The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Dehydroepiandrosterone Supplementation in Elderly Men: A Meta-Analysis Study of Placebo-Controlled Trials
Abstract
Context Age-related dehydroepiandrosterone (DHEA) deficiency has been associated with a broad range of biological abnormalities in males. Object Our objective was to meta-analyze all double-blind, placebo-controlled randomized trials (RCTs) investigating the effect of oral DHEA (DHEA supplementation) in comparison with placebo on sexual and metabolic outcomes in elderly men. Data source An extensive Medline Embase and Cochrane search was performed including the following words: DHEA, RCTs, and males. Study selection Only double-blind placebo-controlled trials performed in elderly men were included. Data extraction Data extraction was performed independently by 2 of the authors (A.S. and V.G.), and conflicts were resolved by the third investigator (G.C.). The quality of RCTs was assessed using the Cochrane criteria. Results Of 220 retrieved articles, 25 were included in the study. The available RCTs enrolled 1353 elderly men, with a mean follow-up of 36 weeks. DHEA supplementation was associated with a reduction of fat mass (standardized mean difference of -0.35 [-0.65 to -0.05]; P = .02). However, the association with fat mass disappeared in a multivariate regression model after adjusting for DHEA-related metabolite increases such as total testosterone and estradiol. In contrast to what was observed for fat mass, no effect of DHEA supplementation in comparison with placebo was observed for various clinical parameters including lipid and glycemic metabolism, bone health, sexua…
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“A 2013 meta-analysis of 25 randomized controlled trials studying DHEA use in over 1,300 men found that DHEA supplementation was associated with small improvements in body fat composition, but no improvements were noted in total serum testosterone, glucose or lipid profiles, bone mineral density, or mental or physical quality of life outcomes (38).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [38]
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Cites
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
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A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease.
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DHEA in elderly women and DHEA or testosterone in elderly men.
Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054629 · Cited by 566
Klinefelter Syndrome—A Clinical Update
Groth, K. A., Skakkebaek, A. H., Høst, C., Gravholt, C. H., & Bojesen, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2382 · Cited by 513
Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study
Corona, G., Rastrelli, G., Monami, M., Guay, A., Buvat, J., Sforza, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0447 · Cited by 435
Self-citationMorales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00507.x · Cited by 418
Corona, G., Rastrelli, G., Monami, M., Saad, F., Luconi, M., Lucchese, M., Facchiano, E., Sforza, A., Forti, G., Mannucci, E., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-0955 · Cited by 414
Self-citationNESTLER, J. E., BARLASCINI, C. O., CLORE, J. N., & BLACKARD, W. G. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-57 · Cited by 414
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Items 101–104 of 104
Sarkar, K., Biswas, D., Sreenivas, B. Y., Naimisha, R., Bung, N., Madhuri, S. S., Medishetti, R., Roy, A., Giliyaru, V. B., Yadav, P. N., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109287
Hormonal Supplements for Health and Longevity
Kharwanlang, B., & Sharma, R. (2026) · Healthy ageing and longevity · doi:10.1007/978-3-032-11608-6_4
Ashour, L., Altiti, L., Khawaldeh, R., Abuqudaira, B., Wadi, R. H., Jaber, M., Najadat, B., Jaber, S., Awwad, R. I., Smadi, T. W., et al. (2026) · Nutrition and Health · doi:10.1177/02601060261483849
Metadata
- Authors
- Corona, G., Rastrelli, G., Giagulli, V. A., Sila, A., Sforza, A., Forti, G., Mannucci, E., & Maggi, M.
- Affiliations
- Ospedale Bellaria (IT)
- University of Florence (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Corresponding author
- Maggi, Mario
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-09
- Volume
- 98
- Issue
- 9
- Pages
- 3615-3626
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1975009246
- Cited by
- 105
- References
- 64
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 26 · 2022: 6 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 15 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 3
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- dehydroepiandrosterone, DHEA supplementation, older men, fat mass, body composition, testosterone, estradiol, sexual function, bone health, lipid metabolism, glucose metabolism, quality of life
- MeSH terms
- Aged, Body Composition, Bone and Bones, Dehydroepiandrosterone, Humans, Male, Controlled Clinical Trials as Topic, Dietary Supplements, Hormone Replacement Therapy
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