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Inverse Relationship between Serum Osteocalcin Levels and Visceral Fat Area in Chinese Men
Abstract
OBJECTIVE: The relationship between serum osteocalcin levels and body fat distribution remains unclear. This study aimed to investigate the association between serum osteocalcin levels and visceral fat area (VFA) in Chinese men. DESIGN: Total serum osteocalcin levels were measured in 1768 Chinese men (22-75 yr old) by electrochemiluminescence immunoassay. VFA was quantified via magnetic resonance imaging. Correlation analyses were carried out for serum osteocalcin levels and clinical parameters. Subgroup analysis was carried out to confirm the correlations using subjects with normal glucose tolerance and normal body mass index chosen from the entire study population. RESULTS: Increased serum osteocalcin levels were accompanied by a decreasing trend in all anthropometric indices of obesity, systolic blood pressure, blood glucose, insulin resistance index, triglycerides, free fatty acid, and C-reactive protein levels (all P < 0.05). The 50-75th (osteocalcin level: 16.18-19.88 ng/ml) and 75th (≥19.89 ng/ml) percentile groups had lower VFA than the 25th (≤13.11 ng/ml) and 25-50th (13.12-16.17 ng/ml) percentile groups (96.0 ± 44.4 and 89.8 ± 44.4 cm(2) vs. 108.1 ± 41.9 and 102.9 ± 44.9 cm(2), P < 0.05). A decreasing trend in serum osteocalcin levels was found to accompany the increase in VFA. Multiple stepwise regression analysis showed that VFA, as an independent factor, was inversely associated with serum osteocalcin levels both in the entire study population and subgroup population (all P < 0.01). CONCLUSIONS: Serum osteocalcin levels were inversely correlated with VFA in Chinese men.
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“Importantly, OCN was independently associated with visceral fat area [206], implying an involvement in the regulation of VAT.”
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Metadata
- Authors
- Bao, Y., Ma, X., Yang, R., Wang, F., Hao, Y., Dou, J., He, H., & Jia, W.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Jia, Weiping
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-01
- Volume
- 98
- Issue
- 1
- Pages
- 345-351
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2034200476
- Cited by
- 116
- References
- 29
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 3 · 2022: 11 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 13 · 2017: 8 · 2016: 15 · 2015: 14 · 2014: 11 · 2013: 7
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (973 Program, 11JC1409600, 81170788, 2012CB524906, 81100563)
- Shanghai Jiao Tong University
- National Key Research and Development Program of China (11JC1409600, 2012BAI02B03)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- osteocalcin, visceral fat area, body fat distribution, obesity, insulin resistance, Chinese men, metabolic risk factors
- MeSH terms
- Adult, Aged, Humans, Hyperlipidemias, Insulin Resistance, Male, Middle Aged, Osteocalcin, Case-Control Studies, Asian People, Intra-Abdominal Fat, Body Fat Distribution, Young Adult, Obesity, Abdominal
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