CoChat
Sign Up
Cited by 75Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryOphthalmology and Eye Disorders

Total Thyroidectomy in Patients with Amiodarone-Induced Thyrotoxicosis and Severe Left Ventricular Systolic Dysfunction

Tomisti, Luca, Materazzi, Gabriele, Bartalena, Luigi, Rossi, Giuseppe, Marchello, Angelica, Moretti, Manuela, De Napoli, Luigi, Mariotti, Rita +3 more·2012·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2012-1797
Open this paper in CoChat — free account

Abstract

CONTEXT: Patients with amiodarone-induced thyrotoxicosis (AIT) and left ventricular (LV) systolic dysfunction have a high mortality rate. Usually, medical therapy is the first choice for AIT patients, whereas the role of the thyroidectomy is unsettled. OBJECTIVE: The objective of the study was to evaluate the effect of a total thyroidectomy on cardiac function and survival of AIT patients with severe LV systolic dysfunction. DESIGN: This was a retrospective cohort study. SETTINGS: The study was conducted at a tertiary university center. PATIENTS: All AIT patients (n=24; nine patients with type 1 AIT, 15 patients with type 2 AIT) referred to the Department of Endocrinology and submitted to a total thyroidectomy at the Department of Surgery, both at the University of Pisa, during the years 1997-2010. INTERVENTION: The intervention was a total thyroidectomy. MAIN OUTCOME MEASURE: LV ejection fraction (EF) after the thyroidectomy and survival in December 2011 were measured. RESULTS: All enrolled patients had previously undergone to medical treatment for AIT, as appropriate, without achieving euthyroidism. Patients with moderate to severe LV systolic dysfunction (EF<40%, group 1, n=9) or with mild systolic dysfunction (40%≤EF≤50%, group 2, n=5) were compared with patients with normal systolic function (EF>50%, group 3, n=10). Two months after thyroidectomy, under levothyroxine replacement therapy, LVEF improved in patients with LV systolic dysfunction, particularly in those of group 1, in whom it increased from 28.2±7.2 to 38.3±6% (P=0.007). On the contrary, LVEF did not significantly change in group 3 (from 57.1±3.0 to 59.8±6.6%, P=0.242). The mean follow-up was 67±42 months. No death occurred during and 2 months after surgery. One death occurred in one patient of group 1, 30 months after the thyroidectomy, due to acute myocardial infarction. No patient had relevant complications of thyroidectomy. CONCLUSIONS: Total thyroidectomy, by rapidly restoring euthyroidism, may improve cardiac function and reduce the risk of mortality in AIT patients with severe LV dysfunction.

Integrity signals

Registry

Crossref · 10.1210/jc.2012-1797

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Tomisti, L., Materazzi, G., Bartalena, L., Rossi, G., Marchello, A., Moretti, M., De Napoli, L., Mariotti, R., Miccoli, P., Martino, E., & Bogazzi, F.
Affiliations
  • University of Pisa (IT)
  • University of Insubria (IT)
  • Istituto di Fisiologia Clinica (IT)
Corresponding author
Bogazzi, Fausto
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2012-10
Volume
97
Issue
10
Pages
3515-3521
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2012-1797
OpenAlex
W2077495157
Cited by
75
References
26
Citations by year
2026: 4 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 11 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 1
FWCI
3.08
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
Keywords
amiodarone-induced thyrotoxicosis, total thyroidectomy, left ventricular systolic dysfunction, left ventricular ejection fraction, levothyroxine replacement, cardiac function recovery, survival, thyroidectomy complications, myocardial infarction mortality
MeSH terms
Aged, Amiodarone, Anti-Arrhythmia Agents, Female, Heart Diseases, Humans, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Risk Factors, Severity of Illness Index, Stroke Volume, Systole, Thyroidectomy, Thyrotoxicosis, Vasodilator Agents, Ventricular Dysfunction, Left

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review