The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Predictive Value of Different Measures of Obesity for Incident Cardiovascular Events and Mortality
Abstract
CONTEXT: To date, it is unclear which measure of obesity is the most appropriate for risk stratification. OBJECTIVE: The aim of the study was to compare the associations of various measures of obesity with incident cardiovascular events and mortality. DESIGN AND SETTING: We analyzed two German cohort studies, the DETECT study and SHIP, including primary care and general population. PARTICIPANTS: A total of 6355 (mean follow-up, 3.3 yr) and 4297 (mean follow-up, 8.5 yr) individuals participated in DETECT and SHIP, respectively. INTERVENTIONS: We measured body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR) and assessed cardiovascular and all-cause mortality and the composite endpoint of incident stroke, myocardial infarction, or cardiovascular death. RESULTS: In both studies, we found a positive association of the composite endpoint with WHtR but not with BMI. There was no heterogeneity among studies. The relative risks in the highest versus the lowest sex- and age-specific quartile of WHtR, WC, WHR, and BMI after adjustment for multiple confounders were as follows in the pooled data: cardiovascular mortality, 2.75 (95% confidence interval, 1.31-5.77), 1.74 (0.84-3.6), 1.71 (0.91-3.22), and 0.74 (0.35-1.57), respectively; all-cause mortality, 1.86 (1.25-2.76), 1.62 (1.22-2.38), 1.36 (0.93-1.69), and 0.77 (0.53-1.13), respectively; and composite endpoint, 2.16 (1.39-3.35), 1.59 (1.04-2.44), 1.49 (1.07-2.07), and 0.57 (0.37-0.89), respectively. Separate analyses of sex and age groups yielded comparable results. Receiver operating characteristics analysis yielded the highest areas under the curve for WHtR for predicting these endpoints. CONCLUSIONS: WHtR represents the best predictor of cardiovascular risk and mortality, followed by WC and WHR. Our results discourage the use of the BMI.
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Mokdad, A. H. (2004) · JAMA · doi:10.1001/jama.291.10.1238 · Cited by 5,211
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General and abdominal adiposity and risk of death in Europe
Pischon, T., Boeing, H., Hoffmann, K., Bergmann, M., Schulze, M. B., Overvad, K., van der Schouw, Y. T., Spencer, E., Moons, K. G. M., Tjønneland, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801891 · Cited by 2,155
Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
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Cited by
Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050
Browning, L. M., Hsieh, S. D., & Ashwell, M. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000144 · Cited by 1,400
Omega-3 fatty acids in obesity and metabolic syndrome: A mechanistic update
Albracht-Schulte, K., Kalupahana, N. S., Ramalingam, L., Wang, S., Rahman, S. M., Robert-McComb, J., & Moustaid-Moussa, N. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.012 · Cited by 355
“Other limitations on current human studies of n-3 PUFA supplementation include the use of less reliable anthropometric methods [92] and failure to dose according to body weight to meet the threshold of tissue membrane n-3 PUFA phospholipid enrichment [93].”
BackgroundCarmienke, S., Freitag, M. H., Pischon, T., Schlattmann, P., Fankhaenel, T., Goebel, H., & Gensichen, J. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.61 · Cited by 288
Holtfreter, B., Empen, K., Gläser, S., Lorbeer, R., Völzke, H., Ewert, R., Kocher, T., & Dörr, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084603 · Cited by 79
Self-citation
Metadata
- Authors
- Schneider, H. J., Friedrich, N., Klotsche, J., Pieper, L., Nauck, M., John, U., Dörr, M., Felix, S., Lehnert, H., Pittrow, D., Silber, S., Völzke, H., Stalla, G. K., Wallaschofski, H., & Wittchen, H.-U.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2010-04-01
- Volume
- 95
- Issue
- 4
- Pages
- 1777-1785
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2096237171
- Cited by
- 457
- References
- 9
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schneider, H. J., Friedrich, N., Klotsche, J., Pieper, L., Nauck, M., John, U., Dörr, M., Felix, S., Lehnert, H., Pittrow, D., Silber, S., Völzke, H., Stalla, G. K., Wallaschofski, H., & Wittchen, H.-U. (2010). The Predictive Value of Different Measures of Obesity for Incident Cardiovascular Events and Mortality. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2009-1584
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