The DOI matches its Crossref record; 40 of the 43 references it cites were found in a registry or an index.
Kisspeptin Resets the Hypothalamic GnRH Clock in Men
Open accessAbstract
Context: Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored. Objective: The objective of the study was to detail the effects of kisspeptin on GnRH secretion, as reflected by LH secretion, in men. Participants: Thirteen healthy adult men participated in the study. Intervention: The intervention was the administration of a single iv bolus of the C-terminal decapeptide of kisspeptin (amino acids 112–121 of the parent protein). Results: Kisspeptin induced an immediate LH pulse, regardless of the timing of the previous endogenous pulse. The kisspeptin-induced pulses were on average larger than endogenous pulses (amplitude 5.0 ± 1.0 vs. 2.1 ± 0.3 mIU/ml, P = 0.02). Comparison of the morphology of kisspeptin-induced LH pulses in healthy men with that of GnRH-induced LH pulses in men with isolated GnRH deficiency suggests that a single iv bolus of kisspeptin triggered sustained GnRH release lasting approximately 17 min. Furthermore, kisspeptin reset the GnRH pulse generator, as it not only induced an immediate LH pulse but also delayed the next endogenous pulse by an interval approximating the normal interpulse interval. Conclusions: As the first known agent capable of resetting the hypothalamic GnRH pulse generator, kisspeptin can be used as a physiological tool for studying GnRH pulse generation and opens a door to understanding the mechanisms of biological clocks in general.
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“Repetitive bolus administration of kisspeptin at a physiologic dose (30, 32) and at a frequency of 1 bolus/hour increased mean LH levels and LH pulse frequency in the entire cohort (n = 11) of hyperprolactinemic women.”
From Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans (2022) · cites this paper as [30]
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Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Diéguez, C., Millar, R. P., & Tena‐Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 843
The kisspeptin-GnRH pathway in human reproductive health and disease
Skorupskaite, K., George, J. T., & Anderson, R. A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu009 · Cited by 514
The Gonadotropin-Releasing Hormone Pulse Generator
Herbison, A. E. (2018) · Endocrinology · doi:10.1210/en.2018-00653 · Cited by 261
The endocrinology of the menstrual cycle
Barbieri, R. L. (2014) · Methods in Molecular Biology · doi:10.1007/978-1-4939-0659-8_7 · Cited by 196
Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
George, J. T., Veldhuis, J. D., Roseweir, A. K., Newton, C. L., Faccenda, E., Millar, R. P., & Anderson, R. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0089 · Cited by 186
Metadata
- Authors
- Chan, Y.-M., Butler, J. P., Pinnell, N. E., Pralong, F. P., Crowley, W. F., Ren, C., Chan, K. K., & Seminara, S. B.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- The Ohio State University (US)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2011-06-01
- Volume
- 96
- Issue
- 6
- Pages
- E908-E915
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC3100758
- OpenAlex
- W1989716417
- Cited by
- 114
- References
- 43
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 12 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 9 · 2012: 13
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- Harvard Catalyst
- National Center for Research Resources (UL1RR025758)
- NIH Clinical Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD015788, T32HD007396, R01 HD43341, R01HD043341, K24HD067388, U54HD028138)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- kisspeptin, GnRH pulse generator, GnRH secretion, luteinizing hormone secretion, GnRH deficiency, men, biological clock
- MeSH terms
- Adult, Analysis of Variance, Humans, Hypothalamus, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Periodicity, Tumor Suppressor Proteins, Kisspeptins
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