The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Universal Screening Versus Case Finding for Detection and Treatment of Thyroid Hormonal Dysfunction During Pregnancy
Abstract
CONTEXT: Thyroid disease during pregnancy has been associated with multiple adverse outcomes. Whether all women should be screened for thyroid disease during pregnancy is controversial. OBJECTIVE: The objective of the study was to determine whether treatment of thyroid disease during pregnancy decreases the incidence of adverse outcomes and compare the ability of universal screening vs. case finding in detecting thyroid dysfunction. DESIGN: Women in the first trimester were randomly assigned to the universal screening group or case-finding group. Women in both groups were stratified as high risk or low risk based on risk factors for thyroid disease. All women in the universal screening group, and high-risk women in the case-finding group, were immediately tested for free T(4), TSH, and thyroid peroxidase antibody. Low-risk women in the case-finding group had their sera tested postpartum. SETTING: The study was conducted at two ambulatory clinics of community hospitals in southern Italy. PATIENTS: A total of 4562 women were randomly assigned to the universal screening or case-finding group. INTERVENTION: Intervention included levothyroxine in women with a TSH above 2.5 mIU/liter in TPO antibody-positive women and antithyroid medication in women with a undetectable TSH and elevated free T(4). MAIN OUTCOME MEASURE: Total number of adverse obstetrical and neonatal outcomes was measured. RESULTS: No significant differences were seen in adverse outcomes between the case-finding and universal screening groups. Adverse outcomes were less likely to occur among low-risk women in the screening group than those in the case-finding group. CONCLUSIONS: Universal screening compared with case finding did not result in a decrease in adverse outcomes. Treatment of hypothyroidism or hyperthyroidism identified by screening a low-risk group was associated with a lower rate of adverse outcomes.
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Subclinical hypothyroidism and pregnancy outcomes
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Cited by
Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., Sullivan, S., et al. (2011) · Thyroid · doi:10.1089/thy.2011.0087 · Cited by 2,942
Self-citationAlexander, E. K., Pearce, E. N., Brent, G. A., Brown, R. S., Chen, H., Dosiou, C., Grobman, W. A., Laurberg, P., Lazarus, J. H., Mandel, S. J., et al. (2017) · Thyroid® · doi:10.1089/thy.2016.0457 · Cited by 2,731
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber, K. A. (2012) · Endocrine Practice · doi:10.4158/ep12280.gl · Cited by 1,567
Thyroid Function and Human Reproductive Health
Krassas, G. E., Poppe, K., & Glinoer, D. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0041 · Cited by 1,223
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber for the American Association, K. A. (2012) · Thyroid · doi:10.1089/thy.2012.0205 · Cited by 1,053
Cooper, D. S., & Biondi, B. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60276-6 · Cited by 1,039
Lazarus, J., Brown, R. S., Daumerie, C., Hubalewska-Dydejczyk, A., Negro, R., & Vaidya, B. (2014) · European Thyroid Journal · doi:10.1159/000362597 · Cited by 742
Self-citationvan den Boogaard, E., Vissenberg, R., Land, J. A., van Wely, M., van der Post, J. A. M., Goddijn, M., & Bisschop, P. H. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr024 · Cited by 528
A Review of the Clinical Consequences of Variation in Thyroid Function Within the Reference Range
Taylor, P. N., Razvi, S., Pearce, S. H., & Dayan, C. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1315 · Cited by 274
Treatment with thyroid hormone
Biondi, B., & Wartofsky, L. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1083 · Cited by 259
Maraka, S., Mwangi, R., McCoy, R. G., Yao, X., Sangaralingham, L. R., Singh Ospina, N. M., O’Keeffe, D. T., De Ycaza, A. E. E., Rodriguez-Gutierrez, R., Coddington, C. C., et al. (2017) · BMJ · doi:10.1136/bmj.i6865 · Cited by 249
Hypothyroidism: etiology, diagnosis, and management
Almandoz, J. P., & Gharib, H. (2012) · Medical Clinics of North America · doi:10.1016/j.mcna.2012.01.005 · Cited by 216
Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss
Bernardi, L. A., Cohen, R. N., & Stephenson, M. D. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.1975 · Cited by 90
Maraka, S., Singh Ospina, N. M., Mastorakos, G., & O’Keeffe, D. T. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00090 · Cited by 73
A 2013 Survey of Clinical Practice Patterns in the Management of Primary Hypothyroidism
Burch, H. B., Burman, K. D., Cooper, D. S., & Hennessey, J. V. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1046 · Cited by 73
Benaglia, L., Busnelli, A., Somigliana, E., Leonardi, M., Vannucchi, G., De Leo, S., Fugazzola, L., Ragni, G., & Fedele, L. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.11.003 · Cited by 46
Levothyroxine liquid solution versus tablet for replacement treatment in hypothyroid patients
Negro, R., Valcavi, R., Agrimi, D., & Toulis, K. A. (2014) · Endocrine Practice · doi:10.4158/ep13378.or · Cited by 36
Dhillon‐Smith, R. K., Boelaert, K., Jeve, Y. B., Maheshwari, A., Coomarasamy, A., & Royal College of Obstetricians and Gynaecologists (2022) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17187 · Cited by 16
Hirahara, N., Nakamura, H. M., Sasaki, S., Matsushita, A., Ohba, K., Kuroda, G., Sakai, Y., Shinkai, S., Haeno, H., Nishio, T., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0227646 · Cited by 9
Description of thyroid disorders the year before conception: a population-based study.
Tena Vivó, G., Parellada Esquius, N., Cunillera Puértolas, O., Albareda Riera, M., Isidro Albaladejo, M., & Vila Ballester, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1236505 · Cited by 6
Metadata
- Authors
- Negro, R., Schwartz, A., Gismondi, R., Tinelli, A., Mangieri, T., & Stagnaro-Green, A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2010-04-01
- Volume
- 95
- Issue
- 4
- Pages
- 1699-1707
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2154116297
- Cited by
- 377
- References
- 3
- FWCI
- 25.76
- Type
- journal article
- Language
- en
- Open access
- closed
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