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Cited by 309

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Insulin Resistance in Adolescents with Type 1 Diabetes and Its Relationship to Cardiovascular Function

Open access
Nadeau, Kristen J., Regensteiner, Judith G., Bauer, Timothy A., Brown, Mark S., Dorosz, Jennifer L., Hull, Amber, Zeitler, Phil, Draznin, Boris, Reusch, Jane E. B.·2010·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2009-1756
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Abstract

CONTEXT: Cardiovascular disease is the major cause of death in adults with diabetes, yet little is specifically known about the effects of type 1 diabetes (T1D) on cardiovascular outcomes in youth. Although insulin resistance (IR) likely contributes to exercise and cardiovascular dysfunction in T2D, IR is not typically considered a contributor in T1D. OBJECTIVE: We hypothesized that cardiopulmonary fitness would be reduced in T1D youth in association with IR and cardiovascular dysfunction. DESIGN AND PARTICIPANTS: This cross-sectional study at an academic hospital included 12 T1D adolescents compared with 12 nondiabetic controls, similar in age, pubertal stage, activity level, and body mass index. OUTCOME MEASURES: Cardiopulmonary fitness was measured by peak oxygen consumption (VO(2)peak) and oxygen uptake kinetics (VO(2)kinetics), IR by hyperinsulinemic clamp, cardiac function by echocardiography, vascular function by venous occlusion plethysmography, intramyocellular lipid by magnetic resonance spectroscopy, and body composition by dual-energy x-ray absorptiometry. RESULTS: T1D adolescents had significantly decreased VO(2)peak, peak work rate, and insulin sensitivity compared with nondiabetic adolescents. T1D youth also had reduced vascular reactivity and evidence of diastolic dysfunction and left ventricular hypertrophy. Despite their IR and reduced cardiovascular fitness, T1D youth had paradoxically normal intramyocellular lipid, waist to hip ratio, and serum lipids and high adiponectin levels. In multivariate analysis, IR primarily, and forearm blood flow secondarily, independently predicted VO(2)peak. CONCLUSIONS: T1D youth demonstrated IR, impaired functional exercise capacity and cardiovascular dysfunction. The phenotype of IR in T1D youth was unique, suggesting a pathophysiology that is different from T2D, yet may adversely affect long-term cardiovascular outcomes.

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Metadata

Authors
Nadeau, K. J., Regensteiner, J. G., Bauer, T. A., Brown, M. S., Dorosz, J. L., Hull, A., Zeitler, P., Draznin, B., & Reusch, J. E. B.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2010-02-01
Volume
95
Issue
2
Pages
513-521
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2009-1756
OpenAlex
W2150563156
Cited by
309
References
43
FWCI
8.48
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Insulin Resistance in Adolescents with Type 1 Diabetes and Its Relationship to Cardiovascular Function. https://app.cochat.ai/papers/10.1210/jc.2009-1756
The paper
Nadeau, K. J., Regensteiner, J. G., Bauer, T. A., Brown, M. S., Dorosz, J. L., Hull, A., Zeitler, P., Draznin, B., & Reusch, J. E. B. (2010). Insulin Resistance in Adolescents with Type 1 Diabetes and Its Relationship to Cardiovascular Function. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2009-1756

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.