F., et al. (2014) · Nature Genetics · doi:10.1038/ng.2953 · Cited by 732 · see citing works
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Zheng, S., Cherniack, A. D., Dewal, N., Moffitt, R. A., Danilova, L., Murray, B. A., Lerario, A. M., Else, T., Knijnenburg, T. A., Ciriello, G., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.04.002 · Cited by 657 · see citing works
Self-citationAbiven, G., Coste, J., Groussin, L., Anract, P., Tissier, F., Legmann, P., Dousset, B., Bertagna, X., & Bertherat, J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2730 · Cited by 435 · see citing works
Self-citation<i>ARMC5</i>Mutations in Macronodular Adrenal Hyperplasia with Cushing's Syndrome
Assié, G., Libé, R., Espiard, S., Rizk-Rabin, M., Guimier, A., Luscap, W., Barreau, O., Lefèvre, L., Sibony, M., Guignat, L., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1304603 · Cited by 395 · see citing works
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Fassnacht, M., Libé, R., Kroiss, M., & Allolio, B. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.235 · Cited by 396 · see citing works
Groussin, L., Bonardel, G., Silvéra, S., Tissier, F., Coste, J., Abiven, G., Libé, R., Bienvenu, M., Alberini, J.-L., Salenave, S., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2302 · Cited by 215 · see citing works
Self-citationKim, A. C., Reuter, A. L., Zubair, M., Else, T., Serecky, K., Bingham, N. C., Lavery, G. G., Parker, K. L., & Hammer, G. D. (2008) · Development · doi:10.1242/dev.021493 · Cited by 202 · see citing works
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Xing, Y., Lerario, A. M., Rainey, W., & Hammer, G. D. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.001 · Cited by 174 · see citing works
Heaton, J. H., Wood, M. A., Kim, A. C., Lima, L. O., Barlaskar, F. M., Almeida, M. Q., Fragoso, M. C. B. V., Kuick, R., Lerario, A. M., Simon, D. P., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.05.026 · Cited by 173 · see citing works
Frequent mutations of <i>β‐catenin</i> gene in sporadic secreting adrenocortical adenomas*
Tadjine, M., Lampron, A., Ouadi, L., & Bourdeau, I. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03033.x · Cited by 153 · see citing works
Ragazzon, B., Libé, R., Gaujoux, S., Assié, G., Fratticci, A., Launay, P., Clauser, E., Bertagna, X., Tissier, F., de Reyniès, A., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2014 · Cited by 152 · see citing works
Self-citationGaujoux, S., Grabar, S., Fassnacht, M., Ragazzon, B., Launay, P., Libé, R., Chokri, I., Audebourg, A., Royer, B., Sbiera, S., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2006 · Cited by 146 · see citing works
Self-citationGaujoux, S., Tissier, F., Groussin, L., Libé, R., Ragazzon, B., Launay, P., Audebourg, A., Dousset, B., Bertagna, X., & Bertherat, J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0631 · Cited by 142 · see citing works
Self-citationThe Wnt/beta-catenin pathway in adrenocortical development and cancer
El Wakil, A., & Lalli, E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.014 · Cited by 134 · see citing works
Bonnet, S., Gaujoux, S., Launay, P., Baudry, C., Chokri, I., Ragazzon, B., Libé, R., René-Corail, F., Audebourg, A., Vacher-Lavenu, M.-C., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1885 · Cited by 133 · see citing works
Self-citationPKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
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Berthon, A., Martinez, A., Bertherat, J., & Val, P. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.009 · Cited by 125 · see citing works
Self-citationLibè, R., Groussin, L., Tissier, F., Elie, C., René-Corail, F., Fratticci, A., Jullian, E., Beck-Peccoz, P., Bertagna, X., Gicquel, C., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2085 · Cited by 115 · see citing works
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Ronchi, C. L., Di Dalmazi, G., Faillot, S., Sbiera, S., Assié, G., Weigand, I., Calebiro, D., Schwarzmayr, T., Appenzeller, S., Rubin, B., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1586 · Cited by 93 · see citing works
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Nakamura (2015) · doi:10.1016/j.ecl.2015.02.007 · Cited by 55 · see citing works
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Papotti, M., Duregon, E., Volante, M., & McNicol, A. M. (2014) · Endocrine Pathology · doi:10.1007/s12022-013-9291-6 · Cited by 33 · see citing works
Investigation of BRAFand CTNNB1 activating mutations in adrenocortical tumors
Masi, G., Lavezzo, E., Iacobone, M., Favia, G., Palù, G., & Barzon, L. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346515 · Cited by 29 · see citing works
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- Authors
- Tissier, F., Cavard, C., Groussin, L., Perlemoine, K., Fumey, G., Hagneré, A.-M., René-Corail, F., Jullian, E., Gicquel, C., Bertagna, X., Vacher-Lavenu, M.-C., Perret, C., & Bertherat, J.
- Affiliations
- 1Endocrinology and Departments of
- Centre National de la Recherche Scientifique (FR)
- 3Pathology and
- Hôpital Cochin (FR)
- Hôpital Armand-Trousseau (FR)
- Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale (FR)
- Venue
- Cancer Research
- Published
- 2005-09-01
- Volume
- 65
- Issue
- 17
- Pages
- 7622-7627
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2157610967
- Cited by
- 474
- References
- 34
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 12 · 2023: 15 · 2022: 23 · 2021: 29 · 2020: 28 · 2019: 28 · 2018: 28 · 2017: 33 · 2016: 27 · 2015: 29 · 2014: 25 · 2013: 25 · 2012: 23
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- CTNNB1 mutation, Wnt signaling, adrenocortical tumors, adrenal adenoma, adrenocortical carcinoma
- MeSH terms
- Adrenal Cortex Neoplasms, Adult, Aged, Cytoskeletal Proteins, Female, Humans, Immunohistochemistry, Male, Middle Aged, Mutation, Signal Transduction, Trans-Activators, Adrenocortical Carcinoma, Intercellular Signaling Peptides and Proteins, Cell Line, Tumor, Wnt Proteins, beta Catenin
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