Regulation of energy metabolism by the skeleton: osteocalcin and beyond

Ferron, Mathieu; Lacombe, Julie

doi:10.1016/j.abb.2014.05.022

Cited by 211Bone Metabolism and DiseasesAdipokines, Inflammation, and Metabolic DiseasesBone health and osteoporosis research

Regulation of energy metabolism by the skeleton: osteocalcin and beyond

Ferron, Mathieu, Lacombe, Julie·2014·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2014.05.022

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Abstract

The skeleton has recently emerged as an endocrine organ implicated in the regulation of glucose and energy metabolism. This function of bone is mediated, at least in part, by osteocalcin, an osteoblast-derived protein acting as a hormone stimulating insulin sensitivity, insulin secretion and energy expenditure. Osteocalcin secretion and bioactivity is in turn regulated by several hormonal cues including insulin, leptin, the sympathetic nervous system and glucocorticoids. Recent findings support the notion that osteocalcin functions and regulations are conserved between mice and humans. Moreover, studies in mice suggest that osteocalcin could represent a viable therapeutic approach for the treatment of obesity and insulin resistance. In this review, we summarize the current knowledge on osteocalcin functions, its various modes of action and the mechanisms implicated in the control of this hormone.

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Among patients with endogenous Cushing syndrome, 20% to 45% have diabetes and 10% to 30% have defective glucose tolerance, so overall prevalence of glucose metabolism impairment can approach 70%.
“From % to % of patients with endogenous CS have DM, and % to % have defective glucose tolerance, so the overall prevalence of glucose metabolism impairments can come close to %, as shown in Table  (, , -).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [143]

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Relation of Serum Osteocalcin Level to Risk of Coronary Heart Disease in Chinese Adults
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Serum Osteocalcin Is Not Associated with Glucose but Is Inversely Associated with Leptin across Generations of Nondiabetic Women
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Osteoblast-specific expression of Fra-2/AP-1 controls Adiponectin/Osteocalcin expression and affects metabolism
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Cross-Sectional Evidence of a Signaling Pathway from Bone Homeostasis to Glucose Metabolism
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Circulating Osteocalcin Level Is Not Associated With Incident Type 2 Diabetes in Middle-Aged Male Subjects
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Knock‐in of nuclear localised β‐galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar
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Association between serum osteocalcin, adiposity and metabolic risk in obese children and adolescents
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GSK-3β Function in Bone Regulates Skeletal Development, Whole-Body Metabolism, and Male Life Span
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Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus
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Vitamin D, osteocalcin, and risk for adiposity as comorbidities in middle school children
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Serum concentrations of carboxylated osteocalcin are increased and associated with several components of the polycystic ovarian syndrome
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Serum osteocalcin levels are inversely associated with abdominal aortic calcification in men with type 2 diabetes mellitus
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Osteoid osteoma is an osteocalcinoma affecting glucose metabolism
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Relationship between serum osteocalcin levels and non‐alcoholic fatty liver disease in Chinese men
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T-Cell Protein Tyrosine Phosphatase Regulates Bone Resorption and Whole-Body Insulin Sensitivity through Its Expression in Osteoblasts
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X-ray Crystal Structure of Bovine 3 Glu-Osteocalcin
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Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male
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Changes in Serum Osteocalcin are Not Associated with Changes in Glucose or Insulin for Osteoporotic Patients Treated with Bisphosphonate
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Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss
Fernández‐Real, J. M., Ortega, F. J., Gómez‐Ambrosi, J., Salvador, J., Frühbeck, G., & Ricart, W. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1174-9 · Cited by 30 · see citing works
Osteocalcin and vitamin D status are inversely associated with homeostatic model assessment of insulin resistance in Canadian Aboriginal and white women: the First Nations Bone Health Study
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Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice
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Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women
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Analysis of Osteocalcin as a Candidate Gene for Type 2 Diabetes (T2D) and Intermediate Traits in Caucasians and African Americans
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Relationship between Serum Osteocalcin Levels and Non-Alcoholic Fatty Liver Disease in Adult Males, South China
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Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells
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A Cut-Point Value of Uncarboxylated to Carboxylated Index is Associated with Glycemic Status Markers in Type 2 Diabetes
Villafán-Bernal, J. R., Llamas-Covarrubias, M. A., Muñóz-Valle, J. F., Rivera-León, E. A., González-Hita, M. E., Bastidas‐Ramírez, B. E., Gurrola‐Díaz, C. M., Armendáriz‐Borunda, J., & Sánchez‐Enríquez, S. (2014) · Journal of Investigative Medicine · doi:10.2310/jim.0000000000000015 · Cited by 23 · see citing works
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Sarkar, P. D., & Choudhury, A. B. (2012) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2012.715651 · Cited by 23 · see citing works
CTX (Crosslaps) Rather than Osteopontin Is Associated with Disturbed Glucose Metabolism in Gestational Diabetes
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Serum levels of osteocalcin in relation to glucose metabolism and carotid atherosclerosis in Chinese middle-aged and elderly male adults: The Shanghai Changfeng Study
Ma, H., Lin, H., Hu, Y., Li, X., He, W., Jin, X., Gao, J., Zhao, N., & Gao, X. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2014.01.017 · Cited by 20 · see citing works
Interactions between adipose, bone, and muscle tissue markers during acute negative energy balance in male rowers.
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Post-menopausal women with rheumatoid arthritis who are treated with raloxifene or alendronate or glucocorticoids have lower serum undercarboxylated osteocalcin levels.
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Serum osteocalcin levels are useful as a predictor of cardiovascular events in maintenance hemodialysis patients
Yamashita, T., Okano, K., Tsuruta, Y., Akiba, T., & Nitta, K. (2012) · International Urology and Nephrology · doi:10.1007/s11255-012-0156-6 · Cited by 19 · see citing works
Osteocalcin is inversely associated with glucose levels in middle‐aged Tibetan men with different degrees of glucose tolerance
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Role of adiponectin in mediating the association of osteocalcin with insulin resistance and type 2 diabetes: a cross sectional study in pre- and post-menopausal women
Choudhury, A. B., Sarkar, P. D., Sakalley, D. K., & Petkar, S. (2014) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.877488 · Cited by 17 · see citing works
Association between serum osteocalcin and insulin resistance in postmenopausal, but not premenopausal, women in Korea
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A cross‐sectional study of osteocalcin and body fat measures among obese adolescents
Lenders, C. M., Lee, P., Feldman, H. A., Wilson, D. M., Abrams, S. H., Gitelman, S. E., Klish, W. J., Wertz, M. S., Taylor, G. A., Alongi, R. T., et al. (2013) · Obesity · doi:10.1002/oby.20131 · Cited by 16 · see citing works
Relationships between serum osteocalcin, leptin and the effect of weight loss by pharmacological treatment in healthy, nonsmoking Korean obese adults
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Osteocalcin Levels on Oral Glucose Load in Women being Investigated for Polycystic Ovary Syndrome
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Serum undercarboxylated osteocalcin level increases with 48 weeks of teriparatide treatment in pre-treated elderly rheumatoid arthritis patients who use anti-resorptive drugs
Mokuda, S., Sawada, N., Matoba, K., Yamada, A., Onishi, M., Okuda, Y., Jouyama, K., Murata, Y., & Takasugi, K. (2012) · Journal of Endocrinological Investigation · doi:10.1007/bf03347100 · Cited by 15 · see citing works
The serum undercarboxylated osteocalcin level and the diet of a Japanese population: results from the Kyushu and Okinawa Population Study (KOPS)
Furusyo, N., Ihara, T., Hayashi, T., Ikezaki, H., Toyoda, K., Ogawa, E., Okada, K., Kainuma, M., Murata, M., & Hayashi, J. (2012) · Endocrine · doi:10.1007/s12020-012-9803-z · Cited by 15 · see citing works
Serum under-carboxylated osteocalcin levels in women with polycystic ovary syndrome: weight-dependent relationships with endocrine and metabolic traits
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Effects of correction of vitamin D insufficiency on serum osteocalcin and glucose metabolism in obese children
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Interplay Between Serum Osteocalcin and Insulin Sensitivity in Primary Hyperparathyroidism
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Effect of treatment with alendronate in osteogenesis imperfecta type I: a case report
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Osteocalcin is independently associated with body mass index in adolescent girls
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Osteotesticular Protein Tyrosine Phosphatase Expression in Rodent Testis
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Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
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The systemic nature of CKD
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The role of leptin in regulating bone metabolism
Upadhyay, J., Farr, O. M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.021 · Cited by 270 · see citing works
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Mizokami, A., Kawakubo‐Yasukochi, T., & Hirata, M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.02.001 · Cited by 209 · see citing works
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Yang, D., Yang, Y., Li, Y., & Han, R. (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000500110 · Cited by 157 · see citing works
Glucocorticoid-Induced Fatty Liver Disease
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Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management
Scaroni, C., Zilio, M., Foti, M., & Boscaro, M. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1105 · Cited by 140 · see citing works
Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility
Eller-Vainicher, C., Cairoli, E., Grassi, G., Grassi, F., Catalano, A., Merlotti, D., Falchetti, A., Gaudio, A., Chiodini, I., & Gennari, L. (2020) · Journal of Diabetes Research · doi:10.1155/2020/7608964 · Cited by 133 · see citing works
Structural and functional insights into enzymes of the vitamin K cycle
Tie, J., & Stafford, D. W. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13217 · Cited by 134 · see citing works
Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect
Ivanova, D., Zhelev, Z., Getsov, P. G., Nikolova, B., Aoki, I., Higashi, T., & Bakalova, R. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.013 · Cited by 129 · see citing works
Endocrine role of bone: recent and emerging perspectives beyond osteocalcin
Oldknow, K. J., MacRae, V. E., & Farquharson, C. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0584 · Cited by 109 · see citing works
Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones
Wang, J. S., Mazur, C. M., & Wein, M. N. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.584147 · Cited by 110 · see citing works
ER stress and inflammation crosstalk in obesity
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Bone Cell Bioenergetics and Skeletal Energy Homeostasis
Riddle, R. C., & Clemens, T. L. (2017) · Physiological Reviews · doi:10.1152/physrev.00022.2016 · Cited by 100 · see citing works
Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots
Fulzele, K. S., Lai, F., Dedic, C., Saini, V., Uda, Y., Shi, C., Tuck, P., Aronson, J., Liu, X., Spatz, J., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3001 · Cited by 100 · see citing works
Osteocalcin Regulates Arterial Calcification Via Altered Wnt Signaling and Glucose Metabolism
Rashdan, N. A., Sim, A. M., Cui, L., Phadwal, K., Roberts, F. L., Carter, R., Ozdemir, D. D., Hohenstein, P., Hung, J., Kaczynski, J., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3888 · Cited by 92 · see citing works
Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK
Du, J., Zhang, M., Lu, J., Zhang, X., Xiong, Q., Xu, Y., Bao, Y., & Jia, W. (2016) · Endocrine · doi:10.1007/s12020-016-0926-5 · Cited by 84 · see citing works
Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation
Audira, G., Sarasamma, S., Chen, J., Juniardi, S., Sampurna, B. P., Liang, S., Lai, Y., Lin, G.-M., Hsieh, M., & Hsiao, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124038 · Cited by 81 · see citing works
Bone mineral density in people living with HIV: a narrative review of the literature
Kruger, M., & Nell, T. A. (2017) · AIDS Research and Therapy · doi:10.1186/s12981-017-0162-y · Cited by 80 · see citing works
Relative Energy Deficiency in Sport (REDs): Endocrine Manifestations, Pathophysiology and Treatments
Angelidi, A. M., Stefanakis, K., Chou, S. H.-H., Valenzuela‐Vallejo, L., Δίπλα, Κ., Boutari, C., Ntoskas, K. T., Tokmakidis, P., Kokkinos, A. D., Goulis, D. G., et al. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae011 · Cited by 95 · see citing works
What is “Hyper” in the ALS Hypermetabolism?
Ferri, A., & Coccurello, R. (2017) · Mediators of Inflammation · doi:10.1155/2017/7821672 · Cited by 77 · see citing works
Osteopetrosis and Its Relevance for the Discovery of New Functions Associated with the Skeleton
Coudert, A. E., de Vernejoul, M. C., Muraca, M., & Fattore, A. D. (2015) · International Journal of Endocrinology · doi:10.1155/2015/372156 · Cited by 76 · see citing works
GGCX and VKORC1 inhibit osteocalcin endocrine functions
Ferron, M., Lacombe, J., Germain, A., Oury, F., & Karsenty, G. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201409111 · Cited by 71 · see citing works
Effects of exercise training on serum preptin, undercarboxylated osteocalcin and high molecular weight adiponectin in adults with metabolic syndrome
Rahimi, G. R. M., Bijeh, N., & Rashidlamir, A. (2019) · Experimental Physiology · doi:10.1113/ep088036 · Cited by 69 · see citing works
The Bone—Vasculature Axis: Calcium Supplementation and the Role of Vitamin K
Wasilewski, G. B., Vervloet, M. G., & Schurgers, L. J. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00006 · Cited by 59 · see citing works
Phloridzin, an Apple Polyphenol, Exerted Unfavorable Effects on Bone and Muscle in an Experimental Model of Type 2 Diabetes in Rats
Londzin, P., Siudak, S., Cegieła, U., Pytlik, M., Janas, A., Waligóra, A., & Folwarczna, J. (2018) · Nutrients · doi:10.3390/nu10111701 · Cited by 57 · see citing works
Leptin physiology and pathophysiology in energy homeostasis, immune function, neuroendocrine regulation and bone health
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Bone disease in cystic fibrosis: new pathogenic insights opening novel therapies
Jacquot, J. P., Delion, M. F., Gangloff, S. C., Braux, J., & Velard, F. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3343-3 · Cited by 56 · see citing works
Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System
Folwarczna, J., Janas, A., Pytlik, M., Cegieła, U., Śliwiński, L., Krivošíková, Z., Stefikova, K., & Gajdoš, M. (2016) · Nutrients · doi:10.3390/nu8030133 · Cited by 55 · see citing works
Glucose and lipid metabolism abnormalities in C ushing's syndrome
Salehidoost, R., & Korbonits, M. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13143 · Cited by 56 · see citing works
Endocrine roles of vitamin K-dependent- osteocalcin in the relation between bone metabolism and metabolic disorders
Al-Suhaimi, E. A., & Aljafary, M. A. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09517-9 · Cited by 56 · see citing works
Osteocalcin: Beyond Bones
Nowicki, J. K., & Jakubowska‐Pietkiewicz, E. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1895 · Cited by 53 · see citing works
Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk
Magarò, M. S., Bertacchini, J., Florio, F., Zavatti, M., Potì, F., Cavani, F., Amore, E., Santis, I. D., Bevilacqua, A., Bonetti, L. R., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9010071 · Cited by 50 · see citing works
Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK‐ERK signalling pathway in vivo and in vitro
Han, Y., Ma, B., Guo, S., Yang, M., Li, L., Wang, S., & Tan, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13398 · Cited by 51 · see citing works
Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women
Xu, Y., Ma, X., Pan, X., He, X., Xiao, Y., & Bao, Y. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0786-9 · Cited by 46 · see citing works
Body Composition in Children and Adolescents with Osteogenesis Imperfecta
Palomo, T., Glorieux, F. H., Schöenau, E., & Rauch, F. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.10.058 · Cited by 43 · see citing works
Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes
Raźny, U., Fedak, D., Kieć‐Wilk, B., Góralska, J., Gruca, A., Zdzienicka, A., Kieć-Klimczak, M., Solnica, B., Hubalewska–Dydejczyk, A., & Malczewska-Malec, M. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2862 · Cited by 42 · see citing works
Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell function
Lacombe, J., Rifai, O. A., Loter, L., Moran, T. M., Turcotte, A., Grenier–Larouche, T., Tchernof, A., Biertho, L. D., Carpentier, A. C., Prud’homme, D., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00321.2019 · Cited by 42 · see citing works
Evidence of a link between resting energy expenditure and bone remodelling, glucose homeostasis and adipokine variations in adolescent girls with anorexia nervosa
Maı̈moun, L., Guillaume, S., Lefebvre, P., Philibert, P., Bertet, H., Picot, M., Gaspari, L., Paris, F., Sénèque, M., Dupuys, A.-M., et al. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3223-x · Cited by 40 · see citing works
Relationships between Bone Turnover and Energy Metabolism
Fernandes, T., Gonçalves, L. M. L., & Brito, J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/9021314 · Cited by 41 · see citing works
Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases
Schroeder, H. T., Muller, C. H. D. L., Heck, T. G., Krause, M. D. S., & de Bittencourt, P. I. H. (2024) · Cell Stress and Chaperones · doi:10.1016/j.cstres.2024.01.002 · Cited by 42 · see citing works
Metabolic Health and Disease: A Role of Osteokines?
Shimonty, A., Bonewald, L. F., & Huot, J. R. (2023) · Calcified Tissue International · doi:10.1007/s00223-023-01093-0 · Cited by 38 · see citing works
Simulated space radiation sensitizes bone but not muscle to the catabolic effects of mechanical unloading
Krause, A. R., Speacht, T. L., Zhang, Y., Lang, C. H., & Donahue, H. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182403 · Cited by 38 · see citing works
The roles of osteocalcin in lipid metabolism in adipose tissue and liver
Otani, T., Mizokami, A., Kawakubo‐Yasukochi, T., Takeuchi, H., Inai, T., & Hirata, M. (2020) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100752 · Cited by 38 · see citing works
Insulin resistance, bone health, and fracture risk
Armutçu, F., & McCloskey, E. V. (2024) · Osteoporosis International · doi:10.1007/s00198-024-07227-w · Cited by 34 · see citing works
Association between osteocalcin gamma-carboxylation and insulin resistance in overweight and obese postmenopausal women
Bonneau, J., Ferland, G., Karelis, A. D., Doucet, É., Faraj, M., RABASA-LHORET, R. P. R., & Ferron, M. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.01.023 · Cited by 32 · see citing works
Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial
Shea, M. K., Dawson-Hughes, B., Gundberg, C. M., & Booth, S. L. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2989 · Cited by 31 · see citing works
Energy Metabolism and Ketogenic Diets: What about the Skeletal Health? A Narrative Review and a Prospective Vision for Planning Clinical Trials on this Issue
Merlotti, D., Cosso, R., Eller-Vainicher, C., Vescini, F., Chiodini, I., Gennari, L., & Falchetti, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010435 · Cited by 31 · see citing works
Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet
Yasutake, Y., Mizokami, A., Kawakubo‐Yasukochi, T., Chishaki, S., Takahashi, I., Takeuchi, H., & Hirata, M. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00334.2015 · Cited by 32 · see citing works
The rs2274911 polymorphism in GPRC 6A gene is associated with insulin resistance in normal weight and obese subjects
Nisio, A. D., Rocca, M. S., Fadini, G. P., Toni, L. D., Marcuzzo, G., Marescotti, M. C., Sanna, M., Plebani, M., Vettor, R., Avogaro, A., et al. (2016) · Clinical Endocrinology · doi:10.1111/cen.13248 · Cited by 30 · see citing works
Adiposity Metabolic Consequences for Adolescent Bone Health
Lopes, K. G., Rodrigues, E. L., Lopes, M. R. D. S., do Nascimento, V. A., Pott, A., Guimarães, R. D. C. A., Pegolo, G. E., & Freitas, K. D. C. (2022) · Nutrients · doi:10.3390/nu14163260 · Cited by 30 · see citing works
Endurance exercise and growth hormone improve bone formation in young and growth-retarded chronic kidney disease rats
Troib, A., Guterman, M., Rabkin, R., Landau, D., & Segev, Y. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv373 · Cited by 29 · see citing works
Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running
Hinton, P. S., Shankar, K., Eaton, L. M., & Rector, R. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.04.004 · Cited by 28 · see citing works
Rethinking Fragility Fractures in Type 2 Diabetes: The Link between Hyperinsulinaemia and Osteofragilitas
Cooper, I. D., Brookler, K. H., & Crofts, C. A. P. (2021) · Biomedicines · doi:10.3390/biomedicines9091165 · Cited by 25 · see citing works
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Authors: Ferron, M., & Lacombe, J.
Affiliations: Montreal Clinical Research Institute (CA)
Corresponding author: Ferron, Mathieu
ORCID: Ferron, Mathieu
Lacombe, Julie
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2014-11
Volume: 561
Pages: 137-146
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2014.05.022
OpenAlex: W2048096271
Cited by: 211
References: 179
Citations by year: 2026: 5 · 2025: 12 · 2024: 15 · 2023: 21 · 2022: 17 · 2021: 16 · 2020: 21 · 2019: 16 · 2018: 20 · 2017: 24 · 2016: 19 · 2015: 19 · 2014: 5 · 2013: 1
FWCI: 2.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: osteocalcin, bone endocrine function, energy metabolism, glucose metabolism, insulin sensitivity, insulin secretion, energy expenditure, leptin, sympathetic nervous system, glucocorticoids, obesity, insulin resistance, osteoblasts, therapeutic target
MeSH terms: Animals, Bone and Bones, Energy Metabolism, Glucose, Homeostasis, Humans, Insulin, Insulin Resistance, Osteocalcin, Mice

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Regulation of energy metabolism by the skeleton: osteocalcin and beyond

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