Natural history of asymptomatic left ventricular systolic dysfunction in the community

Wang, Thomas J.; Evans, Jane C.; Benjamin, Emelia J.; Levy, Daniel; LeRoy, Elizabeth C.; Vasan, Ramachandran S.

doi:10.1161/01.cir.0000085166.44904.79

Cited by 633Cardiovascular Function and Risk FactorsHeart Failure Treatment and ManagementCardiomyopathy and Myosin Studies

Natural history of asymptomatic left ventricular systolic dysfunction in the community

Wang, Thomas J., Evans, Jane C., Benjamin, Emelia J., Levy, Daniel, LeRoy, Elizabeth C., Vasan, Ramachandran S.·2003·Circulation

DOI 10.1161/01.cir.0000085166.44904.79

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Abstract

Background— Information is limited regarding the rates of progression to congestive heart failure (CHF) and death in individuals with asymptomatic left ventricular systolic dysfunction (ALVD). We sought to characterize the natural history of ALVD, by studying unselected individuals with this condition in the community. Methods and Results— We studied 4257 participants (1860 men) from the Framingham Study who underwent routine echocardiography. The prevalence of ALVD (visually estimated ejection fraction [EF]≤50% without a history of CHF) was 6.0% in men and 0.8% in women. During up to 12 years of follow-up, rates of CHF among subjects with normal left ventricular systolic function (EF >50%, n=4128) and ALVD (n=129) were 0.7 and 5.8 per 100 person-years, respectively. After adjustment for cardiovascular disease risk factors, ALVD was associated with a hazards ratio (HR) for CHF of 4.7 (95% CI 2.7 to 8.1), compared with individuals without ALVD. An elevated risk of CHF after ALVD was observed even in individuals without prior myocardial infarction or valvular disease, with an adjusted HR of 6.5 (CI 3.1 to 13.5). Mild ALVD (EF 40% to 50%, n=78) and moderate-to-severe ALVD (EF <40%, n=51) were associated with adjusted HRs for CHF of 3.3 (CI 1.7 to 6.6) and 7.8 (CI 3.9 to 15.6), respectively. ALVD was also associated with an increased mortality risk (adjusted HR 1.6, CI 1.1 to 2.4). The median survival of ALVD subjects was 7.1 years. Conclusion— Individuals with ALVD in the community are at high risk of CHF and death, even when only mild impairment of EF is present. Additional studies are needed to define optimal therapy for mild ALVD.

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Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
The SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029 · see citing works
Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
Moss, A. J., Zaręba, W., Hall, W. J., Klein, H., Wilber, D. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Brown, M. W., & Andrews, M. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013474 · Cited by 6,885 · see citing works
Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction: Results of the Survival and Ventricular Enlargement Trial
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911 · see citing works
Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions
(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725 · see citing works
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652 · see citing works
Burden of Systolic and Diastolic Ventricular Dysfunction in the Community
Redfield, M. M., Jacobsen, S. J., Burnett, J. C. J., Mahoney, D. W., Bailey, K. R., & Rodeheffer, R. J. (2003) · JAMA · doi:10.1001/jama.289.2.194 · Cited by 2,989 · see citing works
Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.
Pfeffer, M. A., & D, E. B. M. (1990) · Circulation · doi:10.1161/01.cir.81.4.1161 · Cited by 2,873 · see citing works
Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling
Cohn, J. N., Ferrari, R., & Sharpe, N. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00630-0 · Cited by 2,591 · see citing works
Long-term trends in the incidence of and survival with heart failure
Levy, D., Kenchaiah, S., Larson, M. G., Benjamin, E. J., Kupka, M. J., Ho, K. K. L., Murabito, J. M., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020265 · Cited by 2,152 · see citing works
Self-citation
Epidemiological approaches to heart disease: the Framingham study
Dawber, T. R., Meadors, G. F., & Moore, F. E. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.3.279 · Cited by 2,148 · see citing works
ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary
Hunt, S. A., Baker, D. W., Chin, M. H., Cinquegrani, M. P., Feldman, A. M., Francis, G. S., Ganiats, T. G., Goldstein, S., Gregoratos, G., Jessup, M. L., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01683-7 · Cited by 1,909 · see citing works
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
Kannel, W. B., Feinleib, M., McNAMARA, P. M., Garrison, R. J., & Castelli, W. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112813 · Cited by 1,635 · see citing works
Congestive Heart Failure in the Community
Senni, M., Tribouilloy, C. M., Rodeheffer, R. J., Jacobsen, S. J., Evans, J. M., Bailey, K. R., & Redfield, M. M. (1998) · Circulation · doi:10.1161/01.cir.98.21.2282 · Cited by 1,084 · see citing works
Self-citation
Mechanisms and Models in Heart Failure
Mann, D. L. (1999) · Circulation · doi:10.1161/01.cir.100.9.999 · Cited by 761 · see citing works
Prevalence of left-ventricular systolic dysfunction and heart failure in the Echocardiographic Heart of England Screening study: a population based study
Davies, M., Hobbs, F., Davis, R., Kenkre, J., Roalfe, A., Hare, R., Wosornu, D., & Lancashire, R. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05620-3 · Cited by 657 · see citing works
Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population
McDonagh, T. A., Morrison, C., Lawrence, A., Ford, I., Tunstall-Pedoe, H., McMurray, J. J. V., & Dargie, H. J. (1997) · The Lancet · doi:10.1016/s0140-6736(97)03033-x · Cited by 631 · see citing works
Outcome of Congestive Heart Failure in Elderly Persons: Influence of Left Ventricular Systolic Function: The Cardiovascular Health Study
Gottdiener, J. S., McClelland, R. L., Marshall, R., Shemanski, L., Furberg, C. D., Kitzman, D. W., Cushman, M., Polak, J. F., Gardin, J. M., Gersh, B. J., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-8-200210150-00006 · Cited by 476 · see citing works
ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary
Hunt, S. A., Baker, D. W., Chin, M. H., Cinquegrani, M. P., Feldman, A. M., Francis, G. S., Ganiats, T. G., Goldstein, S., Gregoratos, G., Jessup, M. L., et al. (2002) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(01)00776-8 · Cited by 285 · see citing works
Comparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions
van Royen, N., Jaffe, C. C., Krumholz, H. M., Johnson, K. M., Lynch, P. J., Natale, D., Atkinson, P., Demon, P., & Wackers, F. J. T. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89179-5 · Cited by 268 · see citing works
Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population
McDonagh, T. A., Cunningham, A. D., Morrison, C. E., McMurray, J. J. V., Ford, I., Morton, J. J., & Dargie, H. J. (2001) · Heart · doi:10.1136/heart.86.1.21 · Cited by 261 · see citing works
Superiority of visual versus computerized echocardiographic estimation of radionuclide left ventricular ejection fraction
Amico, A. F., Lichtenberg, G. S., Reisner, S. A., et al. (1989) · American Heart Journal · doi:10.1016/0002-8703(89)90018-5 · Cited by 253 · see citing works
Comparison of Different Echocardiographic Methods With Radionuclide Imaging for Measuring Left Ventricular Ejection Fraction During Acute Myocardial Infarction Treated by Thrombolytic Therapy
Jensen‐Urstad, K., Bouvier, F., Höjer, J., Ruiz, H., Hulting, J., Samad, B. A., Thorstrand, C., & Jensen‐Urstad, M. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00964-8 · Cited by 181 · see citing works
Should we screen for asymptomatic left ventricular dysfunction to prevent heart failure?
McMurray, J. J. V., McDonagh, T., Davie, A. P., Cleland, J. G. F., Francis, C. M., & Morrison, C. E. (1998) · European Heart Journal · doi:10.1093/eurheartj/19.6.842 · Cited by 151 · see citing works
Prognostic implications of subclinical left ventricular dilatation and systolic dysfunction in men free of overt cardiovascular disease (the framingham heart study)
Lauer, M. S., Evans, J. C., & Levy, D. A. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90052-z · Cited by 141 · see citing works
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Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,618 · see citing works
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429 · see citing works
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866 · see citing works
ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008
Dickstein, K., Authors Task Force Members, Solal, A. C., Filippatos, G. S., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.08.005 · Cited by 3,515 · see citing works
Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Bild, D. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf113 · Cited by 3,942 · see citing works
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862 · see citing works
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
Authors Task Force Members, Dickstein, K., Solal, A. C., Filippatos, G., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn309 · Cited by 2,688 · see citing works
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001063 · Cited by 4,922 · see citing works
Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005)
Swedberg, K. B., Cleland, J. G. F., Dargie, H., Drexler, H., Folláth, F., Michel Komajda, N., Tavazzi, L., Smiseth, O. A., Gavazzi, A., Haverich, A., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi204 · Cited by 2,243 · see citing works
“associated with high mortality.(19) It is important when diagnosed and treatment is available, and the condition is therefore included in these Guidelines.”
Background
Clinical epidemiology of heart failure
Mosterd, A., & Hoes, A. W. (2007) · Heart · doi:10.1136/hrt.2003.025270 · Cited by 1,921 · see citing works
The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective
Mahmood, S. S., Levy, D., Vasan, R. S., & Wang, T. J. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61752-3 · Cited by 1,622 · see citing works
Self-citation
Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial
Fox, K., Ford, I., Steg, P. G., Tendera, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61170-8 · Cited by 1,099 · see citing works
Dilated cardiomyopathy: the complexity of a diverse genetic architecture
Hershberger, R. E., Hedges, D. J., & Morales, A. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.105 · Cited by 1,023 · see citing works
Artificial intelligence-enhanced electrocardiography in cardiovascular disease management
Siontis, K. C., Noseworthy, P. A., Attia, Z. I., & Friedman, P. A. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00503-2 · Cited by 914 · see citing works
Atrial Fibrillation Begets Heart Failure and Vice Versa
Santhanakrishnan, R., Wang, N., Larson, M. G., Magnani, J. W., McManus, D. D., Lubitz, S. A., Ellinor, P. T., Cheng, S. C., Vasan, R. S., Lee, D. S., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.018614 · Cited by 874 · see citing works
Self-citation
Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab
Sawaya, H., Sebag, I. A., Plana, J. C., Januzzi, J. L., Ky, B., Tan, T. C., Cohen, V., Banchs, J. A., Carver, J. R., Wiegers, S. E., et al. (2012) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.112.973321 · Cited by 813 · see citing works
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Zhu, H., Tannous, P., Johnstone, J. L., Kong, Y., Shelton, J. M., Richardson, J. A., Le, V., Levine, B., Rothermel, B. A., & Hill, J. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci27523 · Cited by 765 · see citing works
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Ezekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676 · see citing works
Type 2 diabetes mellitus and heart failure: a scientific statement from the American Heart Association and the Heart Failure Society of America: this statement does not represent an update of the 2017 ACC/AHA/HFSA heart failure guideline update
Dunlay, S. M., Givertz, M. M., Aguilar, D., Allen, L. A., Chan, M., Desai, A. S., Deswal, A., Dickson, V. V., Kosiborod, M. N., Lekavich, C. L., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000691 · Cited by 639 · see citing works
Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography
Jenkins, C., Bricknell, K., Hanekom, L., & Marwick, T. H. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.05.050 · Cited by 597 · see citing works
Prevention of Heart Failure
Schocken, D. D., Benjamin, E. J., Fonarow, G. C., Krumholz, H. M., Levy, D. A., Mensah, G. A., Narula, J., Stuart‐Shor, E., Young, J. B., & Hong, Y. (2008) · Circulation · doi:10.1161/circulationaha.107.188965 · Cited by 548 · see citing works
Self-citation
Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention
Henriksen, P. A. (2017) · Heart · doi:10.1136/heartjnl-2017-312103 · Cited by 539 · see citing works
Prevalence and Prognostic Significance of Heart Failure Stages
Ammar, K. A., Jacobsen, S. J., Mahoney, D. W., Kors, J. A., Redfield, M. M., Burnett, J. C. J., & Rodeheffer, R. J. (2007) · Circulation · doi:10.1161/circulationaha.106.666818 · Cited by 524 · see citing works
“Coronary artery disease 0 42 (9) 116 (17) 83 (35) 50 (26) 33 (75) 3 (60) 244”
Cohort Profile: The Framingham Heart Study (FHS): overview of milestones in cardiovascular epidemiology
Tsao, C. W., & Vasan, R. S. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv337 · Cited by 457 · see citing works
Self-citation
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P. P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González‐Juanatey, J. R., Harjola, V., Jankowska, E. A., et al. (2016) · Kardiologia Polska · doi:10.5603/kp.2016.0141 · Cited by 450 · see citing works
Artificial intelligence–enabled electrocardiograms for identification of patients with low ejection fraction: a pragmatic, randomized clinical trial
Yao, X., Rushlow, D. R., Inselman, J. W., McCoy, R. G., Thacher, T. D., Behnken, E. M., Bernard, M. E., Rosas, S. L., Akfaly, A., Misra, A., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01335-4 · Cited by 424 · see citing works
Biomarkers and diagnostics in heart failure
Gaggin, H. K., & Januzzi, J. L. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.12.014 · Cited by 423 · see citing works
Ejection Fraction Pros and Cons
Marwick, T. H. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2162 · Cited by 318 · see citing works
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Lam, C. S. P., Lyass, A., Kraigher‐Krainer, E., Massaro, J. M., Lee, D. S., Ho, J. E., Levy, D. A., Redfield, M. M., Pieske, B. M., Benjamin, E. J., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.979203 · Cited by 315 · see citing works
Self-citation
Assessment of Conventional Cardiovascular Risk Factors and Multiple Biomarkers for the Prediction of Incident Heart Failure and Atrial Fibrillation
Smith, J. G., Newton‐Cheh, C., Almgren, P., Struck, J., Morgenthaler, N. G., Bergmann, A., Platonov, P. G., Hedblad, B., Engström, G., Wang, T. J., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.05.049 · Cited by 311 · see citing works
Self-citation
70-year legacy of the Framingham Heart Study
Andersson, C., Johnson, A. D., Benjamin, E. J., Levy, D., & Vasan, R. S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0202-5 · Cited by 305 · see citing works
Self-citation
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Crisafulli, E., Costi, S., Luppi, F., Cirelli, G., Cilione, C., Coletti, O., Fabbri, L. M., & Clini, E. M. (2008) · Thorax · doi:10.1136/thx.2007.086371 · Cited by 271 · see citing works
Plasma Brain Natriuretic Peptide to Detect Preclinical Ventricular Systolic or Diastolic Dysfunction
Redfield, M. M., Rodeheffer, R. J., Jacobsen, S. J., Mahoney, D. W., Bailey, K. R., & Burnett, J. C. J. (2004) · Circulation · doi:10.1161/01.cir.0000130845.38133.8f · Cited by 260 · see citing works
2018 European Thyroid Association (ETA) Guidelines for the Management of Amiodarone-Associated Thyroid Dysfunction
Bartalena, L., Bogazzi, F., Chiovato, L., Hubalewska-Dydejczyk, A., Links, T. P., & Vanderpump, M. (2018) · European Thyroid Journal · doi:10.1159/000486957 · Cited by 264 · see citing works
Epidemiology of the inherited cardiomyopathies
McKenna, W. J., & Judge, D. P. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0428-2 · Cited by 261 · see citing works
Prevalence and Prognostic Value of Subclinical Left Ventricular Systolic Dysfunction by Global Longitudinal Strain in a Community-Based Cohort
Russo, C. A., Jin, Z., Elkind, M. S. V., Rundek, T., Homma, S., Sacco, R. L., & Tullio, M. R. D. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.154 · Cited by 252 · see citing works
Women Have Higher Left Ventricular Ejection Fractions Than Men Independent of Differences in Left Ventricular Volume
Chung, A. K., Das, S. R., Leonard, D. S., Peshock, R. M., Kazi, F., Abdullah, S. M., Canham, R. M., Levine, B. D., & Drazner, M. H. (2006) · Circulation · doi:10.1161/circulationaha.105.574400 · Cited by 250 · see citing works
Left atrial structure and function and clinical outcomes in the general population
Gupta, S., Matulevicius, S. A., Ayers, C. R., Berry, J. D., Patel, P. C., Markham, D. W., Levine, B. D., Chin, K., de Lemos, J. A., Peshock, R. M., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs188 · Cited by 235 · see citing works
Genetic Variants Associated With Cardiac Structure and Function
Vasan, R. S., Glazer, N. L., Felix, J. F., Lieb, W., Wild, P. S., Felix, S. B., Watzinger, N., Larson, M. G., Smith, N. L., Dehghan, A., et al. (2009) · JAMA · doi:10.1001/jama.2009.978-a · Cited by 222 · see citing works
Self-citation
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Stewart, S., Wilkinson, D., Hansen, C. A., Vaghela, V., Mvungi, R., McMurray, J. J. V., & Sliwa, K. S. (2008) · Circulation · doi:10.1161/circulationaha.108.786244 · Cited by 220 · see citing works
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Background
Cardiac Outcomes in Adult Survivors of Childhood Cancer Exposed to Cardiotoxic Therapy
Mulrooney, D. A., Armstrong, G. T., Huang, S., Ness, K. K., Ehrhardt, M. J., Joshi, V. M., Plana, J. C., Soliman, E. Z., Green, D. M., Srivastava, D. K., et al. (2016) · Annals of Internal Medicine · doi:10.7326/m15-0424 · Cited by 220 · see citing works
“The risk for heart failure among persons with untreated systolic dysfunction is significant (29) and has been reported to be as high as 9% per year, with a 3-year mortality rate of 16% (30).”
The Middle Child in Heart Failure: Heart Failure with Mid-Range Ejection Fraction (40–50%)
Lam, C. S. P., & Solomon, S. D. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.159 · Cited by 217 · see citing works
Risk Factors for Ischaemic Stroke
Allen, C., & Bayraktutan, U. (2008) · International Journal of Stroke · doi:10.1111/j.1747-4949.2008.00187.x · Cited by 212 · see citing works
Risk Factors for Heart Failure
Lawson, C. A., Zaccardi, F., Squire, I. B., Okhai, H., Davies, M. J., Huang, W., Mamas, M. A., Lam, C. S. P., Khunti, K., & Kadam, U. T. (2020) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006472 · Cited by 205 · see citing works
Sarcopenia in Heart Failure: A Systematic Review and Meta-Analysis
Zhang, Y., Zhang, J., Ni, W., Yuan, X., Zhang, H., Li, P., Xu, J., & Zhao, Z. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13255 · Cited by 202 · see citing works
“Historically, patients with HF have been categorized based on their LVEF, which is important in HF management because LVEF has been shown to be predictive of adverse outcomes, even in the absence of symptomatic HF.(35,36) Therefore, the grading of LVEF in the predictive role of sarcopenia in patients with HF may be a…”
Background
Long-Term Anabolic-Androgenic Steroid Use Is Associated With Left Ventricular Dysfunction
Baggish, A. L., Weiner, R. B., Kanayama, G., Hudson, J. I., Picard, M. H., Hutter, A. M., & Pope, H. G. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.931063 · Cited by 193 · see citing works
Heart Failure With Mid-Range (Borderline) Ejection Fraction
Hsu, J. J., Ziaeian, B., & Fonarow, G. C. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2017.06.013 · Cited by 184 · see citing works
Analysis of Regional Left Ventricular Function by Cineventriculography, Cardiac Magnetic Resonance Imaging, and Unenhanced and Contrast-Enhanced Echocardiography
Hoffmann, R., von Bardeleben, S., Kasprzak, J. D., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.012 · Cited by 182 · see citing works
Comparison of Two- and Three-Dimensional Echocardiography With Sequential Magnetic Resonance Imaging for Evaluating Left Ventricular Volume and Ejection Fraction Over Time in Patients With Healed Myocardial Infarction
Jenkins, C., Bricknell, K., Chan, J. H., et al. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.08.026 · Cited by 177 · see citing works
Left Ventricular Systolic Dysfunction and the Risk of Ischemic Stroke in a Multiethnic Population
Hays, A. G., Sacco, R. L., Rundek, T., Sciacca, R. R., Jin, Z., Liu, R., Homma, S., & Tullio, M. R. D. (2006) · Stroke · doi:10.1161/01.str.0000227121.34717.40 · Cited by 173 · see citing works
Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme
Petersen, E. L., Goßling, A., Adam, G., Aepfelbacher, M., Behrendt, C., Çavuş, E., Cheng, B., Fischer, N., Gallinat, J., Kühn, S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab914 · Cited by 164 · see citing works
Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury
Neilan, T. G. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl013 · Cited by 164 · see citing works
Stage B Heart Failure
Goldberg, L. R., & Jessup, M. L. (2006) · Circulation · doi:10.1161/circulationaha.105.600437 · Cited by 161 · see citing works
Heart Failure in Patients with Chronic Kidney Disease: A Systematic Integrative Review
Segall, L., Nistor, I., & Covic, A. C. (2014) · BioMed Research International · doi:10.1155/2014/937398 · Cited by 160 · see citing works
“All valves must be evaluated for anatomic changes, flow abnormalities, and dysfunctions, such as valvular regurgitation.”
Background
Heart failure
Krum, H., & Abraham, W. T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60236-1 · Cited by 158 · see citing works
Metoprolol Reverses Left Ventricular Remodeling in Patients With Asymptomatic Systolic Dysfunction: The REversal of VEntricular Remodeling with Toprol-XL (REVERT) Trial
Colucci, W. S., Kolias, T. J., Adams, K. F., Armstrong, W. F., Ghali, J. K., Gottlieb, S. S., Greenberg, B., Klibaner, M. I., Kukin, M. L., & Sugg, J. E. (2007) · Circulation · doi:10.1161/circulationaha.106.666016 · Cited by 181 · see citing works
“Treatment Regimen Patients who met inclusion/exclusion criteria were randomized in a 1:1:1 ratio to a 52-week treatment with metoprolol succinate extended-release tablets (metoprolol succinate, TOPROL-XL, AstraZeneca, Wilmington, Del) or placebo as follows: (1) metoprolol succinate 200 mg/d (high-dose group); (2) meto…”
Clinical Applications of Strain Echocardiography: A Clinical Consensus Statement From the American Society of Echocardiography Developed in Collaboration With the European Association of Cardiovascular Imaging of the European Society of Cardiology
Thomas, J. D., Edvardsen, T., Abraham, T. P., Appadurai, V., Badano, L. P., Banchs, J. A., Cho, G., Cosyns, B., Delgado, V., Donal, E., et al. (2025) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2025.07.007 · Cited by 170 · see citing works
Assessing the Risk of Progression From Asymptomatic Left Ventricular Dysfunction to Overt Heart Failure
Echouffo-Tcheugui, J. B., Erqou, S. A., Butler, J., Yancy, C. W., & Fonarow, G. C. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.09.015 · Cited by 154 · see citing works
The natriuretic peptides in cardiovascular medicine
Munagala, V. K., BURNETTJR, J., & Redfield, M. M. (2004) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2004.07.002 · Cited by 151 · see citing works
Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images
Sangha, V., Nargesi, A. A., Dhingra, L. S., Khunte, A., Mortazavi, B. J., Ribeiro, A. H., Banina, E., Adeola, O., Garg, N., Brandt, C. A., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.062646 · Cited by 150 · see citing works
“Further sensitivity analyses demonstrated consistent model performance on ECGs: (1) without a prolonged PR interval (AUROC, 0.”
Method
Type 2 diabetes mellitus and heart failure, a scientific statement from the American Heart Association and Heart Failure Society of America
Dunlay, S. M., Givertz, M. M., Aguilar, D., Allen, L. A., Chan, M., Desai, A. S., Deswal, A., Dickson, V. V., Kosiborod, M. N., Lekavich, C. L., et al. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.05.007 · Cited by 145 · see citing works
Prognostic value of myocardial circumferential strain for incident heart failure and cardiovascular events in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis
Choi, E., Rosen, B. D., Fernandes, V., Yan, R. T., Yoneyama, K., Donekal, S., Opdahl, A., de Almeida, A. L. C., Wu, C. O., Gomes, A. S., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht133 · Cited by 141 · see citing works
Advances in Multimodality Imaging in Cardio-Oncology
Baldassarre, L. A., Ganatra, S., Lopez‐Mattei, J., Yang, E. H., Zaha, V. G., Wong, T. C., Ayoub, C., DeCara, J. M., Dent, S. F., Deswal, A. M., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.08.743 · Cited by 137 · see citing works
Predictors and Outcomes of Heart Failure with Mid-Range Ejection Fraction
Bhambhani, V., Kizer, J. R., Lima, J. A. C., van der Harst, P., Bahrami, H., Nayor, M. G., de Filippi, C. R., Enserro, D. M., Blaha, M. J., Cushman, M., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.1091 · Cited by 134 · see citing works
Self-citation
Risk factors for heart failure
Kenchaiah, S., Narula, J., & Vasan, R. S. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.016 · Cited by 134 · see citing works
“Natriuretic peptides also are correlated with increased LV mass and systolic dysfunction [213–215], known precursors of HF [139,140].”
BackgroundSelf-citation
CD36 Expression Contributes to Age-Induced Cardiomyopathy in Mice
Koonen, D. P. Y., Febbraio, M., Bonnet, S., Nagendran, J., Young, M. E., Michelakis, E. D., & Dyck, J. R. B. (2007) · Circulation · doi:10.1161/circulationaha.107.712901 · Cited by 134 · see citing works
Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice
Dolinsky, V. W., Rogan, K. J., Sung, M. M., Zordoky, B. N., Haykowsky, M. J., Young, M. E., Jones, L. W., & Dyck, J. R. B. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00044.2013 · Cited by 133 · see citing works
Left Ventricular Dysfunction in Patients Receiving Cardiotoxic Cancer Therapies
Yoon, G., Telli, M. L., Kao, D. P., Matsuda, K. Y., Carlson, R. W., & Witteles, R. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.07.023 · Cited by 132 · see citing works
Development of heart failure in recent hypertension trials
Tocci, G., Sciarretta, S., & Volpe, M. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282fe1d3d · Cited by 130 · see citing works
Abnormal electrocardiographic findings in athletes: recognising changes suggestive of cardiomyopathy
Drezner, J. A., Ashley, E. A., Baggish, A. L., Börjesson, M., Corrado, D., Owens, D. S., Patel, A. A., Pelliccia, A., Vetter, V. L., Ackerman, M. J., et al. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-092069 · Cited by 129 · see citing works
Biomarkers for heart failure: small molecules with high clinical relevance
Magnussen, C., & Blankenberg, S. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12756 · Cited by 130 · see citing works
Myocardial performance index, a Doppler-derived index of global left ventricular function, predicts congestive heart failure in elderly men
Ärnlöv, J., Ingelsson, E., Risérus, U., Andrén, B., & LIND, L. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.10.021 · Cited by 129 · see citing works
Functional measurements based on feature tracking of cine magnetic resonance images identify left ventricular segments with myocardial scar
Maret, E., Tödt, T., Brudin, L. H., Nylander, E., Swahn, E., Ohlsson, J. L., & Engvall, J. E. (2009) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-7-53 · Cited by 128 · see citing works
“Unless compensated for by hyperkinetic wall motion in remote areas, the physiological effect of a WMA is a reduction in the left ventricular ejection fraction (LVEF) which is closely related to prognosis in chronic coronary artery disease [7-11].”
Management of chronic heart failure in the older population.
Azad, N., & Lemay, G. (2014) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2014.04.008 · Cited by 161 · see citing works
Meta-Analysis of the Prognostic Role of Late Gadolinium Enhancement and Global Systolic Impairment in Left Ventricular Noncompaction
Grigoratos, C., Barison, A., Ivanov, A., et al. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2018.12.029 · Cited by 119 · see citing works
Left Ventricular Ejection Fraction
Fonarow, G. C., & Hsu, J. J. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.03.021 · Cited by 117 · see citing works
The Influence of Rheumatoid Arthritis Disease Characteristics on Heart Failure
Myasoedova, E., Crowson, C. S., Nicola, P., Kremers, H. M., Davis, J. M., Roger, V. L., Therneau, T. M., & Gabriel, S. E. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.100979 · Cited by 116 · see citing works
“Medications were modeled 2 ways: (1) as use at any time where the time-dependent covariates reflected medication start dates only; and (2) as current use where the time-dependent covariates represented the time each patient was taking each medication, beginning at start date and ending at stop date for each medication.”
Method
Prevalence of Preclinical and Clinical Heart Failure in the Elderly. A Population-Based Study in Central Italy
Mureddu, G. F., Agabiti, N., Rizzello, V., Forastiere, F., Latini, R., Cesaroni, G., Masson, S., Cacciatore, G., Colivicchi, F., Uguccioni, M., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs052 · Cited by 116 · see citing works
Incremental Prognostic Value of Myocardial Fibrosis in Patients With Non–Ischemic Cardiomyopathy Without Congestive Heart Failure
Masci, P. G., Doulaptsis, C., Bertella, E., Torto, A. D., Symons, R., Pontone, G., Barison, A., Droogné, W., Andreini, D., Lorenzoni, V., et al. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000996 · Cited by 113 · see citing works
Prognosis of Individuals With Asymptomatic Left Ventricular Systolic Dysfunction in the Multi-Ethnic Study of Atherosclerosis (MESA)
Yeboah, J., Rodríguez, C. J., Stacey, B. R., Lima, J. A. C., Liu, S., Carr, J. J., Hundley, W. G., & Herrington, D. M. (2012) · Circulation · doi:10.1161/circulationaha.112.112201 · Cited by 113 · see citing works
Guías de Práctica Clínica sobre el diagnóstico y tratamiento de la insuficiencia cardíaca crónica. Versión resumida (actualización 2005)
de Diagnóstico, G. D. T., & de Cardiología, T. D. L. I. C. C. D. L. S. E. (2005) · Revista Española de Cardiología · doi:10.1157/13078554 · Cited by 113 · see citing works
The Prognostic Value of Non-Linear Analysis of Heart Rate Variability in Patients with Congestive Heart Failure—A Pilot Study of Multiscale Entropy
Ho, Y., Lin, C., Lin, Y., & Lo, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018699 · Cited by 112 · see citing works
“Congestive heart failure (CHF) remains to be one of the major cardiovascular disorders in the world”
Background
The Epidemiology of Congestive Heart Failure: Contributions from the Framingham Heart Study
Mahmood, S., & Wang, T. J. (2013) · Global Heart · doi:10.1016/j.gheart.2012.12.006 · Cited by 112 · see citing works
Self-citation
Trastuzumab-induced cardiotoxicity in early breast cancer patients: a retrospective study of possible risk and protective factors
Farolfi, A., Melegari, E., Aquilina, M., et al. (2013) · Heart · doi:10.1136/heartjnl-2012-303151 · Cited by 111 · see citing works
Left Ventricular Function Assessed by Two-Dimensional Speckle Tracking Echocardiography in Long-Term Survivors of Hodgkin's Lymphoma Treated by Mediastinal Radiotherapy With or Without Anthracycline Therapy
Tsai, H.-R., Gjesdal, O., Wethal, T., et al. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.09.048 · Cited by 110 · see citing works
Arterial Stiffness Is Associated With Regional Ventricular Systolic and Diastolic Dysfunction
Fernandes, V., Polak, J. F., Cheng, S. C., Rosen, B. D., Carvalho, B. S., Nasir, K., McClelland, R. L., Hundley, G. W., Pearson, G., O’Leary, D. H., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.156950 · Cited by 107 · see citing works
Elevated Levels of Oxidative DNA Damage in Serum and Myocardium of Patients With Heart Failure
Kono, Y., Nakamura, K., Kimura, H., Nishii, N., Watanabe, A., Banba, K., Miura, A., Nagase, S., Sakuragi, S., KUSANO, K. F., et al. (2006) · Circulation Journal · doi:10.1253/circj.70.1001 · Cited by 105 · see citing works
Cardiac Surveillance Guidelines for Trastuzumab-Containing Therapy in Early-Stage Breast Cancer: Getting to the Heart of the Matter
Dang, C. T., Yu, A. F., Jones, L. W., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.5515 · Cited by 104 · see citing works
“Yet, a notable 62% of patients with asymptomatic LVEF decline who developed CHF had a history of baseline or interval myocardial infarction.(14) However, in the oncology setting, the association between asymptomatic LVEF decline and CHF is”
Background
Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction using natriuretic peptides: Results from the Dallas Heart Study
de Lemos, J. A., McGuire, D. K., Khera, A., Das, S. R., Murphy, S. A., Omland, T., & Drazner, M. H. (2009) · American Heart Journal · doi:10.1016/j.ahj.2008.12.017 · Cited by 103 · see citing works
“0 25 (3-65) 94 (91-96) 7 (1-24) 98 (97-99) Black 688 8.”
Influential
Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study
Sundström, J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.01.008 · Cited by 103 · see citing works
Association of Cardiorespiratory Fitness With Left Ventricular Remodeling and Diastolic Function
Brinker, S., Pandey, A., Ayers, C. R., Barlow, C. E., DeFina, L. F., Willis, B. L., Radford, N. B., Farzaneh‐Far, R., de Lemos, J. A., Drazner, M. H., et al. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.01.004 · Cited by 101 · see citing works
Subclinical Atherosclerosis and Incipient Regional Myocardial Dysfunction in Asymptomatic Individuals
Fernandes, V., Polak, J. F., Edvardsen, T., Carvalho, B. S., Gomes, A. S., Bluemke, D. A., Nasir, K., O’Leary, D. H., & Lima, J. A. C. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.12.075 · Cited by 99 · see citing works
“Because asymptomatic global LV dysfunction is considered to be a subclinical marker of heart failure because of its frequent progression to symptomatic CHF ( 25 ,26), the IMT-related alterations of regional LV function reported in this study could represent the earliest signs of myocardial functional impairment in the…”
Background
Phosphinic peptides as zinc metalloproteinase inhibitors
Dive, V., Georgiadis, D., Matziari, M., Makaritis, A., Beau, F., Cuniasse, P., & Yiotakis, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4050-y · Cited by 100 · see citing works
Long-Term Survival of Incident Hemodialysis Patients Who Are Hospitalized for Congestive Heart Failure, Pulmonary Edema, or Fluid Overload
Banerjee, D., Ma, J. Z., Collins, A. J., et al. (2007) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01110307 · Cited by 99 · see citing works
A Comparison between QLAB and TomTec Full Volume Reconstruction for Real Time Three‐Dimensional Echocardiographic Quantification of Left Ventricular Volumes
Soliman, O. I. I., Krenning, B. J., Geleijnse, M. L., Nemes, A., van Geuns, R., Baks, T., Anwar, A. M., Galema, T. W., Vletter, W. B., & ten Cate, F. J. (2007) · Echocardiography · doi:10.1111/j.1540-8175.2007.00502.x · Cited by 97 · see citing works
Clinical prediction of incident heart failure risk: a systematic review and meta-analysis
Yang, H., Negishi, K., Otáhal, P., & Marwick, T. H. (2015) · Open Heart · doi:10.1136/openhrt-2014-000222 · Cited by 98 · see citing works
“The original intention of the analysis was to develop a risk score using the available clinical variables.”
Method
ECG AI-Guided Screening for Low Ejection Fraction (EAGLE): Rationale and design of a pragmatic cluster randomized trial
Yao, X., McCoy, R. G., Friedman, P. A., Shah, N. D., Barry, B. A., Behnken, E. M., Inselman, J. W., Attia, Z. I., & Noseworthy, P. A. (2020) · American Heart Journal · doi:10.1016/j.ahj.2019.10.007 · Cited by 98 · see citing works
Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)
Wong, C. M., Hawkins, N. M., Petrie, M. C., Jhund, P. S., Gardner, R. S., Ariti, C. A., Poppe, K., Earle, N. J., WHALLEY, G. A., Squire, I. B., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu216 · Cited by 98 · see citing works
Dabigatran Compared with Warfarin in Patients with Atrial Fibrillation and Symptomatic Heart Failure: A Subgroup Analysis of the RE-LY Trial
Ferreira, J., Ezekowitz, M. D., Connolly, S. J., Brueckmann, M., Fraessdorf, M., Reilly, P. A., Yusuf, S., & Wallentin, L. C. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft111 · Cited by 97 · see citing works
Left Ventricular Assist Devices Are Underutilized
Miller, L. W. (2011) · Circulation · doi:10.1161/circulationaha.110.958991 · Cited by 97 · see citing works

Prognosis of patients with asymptomatic left ventricular dysfunction in kexuecheng community of mianyang city
Yu, P. (2008) · Xinxueguan kangfu yixue zazhi
Prognosis of Individuals With Asymptomatic Left Ventricular Systolic Dysfunction in the Multi-Ethnic Study of Atherosclerosis (MESA)
Yeboah, J., Rodríguez, C. J., Stacey, B. R., Lima, J. A. C., Liu, S., Carr, J. J., Hundley, W. G., & Herrington, D. M. (2012) · Circulation · doi:10.1161/circulationaha.112.112201 · Cited by 113 · see citing works
Comparison of Characteristics and Outcomes of Asymptomatic Versus Symptomatic Left Ventricular Dysfunction in Subjects 65 Years Old or Older (from the Cardiovascular Health Study)
Pandhi, J., Gottdiener, J. S., Bartz, T. M., Kop, W. J., & Mehra, M. R. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.01.051 · Cited by 23 · see citing works
Abstract 2386: Asymptomatic Left Ventricular Systolic Dysfunction as a Predictor of Incident Heart Failure and Mortality in the Elderly: The Cardiovascular Health Study
Pandhi, J., Kop, W. J., & Gottdiener, J. S. (2008) · Circulation · doi:10.1161/circ.118.suppl_18.s_715-a
Is Mild Asymptomatic Left Ventricular Systolic Dysfunction Always Predictive of Adverse Events in High-Risk Populations? Insights from the David-Berg Study
Gori, M., Redfield, M. M., Calabrese, A., Canova, P. A., Cioffi, G., Maria, R. D., Grosu, A., Fontana, A., Iacovoni, A., Ferrari, P., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1298 · Cited by 17 · see citing works

Authors: Wang, T. J., Evans, J. C., Benjamin, E. J., Levy, D., LeRoy, E. C., & Vasan, R. S.
Affiliations: Boston University (US)
ORCID: Wang, Thomas J.
Benjamin, Emelia J.
Levy, Daniel
Vasan, Ramachandran S.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-08-26
Volume: 108
Issue: 8
Pages: 977-982
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000085166.44904.79
OpenAlex: W2095689312
Semantic Scholar: c0b4cca1f7420447dfabc94c7398e07a3c8a6163
Cited by: 633
References: 24
Citations by year: 2026: 21 · 2025: 21 · 2024: 28 · 2023: 22 · 2022: 20 · 2021: 45 · 2020: 31 · 2019: 36 · 2018: 29 · 2017: 39 · 2016: 32 · 2015: 21 · 2014: 28 · 2013: 37 · 2012: 36
FWCI: 11.05
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k23hl074077-03, 5k24hl004334-08, n01hc25195-41-0-1, 5r01ns017950-40)
National Heart, Lung, and Blood Institute (K23 HL074077-01, K24-HL-04334-01A1, N01‐HC25195)
National Institute of Neurological Disorders and Stroke (5-R01-NS-17950)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords: natural history (disease), congestive heart failure, mortality risk, ejection fraction, Framingham Heart Study, community-based cohort, disease progression
MeSH terms: Adult, Aged, Aged, 80 and over, Echocardiography, Female, Follow-Up Studies, Heart Failure, Humans, Male, Massachusetts, Middle Aged, Risk Factors, Stroke Volume, Systole, Cohort Studies, Comorbidity, Incidence, Prevalence, Survival Rate, Proportional Hazards Models, Age of Onset, Age Distribution, Disease Progression, Ventricular Dysfunction, Left, Risk Assessment, Disease-Free Survival

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Natural history of asymptomatic left ventricular systolic dysfunction in the community

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