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Cited by 115Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

The DOI matches its Crossref record; 40 of the 43 references it cites were found in a registry or an index.

Kisspeptin Resets the Hypothalamic GnRH Clock in Men

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Chan, Yee-Ming, Butler, James P., Pinnell, Nancy E., Pralong, François P., Crowley, William F., Ren, Chen, Chan, Kenneth K., Seminara, Stephanie B.·2011·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2010-3046PMC PMC3100758
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Abstract

Context: Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored. Objective: The objective of the study was to detail the effects of kisspeptin on GnRH secretion, as reflected by LH secretion, in men. Participants: Thirteen healthy adult men participated in the study. Intervention: The intervention was the administration of a single iv bolus of the C-terminal decapeptide of kisspeptin (amino acids 112–121 of the parent protein). Results: Kisspeptin induced an immediate LH pulse, regardless of the timing of the previous endogenous pulse. The kisspeptin-induced pulses were on average larger than endogenous pulses (amplitude 5.0 ± 1.0 vs. 2.1 ± 0.3 mIU/ml, P = 0.02). Comparison of the morphology of kisspeptin-induced LH pulses in healthy men with that of GnRH-induced LH pulses in men with isolated GnRH deficiency suggests that a single iv bolus of kisspeptin triggered sustained GnRH release lasting approximately 17 min. Furthermore, kisspeptin reset the GnRH pulse generator, as it not only induced an immediate LH pulse but also delayed the next endogenous pulse by an interval approximating the normal interpulse interval. Conclusions: As the first known agent capable of resetting the hypothalamic GnRH pulse generator, kisspeptin can be used as a physiological tool for studying GnRH pulse generation and opens a door to understanding the mechanisms of biological clocks in general.

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Research works printed but not linked: 2

  1. Low, 2008, Neuroendocrinology, 85
  2. Ren, 2007, An LC-MS/MS method for the quantitation of metastin 45–54 (NSC 741805) and its preclinical pharmacokinetics in rats., AAPS J, 9, 2199

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Metadata

Authors
Chan, Y.-M., Butler, J. P., Pinnell, N. E., Pralong, F. P., Crowley, W. F., Ren, C., Chan, K. K., & Seminara, S. B.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
  • The Ohio State University (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2011-06-01
Volume
96
Issue
6
Pages
E908-E915
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2010-3046
PMC
PMC3100758
OpenAlex
W1989716417
Cited by
114
References
43
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 12 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 9 · 2012: 13
FWCI
14.34
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Massachusetts General Hospital
  • Harvard Catalyst
  • National Center for Research Resources (UL1RR025758)
  • NIH Clinical Center
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD015788, T32HD007396, R01 HD43341, R01HD043341, K24HD067388, U54HD028138)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
kisspeptin, GnRH pulse generator, GnRH secretion, luteinizing hormone secretion, GnRH deficiency, men, biological clock
MeSH terms
Adult, Analysis of Variance, Humans, Hypothalamus, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Periodicity, Tumor Suppressor Proteins, Kisspeptins

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