The DOI matches its Crossref record; 43 of the 47 references it cites were found in a registry or an index.
Precocious Pubarche: Distinguishing Late-Onset Congenital Adrenal Hyperplasia from Premature Adrenarche
Abstract
CONTEXT: Because precocious pubarche (PP) reveals late-onset congenital adrenal hyperplasia (LO-CAH) in 5 to 20% of cases, an adrenal stimulation test is recommended in all patients presenting with it. This test is stressful and expensive, and results are normal in more than 80% of cases. OBJECTIVE: Our objective was to identify clinical and plasma predictors of LO-CAH among patients presenting with PP. DESIGN, SETTING, AND PATIENTS: We conducted a retrospective cohort study that included all patients seen for PP at our hospital between 1999 and 2006 (n = 238). All had undergone an ACTH test. MAIN OUTCOME MEASURE: LO-CAH was defined by a post-ACTH 17-hydroxyprogesterone (17-OHP) plasma level greater than 10 ng/ml and confirmed by mutational analysis of the CYP21 gene. The association of standard clinical and laboratory indicators with LO-CAH was assessed. RESULTS: Ten (4%) of 238 patients had LO-CAH. Basal 17-OHP, Delta4-androstenedione, and testosterone plasma levels were significantly higher in these patients. A 2-ng/ml threshold for basal 17-OHP plasma levels offered 100% (95% CI, 69-100) sensitivity for the diagnosis of LO-CAH and 99% (95% CI, 96-100) specificity. CONCLUSION: We identified three plasma predictors of LO-CAH in patients presenting with PP. A selective strategy based on a 2-ng/ml basal 17-OHP plasma level threshold would have safely avoided 99% of the unnecessary ACTH tests among our patients.
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“This is in contrast with previous studies reporting advanced BA maturation in children with PP due to NCCAH (20,21).”
From Relationship of CYP21A2 genotype and serum 17-hydroxyprogesterone and cortisol levels in a large cohort of Italian children with premature pubarche (2011) · cites this paper as [21]
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“The cut point of a basal 17-hydroxyprogesterone >200 ng/dL has been suggested as the threshold for performing ACTH stimulation tests [148].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [148]
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Hanley, J. A., & McNeil, B. J. (1983) · Radiology · doi:10.1148/radiology.148.3.6878708 · Cited by 7,016
Variations in pattern of pubertal changes in girls
Marshall, W. A., & Tanner, J. M. (1969) · Archives of Disease in Childhood · doi:10.1136/adc.44.235.291 · Cited by 5,963
Variations in the pattern of pubertal changes in boys
Marshall, W. A., & Tanner, J. M. (1970) · Archives of Disease in Childhood · doi:10.1136/adc.45.239.13 · Cited by 5,147
Williams Textbook of Endocrinology
Melmed, S., & Polonsky, K. S. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,715
Congenital adrenal hyperplasia.
Merke, D. P., & Bornstein, S. R. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66736-0 · Cited by 628
Genotyping steroid 21-hydroxylase deficiency: hormonal reference data
NEW, M. I., LORENZEN, F., LERNER, A. J., KOHN, B., OBERFIELD, S. E., POLLACK, M. S., DUPONT, B., STONER, E., LEVY, D. J., PANG, S., et al. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-320 · Cited by 624
Puberty : ontogeny, neuroendocrinology, physiology, and disorders
Styne, D. M., Grumbach, M. M., Dennis, M., Styne, J., & Melvin, M. N. (1998) · Time to knit · doi:10.1016/b978-1-4160-2911-3.50026-1 · Cited by 546
High frequency of nonclassical steroid 21-hydroxylase deficiency
SPEISER, P. W., DUPONT, B. O., RUBINSTEIN, P., PIAZZA, A., KASTELAN, A., & NEW, M. I. (1986) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198604000-00017 · Cited by 523
Congenital Adrenal Hyperplasia
Levy, J. B., & Husmann, D. A. (1996) · The Journal of Urology · doi:10.1097/00005392-199608001-00060 · Cited by 415
Premature Adrenarche--Normal Variant or Forerunner of Adult Disease?
Ibáñez, L., DiMartino-Nardi, J., Potau, N., & Saenger, P. H. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0416 · Cited by 414
Flagged first, then by citations
4 of the 47 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Sempe, 1979, Auxologie, Méthodes et séquences., Paris, Theraplix
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Sorted by citations
Items 101–134 of 134
Clinical practice guidelines "Congenital adrenal hyperplasia in children" with comments
Чугунов, І., Kopylova, I., Kolodkina, A. A., Kalinchenko, N. Y., Vorontsova, M. V., Bezlepkina, O. B., Peterkova, V. A., & Mokrysheva, N. G. (2026) · Problems of Endocrinology · doi:10.14341/probl13767 · Cited by 1
Stoeva, I., Kostova, A., Moskova, M., Тодорова, А., Todorov, T., Kirov, A., & Aroyo, A. (2014) · Scripta Scientifica Medica · doi:10.14748/ssm.v46i4.1014 · Cited by 1
Hughes, I. A., & Chatterjee, K. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00104-0 · Cited by 1
Genotype in the diagnosis of 21-hydroxylase deficiency: who should undergo CYP21A2 analysis?
Cavarzere, P., Vincenzi, M., Teofoli, F., Gaudino, R., Lauriola, S., Maines, E., Camilot, M., & Antoniazzi, F. (2013) · PubMed · doi:10.3275/9096 · Cited by 1
Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma
Kawaguchi, Y., Mizuno, H., Horikawa, M., Kano, M., Yamada, K., Yamakawa, F., Maekawa, T., Yamazaki, Y., McNamara, K. M., Sasano, H., et al. (2017) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.241.125 · Cited by 1
Importância da prova de Synacthen no diagnóstico diferencial de pubarca precoce
Santos, M. J., Amaral, D., Limbert, C., Piña, R., & Lopes, L. (2015) · Revista Portuguesa de Endocrinologia Diabetes e Metabolismo · doi:10.1016/j.rpedm.2015.05.004
Yamada, T., & Demura, S. (2013) · International Journal of Health · doi:10.14419/ijh.v1i2.1014
Een ongebruikelijke presentatie van het late onset adrenogenitaal syndroom
Spijker, E. E., Mul, D., & Reeser, H. M. (2011) · Tijdschrift voor kindergeneeskunde · doi:10.1007/s12456-011-0018-7
Pasqualini, T. (2013) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2013.e35
Reisch, N., & Reincke, M. (2012) · Der Gynäkologe · doi:10.1007/s00129-011-2904-6
Non-classic congenital adrenal hyperplasia. Clinical experience versus clinical guidelines
SHAH, A. S., & Backeljauw, P. F. (2011) · Endocrinology Studies · doi:10.4081/es.2011.e11
Franz, R., Melnik, B. C., Zouboulis, C. C., Ring, J., & Chen, W. (2013) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-24767-5_35
Dörr, H. G., Schulze, N., Bettendorf, M., Binder, G., Bonfig, W., Denzer, C., Dunstheimer, D., Salzgeber, K., Schmidt, H., Schwab, K. O., et al. (2020) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-020-00976-y
Gonadotrophin-Independent Precocious Puberty; Female and Male
Drop, S. L. S., & der Grinten, H. L. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11101-8
Polat, S., & Arslan, Y. K. (2021) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.galenos.2020.2021.0184
Congenital Adrenal Hyperplasia
Trapp, C. M., Levine, L. S., & Oberfield, S. E. (2013) · Humana Press eBooks · doi:10.1007/978-1-60761-395-4_13
(2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328339f31e
Sultan, C., Gaspari, L., Kalfa, N., & Paris, F. (2017) · ISGE series · doi:10.1007/978-3-319-41433-1_5
Brauner, R. (2013) · EMC - Pédiatrie - Maladies infectieuses · doi:10.1016/s1637-5017(13)61652-x
Self-citation21-Hydroxylase Deficiency: Clinical and Biochemical Aspects
Nordenström, A., & Lajić, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65208-x
Brauner, R. (2013) · EMC - Pediatría · doi:10.1016/s1245-1789(13)65518-3
Self-citation(2012) · Elsevier eBooks · doi:10.1016/b978-3-437-41797-9.16001-7
Kılavuz, S., Bezen, D., Süt, N., Dilek, E., & Tütüncüler, F. (2022) · Çukurova medical journal (Online)/Çukurova medical journal · doi:10.17826/cumj.1176227
Disorders of Puberty and Their Management
Dunkel, L., Saengkaew, T., & Howard, S. R. (2023) · Endocrinology · doi:10.1007/978-3-030-18901-3_6-1
Premature pubarche during minipuberty – literature review and two case reports
Rakuś-Kwiatosz, A., Budzyńska, E., & Beń‐Skowronek, I. (2023) · Pediatric Endocrinology Diabetes and Metabolism · doi:10.5114/pedm.2023.129343
Case 1: Clitoromegaly, Oligomenorrhea, and Hirsutism in a 17-year-old Transgender Male
Ahmed, S., Oberlin, J. M., & Bowsher, B. (2024) · Pediatrics in Review · doi:10.1542/pir.2022-005608
Disorders of Puberty and Their Management
Dunkel, L., Saengkaew, T., & Howard, S. R. (2024) · Endocrinology · doi:10.1007/978-3-030-23709-7_6
21-Hydroxylase deficiency: Clinical and biochemical aspects
Nordenström, A., & Lajić, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00171-0
Congenital Adrenal Hyperplasia
Witchel, S. F., Oberfield, S. E., Fisher, A. S., & Trapp, C. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-66296-6_11
Infertilidad femenina de origen endocrino
Bidet, M., Difadi, S., & Bales, D. (2025) · EMC - Ginecología-Obstetricia · doi:10.1016/s1283-081x(25)50713-0 · Cited by 1
FERREIRA, B., Robin, G., Pigny, P., Bachelot, A., RIBIERE, L., & Catteau-Jonard, S. (2026) · Gynecological Endocrinology · doi:10.1080/09513590.2026.2659979
Clinical Characteristics and Thyroid Findings in Children with Isolated Premature Adrenarche
Aka, S., Koçyiğit, Ş., Abalı, S., & Semiz, S. (2026) · Children · doi:10.3390/children13091221
Metadata
- Authors
- Armengaud, J.-B., Charkaluk, M.-L., Trivin, C., Tardy, V., Bréart, G., Brauner, R., & Chalumeau, M.
- Affiliations
- Inserm (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Necker-Enfants Malades (FR)
- Groupement Hospitalier Est (V.T.), Centre de Biologie et Pathologie Est, 69677 Bron, France
- Institut National de la Santé et de la Recherche Médicale U953 (J.-B.A., G.B., M.C.), 75014 Paris, France
- Corresponding author
- Chalumeau, Martin
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2009-08-01
- Volume
- 94
- Issue
- 8
- Pages
- 2835-2840
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2078368333
- Cited by
- 135
- References
- 47
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 13 · 2019: 10 · 2018: 10 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 11 · 2012: 10
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- precocious pubarche, late-onset congenital adrenal hyperplasia, premature adrenarche, 17-hydroxyprogesterone, ACTH stimulation test, CYP21, Δ4-androstenedione, testosterone, diagnostic thresholds, unnecessary testing
- MeSH terms
- Adrenal Hyperplasia, Congenital, Adrenocorticotropic Hormone, Androstenedione, Child, Child, Preschool, Female, Humans, Infant, Male, Puberty, Precocious, Retrospective Studies, Testosterone, 17-alpha-Hydroxyprogesterone, Adrenarche
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