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Association of Serum TSH with High Body Mass Differs between Smokers and Never-Smokers
Abstract
CONTEXT: Recent studies have suggested that the association of low thyroid function with high body mass is restricted to nonsmokers. OBJECTIVE: The aim was to study the association of thyroid function with body mass separately for smokers and never-smokers. DESIGN AND SETTING: We conducted a cross-sectional, population-based study. SUBJECTS: We studied 27,097 individuals older than 40 yr of age who were without previously known thyroid disease. MAIN OUTCOME MEASURES: We measured mean body mass index (BMI) and odds ratio for obesity (BMI > or = 30.0 kg/m(2)) according to categories of thyroid function, in women and men, and separately for current smokers and never-smokers. We also studied the association with BMI within the reference range of TSH (0.50-3.5 mU/liter). RESULTS: TSH within the reference range was positively associated with BMI (P for trend < or = 0.001 in all groups) and with the prevalence of obesity (P for trend < 0.005 in all groups). Among women, the association did not differ between current smokers and never-smokers, but in men the association was stronger for current smokers. Hypothyroid function was associated with higher BMI and higher prevalence of obesity in women (subclinical and overt hypothyroidism) and men (subclinical hypothyroidism), both in current smokers and in never-smokers. CONCLUSION: The association of low thyroid function with high body mass was as least as strong in current smokers as in never-smokers, and our results clearly show that the association is not limited to nonsmokers, as previously suggested.
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“Higher TSH levels were associated with increased BMI [65, 66], and in longitudinal studies, individuals with rising TSH levels over time exhibited greater weight gain [67, 68].”
From Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice (2023) · cites this paper as [66]
In the citing paper
“Furthermore, a multitude of physiological and pathophysiological influences modulates the relationship between TSH and thyroid hormones at various sites of action, thereby influencing the location of the set point in health and disease (Table 2) (8, 9, 76, 91–111).”
From Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment (2015) · cites this paper as [96]
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Metadata
- Authors
- Åsvold, B. O., Bjøro, T., & Vatten, L. J.
- Affiliations
- Department of Public Health (B.O.A., L.J.V.), Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway
- Oslo University Hospital (NO)
- Norwegian University of Science and Technology (NO)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2009-12-01
- Volume
- 94
- Issue
- 12
- Pages
- 5023-5027
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1994389312
- Cited by
- 149
- References
- 17
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 2 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 5 · 2016: 12 · 2015: 10 · 2014: 15 · 2013: 11 · 2012: 7
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Funders
- Norges Teknisk-Naturvitenskapelige Universitet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- thyroid-stimulating hormone, body mass index, obesity, smoking, subclinical hypothyroidism, overt hypothyroidism, sex differences, older adults
- MeSH terms
- Body Weight, Female, Humans, Hypothyroidism, Male, Norway, Obesity, Smoking, Thyroid Function Tests, Thyrotropin, Thyroxine, Triiodothyronine, Body Mass Index, Young Adult
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